Bibhash C. Paria, PhD

Dr. Bibhash C. Paria is one of the members of the Interdisciplinary Collaborative Team for Blastocyst Implantation Research formed by the National Institutes of Health NIAID and NICHD. The focus of the Paria laboratory is to understand the basic mechanisms of embryo implantation, decidualization and pregnancy protection. The two research areas of particular interest include: 1) Signaling molecules involved in the initiation of progesterone-dependent implantation in hamsters and 2) Mechanisms of protecting the implanting embryo from maternal dangers.  First, the Paria laboratory utilizes a hamster modeling system to decipher the signaling molecules involved in the initiation of progesterone-dependent implantation. His studies suggest the existence of an alternate source of estrogen beside the ovary in hamsters. Secondly, the Paria laboratory explores the influence of implanting blastocyst in creation of a uterine decidual barrier to escape from maternal dangers. Moreover, they investigate the novel use of alkaline phosphatase as a therapeutic strategy to augment bacterial endotoxin-induced early pregnancy loss/defects, as well as preterm birth.