2022
-
Gilchuk P, Schmitz J. Thomsen I, Yoder S, Brady E, Chappell J, Stevens L, Denison M, Sutton R, Chen R, VanBlargan L, Suryadevara N, Zost S, Pulley J, Diamond M, Rhoads J, Bernard G, Self W, Rice T, Wheeler A, Crowe J, Carnahan R. Standardized two-step testing of antibody activity in COVID-19 convalescent plasma IScience. Cell Press; 2022 Jan 21;25(25).
2020
-
Anderson EJ, Rouphael NG, Widge AT, Jackson LA, Roberts PC, Makhene M, Chappell JD, Denison MR, Stevens LJ, Pruijssers AJ, McDermott AB, Flach B, Lin BC, Doria-Rose NA, O'Dell S, Schmidt SD, Corbett KS, Swanson PA, Padilla M, Neuzil KM, Bennett H, Leav B, Makowski M, Albert J, Cross K, Edara VV, Floyd K, Suthar MS, Martinez DR, Baric R, Buchanan W, Luke CJ, Phadke VK, Rostad CA, Ledgerwood JE, Graham BS, Beigel JH. Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults. The New England journal of medicine. 2020 Dec 17;383(383). 2427-2438.
-
Widge AT, Rouphael NG, Jackson LA, Anderson EJ, Roberts PC, Makhene M, Chappell JD, Denison MR, Stevens LJ, Pruijssers AJ, McDermott AB, Flach B, Lin BC, Doria-Rose NA, O'Dell S, Schmidt SD, Neuzil KM, Bennett H, Leav B, Makowski M, Albert J, Cross K, Edara VV, Floyd K, Suthar MS, Buchanan W, Luke CJ, Ledgerwood JE, Mascola JR, Graham BS, Beigel JH. Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination. The New England journal of medicine. 2020 Dec 3.
-
Corbett KS, Edwards DK, Leist SR, Abiona OM, Boyoglu-Barnum S, Gillespie RA, Himansu S, Schäfer A, Ziwawo CT, DiPiazza AT, Dinnon KH, Elbashir SM, Shaw CA, Woods A, Fritch EJ, Martinez DR, Bock KW, Minai M, Nagata BM, Hutchinson GB, Wu K, Henry C, Bahl K, Garcia-Dominguez D, Ma L, Renzi I, Kong WP, Schmidt SD, Wang L, Zhang Y, Phung E, Chang LA, Loomis RJ, Altaras NE, Narayanan E, Metkar M, Presnyak V, Liu C, Louder MK, Shi W, Leung K, Yang ES, West A, Gully KL, Stevens LJ, Wang N, Wrapp D, Doria-Rose NA, Stewart-Jones G, Bennett H, Alvarado GS, Nason MC, Ruckwardt TJ, McLellan JS, Denison MR, Chappell JD, Moore IN, Morabito KM, Mascola JR, Baric RS, Carfi A, Graham BS. SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness. Nature. 2020 Dec;586(586). 567-571. NIHMSID: NIHMS1616529.
-
Pruijssers A. George A, Schäfer A, Leist S, Gralinksi L, Dinnon K, Yount B, Agostini M, Stevens L, Chappell J, Lu X, Hughes T, Gully K, Martinez D, Brown A, Graham R, Perry J, Du Pont V, Pitts J, Ma B, Babusis D, Murakami E, Feng J, Bilello J, Porter D, Cihlar T, Baric R, Denison M, Sheahan T. Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice Cell Reports. Cell; 2020 Jul 21;32(32).
-
Jackson LA, Anderson EJ, Rouphael NG, Roberts PC, Makhene M, Coler RN, McCullough MP, Chappell JD, Denison MR, Stevens LJ, Pruijssers AJ, McDermott A, Flach B, Doria-Rose NA, Corbett KS, Morabito KM, O'Dell S, Schmidt SD, Swanson PA, Padilla M, Mascola JR, Neuzil KM, Bennett H, Sun W, Peters E, Makowski M, Albert J, Cross K, Buchanan W, Pikaart-Tautges R, Ledgerwood JE, Graham BS, Beigel JH. An mRNA Vaccine against SARS-CoV-2 - Preliminary Report. The New England journal of medicine. 2020 Jul 14.
-
Pruijssers AJ, George AS, Schäfer A, Leist SR, Gralinksi LE, Dinnon KH, Yount BL, Agostini ML, Stevens LJ, Chappell JD, Lu X, Hughes TM, Gully K, Martinez DR, Brown AJ, Graham RL, Perry JK, Du Pont V, Pitts J, Ma B, Babusis D, Murakami E, Feng JY, Bilello JP, Porter DP, Cihlar T, Baric RS, Denison MR, Sheahan TP. Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice. Cell reports. 2020 Jul 7. 107940 p.
-
Chiotos K, Hayes M, Kimberlin DW, Jones SB, James SH, Pinninti SG, Yarbrough A, Abzug MJ, MacBrayne CE, Soma VL, Dulek DE, Vora SB, Waghmare A, Wolf J, Olivero R, Grapentine S, Wattier RL, Bio L, Cross SJ, Dillman NO, Downes KJ, Timberlake K, Young J, Orscheln RC, Tamma PD, Schwenk HT, Zachariah P, Aldrich M, Goldman DL, Groves HE, Lamb GS, Tribble AC, Hersh AL, Thorell EA, Denison MR, Ratner AJ, Newland JG, Nakamura MM. Multicenter initial guidance on use of antivirals for children with COVID-19/SARS-CoV-2. Journal of the Pediatric Infectious Diseases Society. 2020 Apr 22.
-
Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, Leist SR, Schäfer A, Dinnon KH, Stevens LJ, Chappell JD, Lu X, Hughes TM, George AS, Hill CS, Montgomery SA, Brown AJ, Bluemling GR, Natchus MG, Saindane M, Kolykhalov AA, Painter G, Harcourt J, Tamin A, Thornburg NJ, Swanstrom R, Denison MR, Baric RS. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Science translational medicine. 2020 Apr 6.
-
Sheahan TP, Sims AC, Leist SR, Schäfer A, Won J, Brown AJ, Montgomery SA, Hogg A, Babusis D, Clarke MO, Spahn JE, Bauer L, Sellers S, Porter D, Feng JY, Cihlar T, Jordan R, Denison MR, Baric RS. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nature communications. 2020 Jan 10;11(11). 222 p.
2019
-
Agostini ML, Pruijssers AJ, Chappell JD, Gribble J, Lu X, Andres EL, Bluemling GR, Lockwood MA, Sheahan TP, Sims AC, Natchus MG, Saindane M, Kolykhalov AA, Painter GR, Baric RS, Denison MR. Small molecule antiviral β-D--hydroxycytidine inhibits a proofreading-intact coronavirus with a high genetic barrier to resistance. Journal of virology. 2019 Oct 2.
-
Wang N, Rosen O, Wang L, Turner HL, Stevens LJ, Corbett KS, Bowman CA, Pallesen J, Shi W, Zhang Y, Leung K, Kirchdoerfer RN, Becker MM, Denison MR, Chappell JD, Ward AB, Graham BS, McLellan JS. Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD. Cell reports. 2019 Sep 24;28(28). 3395-3405.e6.
-
Graepel KW, Agostini ML, Lu X, Sexton NR, Denison MR. Fitness barriers limit reversion of a proofreading-deficient coronavirus. Journal of virology. 2019 Jul 24.
-
Brown AJ, Won JJ, Graham RL, Dinnon KH, Sims AC, Feng JY, Cihlar T, Denison MR, Baric RS, Sheahan TP. Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase. Antiviral research. 2019 Jun 21;169(169). 104541 p.
-
Pruijssers AJ, Denison MR. Nucleoside analogues for the treatment of coronavirus infections. Current opinion in virology. 2019 Apr;35(35). 57-62.
2018
-
Case JB, Li Y, Elliott R, Lu X, Graepel KW, Sexton NR, Smith EC, Weiss SR, Denison MR. Murine Hepatitis Virus nsp14 Exoribonuclease Activity Is Required for Resistance to Innate Immunity. Journal of virology. 2018 Dec 1;92(92).
-
Athmer J, Fehr AR, Grunewald ME, Qu W, Wheeler DL, Graepel KW, Channappanavar R, Sekine A, Aldabeeb DS, Gale M, Denison MR, Perlman S. Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses. MBio. 2018 May 1;9(9).
-
Wang L, Shi W, Chappell JD, Joyce MG, Zhang Y, Kanekiyo M, Becker MM, Van Doremalen N, Fischer R, Wang N, Corbett KS, Choe M, Mason RD, Van Galen JG, Zhou T, Saunders KO, Tatti KM, Haynes LM, Kwong PD, Modjarrad K, Kong WP, McLellan JS, Denison MR, Munster VJ, Mascola JR, Graham BS. Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on MERS-CoV Spike to avoid neutralization escape. Journal of virology. 2018 Mar 7.
-
Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, Baric RS, Denison MR. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9(9).
2017
-
Athmer J, Fehr AR, Grunewald M, Smith EC, Denison MR, Perlman S. In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins. MBio. 2017 Dec 31;8(8).
-
Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS. Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen. Proceedings of the National Academy of Sciences of the United States of America. 2017 Dec 29;114(114). E7348-E7357.
-
Arabi YM, Balkhy HH, Hayden FG, Bouchama A, Luke T, Baillie JK, Al-Omari A, Hajeer AH, Senga M, Denison MR, Nguyen-Van-Tam JS, Shindo N, Bermingham A, Chappell JD, Van Kerkhove MD, Fowler RA. Middle East Respiratory Syndrome. The New England journal of medicine. 2017 Dec 9;376(376). 584-594. NIHMSID: EMS71785.
-
Graepel KW, Lu X, Case JB, Sexton NR, Smith EC, Denison MR. Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating Mutations. MBio. 2017 Nov 7;8(8).
-
Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, Spahn JE, Palmiotti CA, Siegel D, Ray AS, Cihlar T, Jordan R, Denison MR, Baric RS. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Science translational medicine. 2017 Jun 28;9(9). NIHMSID: NIHMS895143.
2016
-
Mounce BC, Cesaro T, Moratorio G, Hooikaas PJ, Yakovleva A, Werneke SW, Smith EC, Poirier EZ, Simon-Loriere E, Prot M, Tamietti C, Vitry S, Volle R, Khou C, Frenkiel MP, Sakuntabhai A, Delpeyroux F, Pardigon N, Flamand M, Barba-Spaeth G, Lafon M, Denison MR, Albert ML, Vignuzzi M. Inhibition of polyamine biosynthesis is a broad-spectrum strategy against RNA viruses. Journal of virology. 2016 Aug 17.
-
Sexton NR, Smith EC, Blanc H, Vignuzzi M, Peersen OB, Denison MR. Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens. Journal of virology. 2016 Aug 15;90(90). 7415-28.
-
Case JB, Ashbrook AW, Dermody TS, Denison MR. Mutagenesis of S-Adenosyl-l-Methionine-Binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity. Journal of virology. 2016 Aug 15;90(90). 7248-56.
2015
-
Tomar S, Johnston ML, St John SE, Osswald HL, Nyalapatla PR, Paul LN, Ghosh AK, Denison MR, Mesecar AD. Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS. The Journal of biological chemistry. 2015 Aug 7;290(290). 19403-22.
-
Smith EC, Case JB, Blanc H, Isakov O, Shomron N, Vignuzzi M, Denison MR. Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelity. Journal of virology. 2015 Jun;89(89). 6418-26.
-
Beachboard DC, Anderson-Daniels JM, Denison MR. Mutations across murine hepatitis virus nsp4 alter virus fitness and membrane modifications. Journal of virology. 2015 Feb;89(89). 2080-9.
2014
-
Smith EC, Sexton NR, Denison MR. Thinking Outside the Triangle: Replication Fidelity of the Largest RNA Viruses. Annual review of virology. 2014 Nov;1(1). 111-32.
-
Khuri-Bulos N, Payne DC, Lu X, Erdman D, Wang L, Faouri S, Shehabi A, Johnson M, Becker MM, Denison MR, Williams JV, Halasa NB. Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Amman, Jordan, March 2010 to September 2012. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2014 Jul;20(20). 678-82.
-
Freeman MC, Graham RL, Lu X, Peek CT, Denison MR. Coronavirus replicase-reporter fusions provide quantitative analysis of replication and replication complex formation. Journal of virology. 2014 May;88(88). 5319-27.
-
Freeman MC, Peek CT, Becker MM, Smith EC, Denison MR. Coronaviruses induce entry-independent, continuous macropinocytosis. MBio. 5(5). e01340-14.
-
Agnihothram S, Yount BL, Donaldson EF, Huynh J, Menachery VD, Gralinski LE, Graham RL, Becker MM, Tomar S, Scobey TD, Osswald HL, Whitmore A, Gopal R, Ghosh AK, Mesecar A, Zambon M, Heise M, Denison MR, Baric RS. A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant. MBio. 5(5). e00047-14.
2013
-
Stobart CC, Sexton NR, Munjal H, Lu X, Molland KL, Tomar S, Mesecar AD, Denison MR. Chimeric Exchange of Coronavirus nsp5 Proteases (3CLpro) Identifies Common and Divergent Regulatory Determinants of Protease Activity. Journal of virology. 2013 Dec;87(87). 12611-8.
-
Agnihothram S, Gopal R, Yount BL, Donaldson EF, Menachery VD, Graham RL, Scobey TD, Gralinski LE, Denison MR, Zambon M, Baric RS. Platform Strategies for Rapid Response Against Emerging Coronaviruses: MERS-CoV Serologic and Antigenic Relationships in Vaccine Design. The Journal of infectious diseases. 2013 Nov 18.
-
Smith EC, Blanc H, Vignuzzi M, Denison MR. Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics. PLoS pathogens. 2013 Aug;9(9). e1003565.
-
Beachboard DC, Lu X, Baker SC, Denison MR. Murine hepatitis virus nsp4 N258T mutants are not temperature-sensitive. Virology. 2013 Jan 20;435(435). 210-3. NIHMSID: NIHMS413905.
-
Smith EC, Denison MR. Coronaviruses as DNA wannabes: a new model for the regulation of RNA virus replication fidelity. PLoS pathogens. 9(9). e1003760.
2012
-
Graham RL, Becker MM, Eckerle LD, Bolles M, Denison MR, Baric RS. A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease. Nature medicine. 2012 Dec;18(18). 1820-6. NIHMSID: NIHMS408115.
-
Smith EC, Denison MR. Implications of altered replication fidelity on the evolution and pathogenesis of coronaviruses. Current opinion in virology. 2012 Oct;2(2). 519-24.
-
Stobart CC, Lee AS, Lu X, Denison MR. Temperature-sensitive mutants and revertants in the coronavirus nonstructural protein 5 protease (3CLpro) define residues involved in long-distance communication and regulation of protease activity. Journal of virology. 2012 May;86(86). 4801-10.
2011
-
Huang IC, Bailey CC, Weyer JL, Radoshitzky SR, Becker MM, Chiang JJ, Brass AL, Ahmed AA, Chi X, Dong L, Longobardi LE, Boltz D, Kuhn JH, Elledge SJ, Bavari S, Denison MR, Choe H, Farzan M. Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS pathogens. 7(7). e1001258.
2010
-
Gadlage MJ, Denison MR. Exchange of the coronavirus replicase polyprotein cleavage sites alters protease specificity and processing. Journal of virology. 2010 Jul;84(84). 6894-8.
-
Eckerle LD, Becker MM, Halpin RA, Li K, Venter E, Lu X, Scherbakova S, Graham RL, Baric RS, Stockwell TB, Spiro DJ, Denison MR. Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing. PLoS pathogens. 2010 May;6(6). e1000896.
-
Gadlage MJ, Sparks JS, Beachboard DC, Cox RG, Doyle JD, Stobart CC, Denison MR. Murine hepatitis virus nonstructural protein 4 regulates virus-induced membrane modifications and replication complex function. Journal of virology. 2010 Jan;84(84). 280-90.
2008
-
Becker MM, Graham RL, Donaldson EF, Rockx B, Sims AC, Sheahan T, Pickles RJ, Corti D, Johnston RE, Baric RS, Denison MR. Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice. Proceedings of the National Academy of Sciences of the United States of America. 2008 Dec 16;105(105). 19944-9.
-
Gadlage MJ, Graham RL, Denison MR. Murine coronaviruses encoding nsp2 at different genomic loci have altered replication, protein expression, and localization. Journal of virology. 2008 Dec;82(82). 11964-9.
-
Denison MR. Seeking membranes: positive-strand RNA virus replication complexes. PLoS biology. 2008 Oct 28;6(6). e270.
-
Sparks JS, Donaldson EF, Lu X, Baric RS, Denison MR. A novel mutation in murine hepatitis virus nsp5, the viral 3C-like proteinase, causes temperature-sensitive defects in viral growth and protein processing. Journal of virology. 2008 Jun;82(82). 5999-6008.
-
Graham RL, Sparks JS, Eckerle LD, Sims AC, Denison MR. SARS coronavirus replicase proteins in pathogenesis. Virus research. 2008 Apr;133(133). 88-100. NIHMSID: NIHMS88587.
2007
-
Sparks JS, Lu X, Denison MR. Genetic analysis of Murine hepatitis virus nsp4 in virus replication. Journal of virology. 2007 Nov;81(81). 12554-63.
-
Eckerle LD, Lu X, Sperry SM, Choi L, Denison MR. High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants. Journal of virology. 2007 Nov;81(81). 12135-44.
-
Deming DJ, Graham RL, Denison MR, Baric RS. Processing of open reading frame 1a replicase proteins nsp7 to nsp10 in murine hepatitis virus strain A59 replication. Journal of virology. 2007 Oct;81(81). 10280-91.
-
Donaldson EF, Graham RL, Sims AC, Denison MR, Baric RS. Analysis of murine hepatitis virus strain A59 temperature-sensitive mutant TS-LA6 suggests that nsp10 plays a critical role in polyprotein processing. Journal of virology. 2007 Jul;81(81). 7086-98.
-
Donaldson EF, Sims AC, Graham RL, Denison MR, Baric RS. Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesis. Journal of virology. 2007 Jun;81(81). 6356-68.
2006
-
Graham RL, Denison MR. Replication of murine hepatitis virus is regulated by papain-like proteinase 1 processing of nonstructural proteins 1, 2, and 3. Journal of virology. 2006 Dec;80(80). 11610-20.
-
Deming DJ, Graham RL, Denison MR, Baric RS. MHV-A59 ORF1a replicase protein nsp7-nsp10 processing in replication. Advances in experimental medicine and biology. 581(581). 101-4.
-
Graham RL, Sims AC, Baric RS, Denison MR. The nsp2 proteins of mouse hepatitis virus and SARS coronavirus are dispensable for viral replication. Advances in experimental medicine and biology. 581(581). 67-72.
-
Frieman MB, Yount B, Sims AC, Deming DJ, Morrison TE, Sparks J, Denison M, Heise M, Baric RS. SARS coronavirus accessory ORFs encode luxury functions. Advances in experimental medicine and biology. 581(581). 149-52.
-
Eckerle LD, Brockway SM, Sperry SM, Lu X, Denison MR. Effects of mutagenesis of murine hepatitis virus nsp1 and nsp14 on replication in culture. Advances in experimental medicine and biology. 581(581). 55-60.
2005
-
Yount B, Roberts RS, Sims AC, Deming D, Frieman MB, Sparks J, Denison MR, Davis N, Baric RS. Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice. Journal of virology. 2005 Dec;79(79). 14909-22.
-
Graham RL, Sims AC, Brockway SM, Baric RS, Denison MR. The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication. Journal of virology. 2005 Nov;79(79). 13399-411.
-
Brockway SM, Denison MR. Mutagenesis of the murine hepatitis virus nsp1-coding region identifies residues important for protein processing, viral RNA synthesis, and viral replication. Virology. 2005 Sep 30;340(340). 209-23.
-
Sperry SM, Kazi L, Graham RL, Baric RS, Weiss SR, Denison MR. Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice. Journal of virology. 2005 Mar;79(79). 3391-400.
2004
-
Denison MR. Severe acute respiratory syndrome coronavirus pathogenesis, disease and vaccines: an update. The Pediatric infectious disease journal. 2004 Nov;23(23). S207-14.
-
Brockway SM, Lu XT, Peters TR, Dermody TS, Denison MR. Intracellular localization and protein interactions of the gene 1 protein p28 during mouse hepatitis virus replication. Journal of virology. 2004 Nov;78(78). 11551-62.
-
Prentice E, McAuliffe J, Lu X, Subbarao K, Denison MR. Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins. Journal of virology. 2004 Sep;78(78). 9977-86.
-
Denison MR, Yount B, Brockway SM, Graham RL, Sims AC, Lu X, Baric RS. Cleavage between replicase proteins p28 and p65 of mouse hepatitis virus is not required for virus replication. Journal of virology. 2004 Jun;78(78). 5957-65.
-
Prentice E, Jerome WG, Yoshimori T, Mizushima N, Denison MR. Coronavirus replication complex formation utilizes components of cellular autophagy. The Journal of biological chemistry. 2004 Mar 12;279(279). 10136-41.
2003
-
Yount B, Curtis KM, Fritz EA, Hensley LE, Jahrling PB, Prentice E, Denison MR, Geisbert TW, Baric RS. Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus. Proceedings of the National Academy of Sciences of the United States of America. 2003 Oct 28;100(100). 12995-3000.
-
Brockway SM, Clay CT, Lu XT, Denison MR. Characterization of the expression, intracellular localization, and replication complex association of the putative mouse hepatitis virus RNA-dependent RNA polymerase. Journal of virology. 2003 Oct;77(77). 10515-27.
2002
-
Yount B, Denison MR, Weiss SR, Baric RS. Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59. Journal of virology. 2002 Nov;76(76). 11065-78.
2001
-
Bost AG, Prentice E, Denison MR. Mouse hepatitis virus replicase protein complexes are translocated to sites of M protein accumulation in the ERGIC at late times of infection. Virology. 2001 Jun 20;285(285). 21-9.
-
Denison MR, Sims AC. MHV-A59 gene 1 proteins are associated with two distinct membrane populations. Advances in experimental medicine and biology. 494(494). 655-61.
-
Prentice E, Denison MR. The cell biology of coronavirus infection. Advances in experimental medicine and biology. 494(494). 609-14.
2000
-
Sims AC, Ostermann J, Denison MR. Mouse hepatitis virus replicase proteins associate with two distinct populations of intracellular membranes. Journal of virology. 2000 Jun;74(74). 5647-54.
-
Bost AG, Carnahan RH, Lu XT, Denison MR. Four proteins processed from the replicase gene polyprotein of mouse hepatitis virus colocalize in the cell periphery and adjacent to sites of virion assembly. Journal of virology. 2000 Apr;74(74). 3379-87.
-
Denison MR, Graham RL, Donaldson EF, Eckerle LD, Baric RS. Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity. RNA biology. 8(8). 270-9.
-
Zhao Z, Thackray LB, Miller BC, Lynn TM, Becker MM, Ward E, Mizushima NN, Denison MR, Virgin HW. Coronavirus replication does not require the autophagy gene ATG5. Autophagy. 3(3). 581-5.
-
Van der Meer Y, Snijder EJ, Dobbe JC, Schleich S, Denison MR, Spaan WJ, Locker JK. Localization of mouse hepatitis virus nonstructural proteins and RNA synthesis indicates a role for late endosomes in viral replication. Journal of virology. 1999 Sep;73(73). 7641-57.
-
Denison MR, Spaan WJ, Van der Meer Y, Gibson CA, Sims AC, Prentice E, Lu XT. The putative helicase of the coronavirus mouse hepatitis virus is processed from the replicase gene polyprotein and localizes in complexes that are active in viral RNA synthesis. Journal of virology. 1999 Aug;73(73). 6862-71.
-
Lu XT, Sims AC, Denison MR. Mouse hepatitis virus 3C-like protease cleaves a 22-kilodalton protein from the open reading frame 1a polyprotein in virus-infected cells and in vitro. Journal of virology. 1998 Mar;72(72). 2265-71.
-
Sims AC, Lu XT, Denison MR. Expression, purification, and activity of recombinant MHV-A59 3CLpro. Advances in experimental medicine and biology. 440(440). 129-34.
-
Denison MR, Sims AC, Gibson CA, Lu XT. Processing of the MHV-A59 gene 1 polyprotein by the 3C-like proteinase. Advances in experimental medicine and biology. 440(440). 121-7.
-
Lu Y, Denison MR. Determinants of mouse hepatitis virus 3C-like proteinase activity. Virology. 1997 Apr 14;230(230). 335-42.
-
Lu X, Lu Y, Denison MR. Intracellular and in vitro-translated 27-kDa proteins contain the 3C-like proteinase activity of the coronavirus MHV-A59. Virology. 1996 Aug 15;222(222). 375-82.
-
Lu Y, Lu X, Denison MR. Identification and characterization of a serine-like proteinase of the murine coronavirus MHV-A59. Journal of virology. 1995 Jun;69(69). 3554-9.
-
Kim JC, Spence RA, Currier PF, Lu X, Denison MR. Coronavirus protein processing and RNA synthesis is inhibited by the cysteine proteinase inhibitor E64d. Virology. 1995 Apr 1;208(208). 1-8.
-
Denison MR, Hughes SA, Weiss SR. Identification and characterization of a 65-kDa protein processed from the gene 1 polyprotein of the murine coronavirus MHV-A59. Virology. 1995 Feb 20;207(207). 316-20.
-
Denison MR, Kim JC, Ross T. Inhibition of coronavirus MHV-A59 replication by proteinase inhibitors. Advances in experimental medicine and biology. 380(380). 391-7.
-
Weiss SR, Hughes SA, Bonilla PJ, Turner JD, Leibowitz JL, Denison MR. Coronavirus polyprotein processing. Archives of virology. Supplementum. 9(9). 349-58.
-
Hughes SA, Denison MR, Bonilla P, Leibowitz JL, Baric RS, Weiss SR. A newly identified MHV-A59 ORF1a polypeptide p65 is temperature sensitive in two RNA negative mutants. Advances in experimental medicine and biology. 342(342). 221-6.
-
Denison MR, Zoltick PW, Hughes SA, Giangreco B, Olson AL, Perlman S, Leibowitz JL, Weiss SR. Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events. Virology. 1992 Jul;189(189). 274-84.
-
Denison MR, Zoltick PW, Leibowitz JL, Pachuk CJ, Weiss SR. Identification of polypeptides encoded in open reading frame 1b of the putative polymerase gene of the murine coronavirus mouse hepatitis virus A59. Journal of virology. 1991 Jun;65(65). 3076-82.
-
Denison M, Perlman S. Identification of putative polymerase gene product in cells infected with murine coronavirus A59. Virology. 1987 Apr;157(157). 565-8.
-
Denison M, Perlman S. Translation and processing of MHV-A59 virion RNA in reticulocyte lysates and infected cells. Advances in experimental medicine and biology. 218(218). 155-6.
-
Denison MR, Perlman S. Translation and processing of mouse hepatitis virus virion RNA in a cell-free system. Journal of virology. 1986 Oct;60(60). 12-8.