Jeff Reese, MD

Our laboratory is interested in the molecular mechanisms of embryo implantation and other aspects of reproduction. In particular, we are focused on the contribution of prostaglandins and other eicosanoids to the reproductive process. Prostaglandins are key molecules in ovulation, fertilization, implantation, decidualization, and overall control of the parturition process. I have an extended research background in reproductive biology and the role of prostaglandins in reproduction and fetal vascular development. We use Cox1, Cox2, cPLA2, prostaglandin receptor knockout mice, and other transgenic or pharmacologic models of prostaglandin deficiency. Our collaborative studies on the role of prostaglandins in cancer, atherosclerosis, cardiovascular homeostasis and neurobehavioral function reflect our broad-based approach to studies on prostaglandin biology.