Ability of Acetaminophen to Prevent Oxidative Damage

I am collaborating with the Wellcome Trust Malaria Unit in Thailand exploring the ability of acetaminophen to inhibit hemoglobin redox cycling induced oxidative damage. There is a lot of hemolysis from the malaria parasite releasing free hemoglobin into the circulation. Free hemoglobin undergoes redox cycling which can cause severe oxidative damage to organs such as the kidneys. We discovered that acetaminophen (Tylenol) effectively prevents hemoglobin and myoglobin redox cycling - see our attached publication. The study is blinded so we don't yet know the outcome. 

Another project focuses on the development of a vaccine for malaria. Myself and Ray Mernaugh here at Vanderbilt are currently in conversations with Jane Kaye-Bailey who runs what is called TheButterflyTree.org in Africa. They are interested in eradicating malaria.