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Han CS. Pregestational diabetes with extreme insulin resistance: use of U-500 insulin in pregnancy. Obstetrics and gynecology. 2012 Aug;120(120). 439-42.
Abstract
Increased insulin requirements in pregnancy can hinder attainment of glycemic control in diabetic patients. U-500 insulin is a concentrated form of regular insulin that can be a valuable tool in the treatment of patients with severe insulin resistance.