Imam Uddin, Ph.D.

Assistant Professor of Ophthalmology and Visual Sciences
Assistant Professor of Biomedical Engineering

 

Education

Ph.D., Applied Material Sciences, Kochi University, Japan

 

Professional Affiliations

Association for Research in Vision and Ophthalmology (ARVO)
International Society for Eye Research (ISER)
The American Chemical Society

 

Honors And Awards

National Eye Institute (NEI) Travel Fellowship (2016), Seattle, WA.  
Knights Templar Eye Foundation Travel Award (2016), Tokyo, Japan. 

 

 

Research Interests 

Dr. Uddin's research is focused on the development of molecular imaging technologies including optical imaging, optical coherence tomography (OCT) and nanoscale engineering to identify molecular targets for early disease detection and treatments in ophthalmology, vascular medicine and oncology. Dr. Uddin is currently using optical imaging techniques and nanotechnology-based approaches for diagnosis and drug delivery in preclinical models of diabetic retinopathy (DR), age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and retinal vein occlusion (RVO).

email:  md.i.uddin@vanderbilt.edu
web: https://wag.app.vanderbilt.edu/PublicPage/Faculty/Details/40613

 

ACADEMIC PRESENTATIONS

In vivo molecular imaging of endoglin mRNA using anti-sense shRNA-lipid bioconjugates as predictive biomarkers of neovascularization. Uddin, MI; Kilburn, TC; Penn JS. ARVO 2019, Vancouver, Canada. 

 

PATENTS APPLICATIONS

PATENT (assigned), Uddin, M. I.; Jayagopal, A.; Uddin, M.J.; Penn, J.S.; Marnett, L.J. (2016) Compositions and Method for Detecting Hypoxia. World Intellectual Property Organization, WO 2016/179117 A1.

PATENT (applied), Uddin, M. I.; Penn, J.S.; Duvall, CL. Methods for targeted delivery of shRNA-lipid bioconjugates to the ocular tissues for molecular imaging and gene silencing in vivo. United States Patent Application, 2019. 

 

BOOK CHAPTER

The Synthesis and Properties of Dipyrrins. Wood, T.E.; Uddin, M. I.; Thompson, A. “The Porphyrin Handbook” with applications to chemistry, physics, materials science, engineering, biology and medicine, Kadish, K.M.; Smith, K.; Guilard, R. (Eds.), 2010, 8, 235-291.

 

ACTIVE RESEARCH SUPPORT

(1)       National Institutes of Health, National Eye Institute   R01EY029693-01  

Title:     In Vivo Molecular Imaging of Vascular Disease of the Retina 

Role: Principal Investigator

Funding period (Approved): $ 2,098,330; Start date 03-1-2019 end date 02-29-2024. 

 

(2)       BrightFocus Foundation Macular Degeneration Research Grant

Title:     Hairpin-DNA functionalized nanoformulation for specific gene silencing in vivo in an animal model of age-related macular degeneration (AMD)

Role: Principal Investigator

Funding period (Approved): $ 200,000; 7/01/2019 to 06/30/2021.

 

(3) National Institutes of Health, National Eye Institute   R01EY023397-07 

Title: In Vivo Molecular Imaging of the Retina    

Role: Principal Investigator 

 

Funding period (Approved): $ 1,700,000; Start date 3-01-2013 end date 5-31-2023.

 

COMPLETED RESEARCH SUPPORT

(1)       National Institute of Health sponsored MICROMouse Program (MMPC), NIDDK Subcontract to Georgia Regents University   

Title:     In Vivo Imaging of Retinal Hypoxia in a Preclinical Model of Diabetic Retinopathy

Role: Principal Investigator

Funding period:           $ 75,000; Start date 1/01/2018 end date 12/31/2018.

 

(2)       Knights Templar Eye Foundation Pediatric Ophthalmology Career Starter Grant 

Title:     In vivo Imaging of Retinal Hypoxia in a Preclinical Model of Retinopathy of Prematurity

Role: Principal Investigator

Funding period: $ 130,000; 7/01/2016 to 03/31/2019.

PUBLICATIONS

  1. Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic 2 Targeting of COX‐1 in Ovarian Cancer. Uddin, M.J.; Wilson, A.J.; Crews, B.C.; Malerba, P.; Uddin, M.I.; Kingsley, P.J.; Ghebreselasie. K.; Daniel, C.K.; Nickels, M.L.; Tantawy, M.N.; Jashim, E.; Manning, H.C.; Khabele, D.; Marnett, L.J. ACS Omega, 2019, (Accepted).
  2. Targeted imaging of VCAM-1 mRNA in a mouse model of laser-induced choroidal neovascularization (LCNV) using antisense hairpin-DNA functionalized gold-nanoparticles. Uddin, M. I.; Kilburn, T.C.; Rong, Y.; McCollum, G.W.; Wright, D.W.; Penn, J.S. ACS Molecular Pharmaceutics, 2018, 15(12), 5514-5520.
  3. Real-time imaging of VCAM-1 mRNA in TNF-α activated retinal microvascular endothelial cells using antisense hairpin-DNA functionalized gold nanoparticles. Uddin, M. I.; Jayagopal, A.; Wong, A.; McCollum, G. W.; Wright, D. W.; Penn, J. S. Nanomedicine:NBM, 2018, 14(1), 63-71. 
  4. In Vivo Imaging of Retinal Hypoxia using HYPOX-4-dependent Fluorescence in a Mouse Model of Laser-induced Retinal Vein Occlusion (RVO). Uddin, M. I.; Jayagopal, A.; McCollum, G. W.; Rong, Y.; Penn, J. S. Invest. Ophthalmol. Vis. Sci. 2017, 58(9), 3818-3824.
  5. In Vivo Imaging of Retinal Hypoxia in a Model of Oxygen-Induced Retinopathy. Uddin, M. I.; Evans, S. M.; Craft, J. R.; Capozzi, M. E.; McCollum, G. W.; Yang, R.; Marnett, L. J.; Uddin, M. J.; Jayagopal, A.; Penn, J. S. Scientific Reports 2016, 6, 31011.
  6. Applications of azo-based probes for imaging retinal hypoxia. Uddin, M. I., Evans, S. M., Craft, J. R., Marnett, L. J., Uddin, M. J. Joyagopal, A. ACS Medicinal Chemistry Letters, 2015, 6 (4), 445-449. 
  7. Compositions and Method for Detecting Hypoxia. Uddin, M. I.; Jayagopal. A.; Uddin, M. J.; Penn, J. S.; Marnett, L. J. 2015, US 62/156,055.
  8. Gahlaut N, et al. (2015) Nanoengineering of therapeutics for retinal vascular disease. Gahlaut, N.; Suarez, S.; Uddin, M. I.; Gordon, A. Y.; Evans, S. M.; Jayagopal, A. Eur. J. Pharm. Biopharm. 2015, 95, 323-330.
  9. Synthesis and Antimalarial Activity of Prodigiosenes. Marchal; E.; Smithen, D. A.; Uddin M. I. Robertson, A. W.; Jakeman, D. J.; Mollard,.; MacDougall, K. S.; McFarland, S. A.; McFadden, G. I.; Thompson, A. Org. Biomol. Chem. 2014, 12, 4132-4142.  
  10. Microwave-Assisted, One-Pot Reactions of 7-Azaindoles and Aldehydes: A Facile Route to Novel Di-7-azaindolylmethanes. Uddin, M. I.; Buck, J. R.; Schulte, M. L.; Tang, D.; Saleh, S. A.; Yiu-Yin Cheung, Yiu-Yin.; Harp, J.; Manning, H. C. Tetrahedron Letters, 2014, 55, 169-173.
  11. Antimicrobial activity of non-natural prodigiosenes. Marchal, E.; Uddin, M. I.; Smithen, D. A.; Hawco, C. L. C.; Lanteigne, M.; Overy, D. P.; Keer, R. G.; Thompson, A. RSC Adv., 2013, 3, 22967-22971.
  12. Synthesis and biological evaluation of prodigiosene conjugates of porphyrin, estrone and 4-hydroxytamoxifen. Hawco, C.L.A., Marchal, E.; Uddin, M. I., Alexander E.G. Baker, Dale P. Corkery, Graham Dellaire, Alison Thompson. Bioorg. Med. Chem., 2013, 21, 5995-6002.
  13. Synthetic prodigiosenes and the influence of C-ring substitution on DNA cleavage, transmembrane chloride transport and basicity. Rastogi, S.; Marchal, E.; Uddin, M. I.; Groves, B.; Colpitts, J.; McFarland, S.A.; Jeffery T. Davis, J.T.; Thompson, A. Org. Biomol. Chem., 2013,11, 3834-3845.
  14. Synthesis and Structure–Activity Relationships of 5,6,7-Substituted Pyrazolopyrimidines: Discovery of a Novel TSPO PET Ligand for Cancer Imaging. Dewei Tang, Eliot T. McKinley, Matthew R. Hight, Uddin, M. I., Joel M. Harp, Allie Fu, Michael L. Nickels, Jason R. Buck, and H. Charles Manning. J. Med. Chem. 2013, 56, 3429−3433. Plus cover art chosen by The American Chemical Society.
  15. 3′-Deoxy-3′-18F-Fluorothymidine PET Predicts Response to V600EBRAF-Targeted Therapy in Preclinical Models of Colorectal Cancer. Eliot T. McKinley, R. Adam Smith, Ping Zhao, Allie Fu, Samir A. Saleh, Uddin, M. I., M. Kay Washington, Robert J. Coffey, and H. Charles Manning. J. Nucl. Med. 2013, 54, 424-430.
  16. Synthesis of Heteroleptic Pyrrolide/Bipyridyl Complexes of Ruthenium(II). Lundrigan, T.; Jackson, C.L.M.; Uddin, M. I.; Tucker, L.A. ; Al-Sheikh Ali, A.; Linden, A.; Cameron, T.S.; Thompson, A. Can. J. Chem. 2012, 90, 693-700. 
  17. Rapid, Microwave-Assisted Organic Synthesis of Selective V600EBRAF Inhibitors for Preclinical Cancer Research. Buck, J. R.; Saleh, S.; Uddin, M. I.; Manning, H. C. Tetrahedron Letters, 2012, 53, 4161-4165.
  18. Improved synthetic route to C-ring ester-functionalized prodigiosenes. Uddin, M. I., Thirumalairajan, S; Crawford, S. M.; Cameron, T. S.; Thompson, A. Synlett, 2010, 17, 2561-2564.
  19. Microwave-assisted and Ln(OTf)3-catalyzed Homo-conjugate Addition of N-Heteroaromatics to Activated Cyclopropane Derivatives. Uddin, M. I.; Mimoto, A.; Nakano, K.; Ichikawa, Y.; Kotsuki, H. Tetrahedron Letters, 2008, 49, 5867-5870.
  20. A Novel Method for the High-Pressure-Promoted Uncatalyzed Aza-Michael Reaction of Nitrogen Heterocycles with Enones in Water. Uddin, M. I.; Nakano, K.; Ichikawa, Y.; Kotsuki, H. Synlett, 2008, 9, 1402-1406.
  21. Synthesis and preliminary evaluation of brominated 5-methyl-2,4-dihydropyrazol-3-one and its derivatives as cytotoxic agents. Rahat Khan, Uddin M. I.; Alam, S. M.; Hossain, M. M.;  Islam, R. I. Bangladesh J. Pharmacol, 2008, 3, 27-35. 
  22. A novel design of roof-shaped anthracene-fused chiral prolines　as organocatalysts for asymmetric Mannich reactions. Sasaoka, A.; Uddin, M. I.; Shimomoto, A.; Ichikawa, Y.; Shiro, M.; Kotsuki, H. Tetrahedron: Asymmetry 2006, 17, 2963-2969.