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Ma L, Shaver CM, Grove BS, Mitchell DB, Wickersham NE, Carnahan RH, Cooper TL, Brake BE, Ware LB, Bastarache JA. Kinetics of lung tissue factor expression and procoagulant activity in bleomycin induced acute lung injury. Clinical and translational medicine. 2015 Dec;4(4). 63 p.
Abstract
Activation of coagulation by expression of tissue factor (TF) in the airspace is a hallmark of acute lung injury (ALI) but the timing of TF activation in relationship to increases in lung permeability and inflammation are unknown.