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Marmor HN, Kammer MN, Deppen SA, Shipe M, Welty VF**, Patel K, Godfrey C, Billatos E, Herman JG, Wilson DO, Kussrow AK, Bornhop DJ, Maldonado F, Chen H*, Grogan EL. Improving lung cancer diagnosis with cancer, fungal, and imaging biomarkers. The Journal of thoracic and cardiovascular surgery. 2022 Dec 23.
Abstract
Indeterminate pulmonary nodules (IPNs) represent a significant diagnostic burden in health care. We aimed to compare a combination clinical prediction model (Mayo Clinic model), fungal (histoplasmosis serology), imaging (computed tomography [CT] radiomics), and cancer (high-sensitivity cytokeratin fraction 21; hsCYFRA 21-1) biomarker approach to a validated prediction model in diagnosing lung cancer.