The ADVANCE (AI Discovery & Vigilance to Accelerate Innovation & Clinical Excellence) Center is housed in the Department of Biomedical Informatics at VUMC and serves as a collaborative hub for interdisciplinary research and practice, fostering partnerships between clinicians, researchers, data scientists, and industry leaders. By facilitating cross-disciplinary collaboration, the Center aims to address complex healthcare challenges and drive transformative innovations. Through data analytics, machine learning, predictive modeling, and generative AI, ADVANCE empowers healthcare professionals and scientists to make informed decisions, enhance patient outcomes, and accelerate biomedical discoveries.