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Phelps HM, Pierce JM, Murphy AJ, Correa H, Qian J, Massion PP, Lovvorn HN. FXR1 expression domain in Wilms tumor. Journal of pediatric surgery. 2019 Jun;54(54). 1198-1205. NIHMSID: NIHMS1524314.
Abstract
Wilms tumor (WT) is the most common childhood kidney cancer globally. Our prior unbiased proteomic screen of WT disparities revealed increased expression of Fragile X-Related 1 (FXR1) in Kenyan specimens where survival is dismal. FXR1 is an RNA-binding protein that associates with poor outcomes in multiple adult cancers. The aim of this study therefore was to validate and characterize the FXR1 expression domain in WT.