Previous studies have shown that extrapulmonary TB is likely a marker of underlying immune compromise. Further study of the immune response of persons with previous extrapulmonary TB provides clues to the immune factors that predispose a person to progress from latent M. tuberculosis infection to clinical disease and contribute to TB prevention efforts by identifying potential targets for TB vaccines. Emerging evidence suggests a key component of the early response to infection with M. tuberculosis is Toll-like receptors. Vanderbilt researchers are working to better characterize the quantity and function of these receptors on immune system response in persons with various manifestations of TB.
| Christina Fiske [Email] Infectious Disease |
|
| Location | Nashville, TN, USA |
| Contacts | N/A |
| Program Type |
Research |
| Funding Type |
N/A |
| Region |
North America |
| Global Health Topics |
Basic Sciences, Infectious Diseases, Tuberculosis |
| Eligibility |
|
| Program Length |
|
| VU Affiliation |
The program is affiliated with Vanderbilt. |
| Language(s) |
The program does not have a language requirement. |