The Genetic Basis of Familial Colorectal Cancer Type X (FCCTX)

Dr. Leon Raskin (VICC member) is a PI of the NCI-funded (R00) ongoing study of genetic basis of familial colorectal cancer type X (FCCTX). The overall goal of the study is to identify new genes harboring rare mutations that considerably increase the risk of colorectal cancer. Dr. Raskin collaborates with a large ongoing study of Molecular Epidemiology of Colorectal Cancer (MECC) and Tel Aviv University from Israel to identify patients with FCCTX. The study employs next generation sequencing of at-risk individuals, genetic studies of families, population-based genetic epidemiology studies, and functional analysis of the identified genetic variants.