Carlos Henrique Serezani, Ph.D.
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Understanding host defense in pre-existing inflammatory conditions
Dr. Serezani completed his PhD at the University of Sao Paulo and the University of Michigan. He also completed his postdoctoral studies at University of Michigan. He was an Assistant Professor at Indiana University School of Medicine and has published more than 50 papers in reputed journals. The NIH and other foundations have funded his laboratory for almost 10 years. The Serezani laboratory aims to develop therapeutic strategies to control systemic (sepsis) and localized infections (skin and lung) in healthy individuals, individuals with immune deficiencies, and those suffering from chronic inflammatory diseases, such as diabetes. They have concentrated much of their efforts on understanding the role of the lipid mediators leukotriene B4 and prostaglandin E2 and their actions on microRNAs and phosphatases to modulate immune cells involved in the control of microbial infection in these different contexts.
Research Information
The Serezani laboratory aims to develop therapeutic strategies to control systemic (sepsis) and localized infections (skin and lung) in healthy individuals, individuals with immune deficiencies, and those suffering from chronic inflammatory diseases, such as diabetes. We have concentrated much of our efforts in understanding the role of the lipid mediators leukotriene B4 and prostaglandin E2 and their actions on microRNAs, epigenetic changes and phosphatases to modulate immune cells involved in the control of microbial infection in these different contexts. Our lab employ state of the art techniques to understand in vitro and in vivo cellular and microbial dynamics, such as intravital microscopy and IVIS imaging, along with different fluorescent and cell-specific deficient mice to track cell and organ-specific events.
