Population pharmacokinetic analysis of dexmedetomidine in children using real-world data from electronic health records and remnant specimens.

James NT**, Breeyear JH, Caprioli R, Edwards T, Hachey B, Kannankeril PJ, Keaton JM, Marshall MD, Van Driest SL, Choi L*. Population pharmacokinetic analysis of dexmedetomidine in children using real-world data from electronic health records and remnant specimens. British journal of clinical pharmacology. 2022 Jun;88(88). 2885-2898. PMID: 34957589 [PubMed] PMCID: PMC9106818 NIHMSID: NIHMS1767210.

Abstract

Our objectives were to perform a population pharmacokinetic analysis of dexmedetomidine in children using remnant specimens and electronic health records (EHRs) and explore the impact of patient's characteristics and pharmacogenetics on dexmedetomidine clearance.