Autoimmunity and Inflammation

Autoimmunity and Tolerance.jpg

-Boothby Lab, Serezani Lab

Autoimmunity and Inflammation

The immune system must balance the maintenance of a capacity to eliminate an infinite array of pathogens with the necessity to not induce an immune response against oneself. Insufficient or excessive immune responses can lead to immune deficiencies, autoimmunity, or autoinflammatory syndromes. VCI members are exploring the cellular and genetic basis for these immune dysregulation disorders to better understand basic immunology and mechanisms of immune-related diseases.

Danyvid Olivares-Villagomez, Ph.D.

Assistant Professor of Pathology, Microbiology and Immunology

Mucosal immunology, IEL, iCD8alpha, osteopontin, granzyme

Dawn C. Newcomb, Ph.D.

Assistant Professor of Medicine

Assistant Professor of Pathology, Microbiology and Immunology

Estrogen, testosterone, sex hormones, T cells, innate lymphoid cells, asthma, allergy

Dolly Ann Padovani- Claudio, M.D., Ph.D.

Assistant Professor of Ophthalmology and Visual Sciences

Vascular diseases of the retina

Daniel J. Moore, Ph.D., M.D.

Assistant Professor of Pediatrics

Assistant Professor of Pathology, Microbiology and Immunology

Immune regulation in autoimmunity and transplantation

Amy S. Major, Ph.D.

Associate Professor of Medicine

Associate Professor of Pathology, Microbiology and Immunology

Immunological mechanisms of autoimmunity in atherosclerosis

Ken S. Lau, Ph.D.

Assistant Professor of Cell and Developmental Biology

Single-cell, computational systems biology, inflammation, colorectal cancer, stem cells, epithelial biology, cell state specification, signal transduction

Matthew J Lang, Ph.D.

Professor of Chemical and Biomolecular Engineering

Professor of Molecular Physiology and Biophysics

Biological motors, Cell signaling and immunology

Meena S. Madhur, M.D., Ph.D.

Associate Director, (VI4), Institute for Infection, Immunology and Inflammation

Assistant Professor of Medicine

Assistant Professor of Molecular Physiology and Biophysics

The role of T cells and T cell-derived cytokines in hypertension and renal/vascular dysfunction

Simon A. Mallal, M.B.B.S.

Professor of Medicine

Major E.B. Stahlman Chair in Infectious Diseases and Inflammation

Professor of Pathology, Microbiology and Immunology

Immunometabolism & Metabolic Diseases, Tumor Biology & Tumor Immunology

Heather H. Pua, M.D., Ph.D.

Assistant Professor of Pathology, Microbiology and Immunology

Lung, miRNA, exRNA (extracellular RNA), extracellular vesicles, allergy, asthma, Th2

Henry Charles Manning, Ph.D.

Professor of Radiology and Radiological Sciences

Ingram Associate Professor of Cancer Research

Professor of Chemistry and Biomedical Engineering

Professor in Neurological Surgery

Non-invasive molecular imaging metrics to assess disease progression and response to therapy

Jeffrey C. Rathmell, Ph.D.

Professor of Pathology, Microbiology and Immunology

Professor of Molecular Physiology & Biophysics

Cornelius Vanderbilt Chair in Immunobiology

T cell metabolism in inflammation and anti-tumor immunity

Luc Van Kaer, Ph.D.

Elizabeth and John Shapiro Chair

Professor of Pathology, Microbiology and Immunology

Role of innate-type regulatory lymphocytes in health and chronic inflammatory diseases

James W. Thomas II, M.D.

Professor of Medicine

Professor of Pathology, Microbiology and Immunology

Mechanisms that regulate immune tolerance and why they fail in autoimmune disorders such at type 1 diabetes

Charles F. Spurlock, III, Ph.D.

Research Instructor in Medicine

long non-coding RNAs, autoimmune disease, RNA biology, RNA sequencing, adaptive immune system, T cells, gene regulation

Mark R. Boothby, M.D., Ph.D.

Professor of Pathology, Microbiology and Immunology

Professor of Medicine

Signal transduction, transcription regulation mechanisms

Jim Connelly, M.D.

Assistant Professor of Pediatrics

Pediatric Hematology/Oncology, immunodeficiency, and inborn errors of immunity

Rebecca S. Muraoka Cook, Ph.D.

Assistant Professor of Cell & Developmental Biology

Assistant Professor of Biomedical Engineering

Signaling pathways induced by the ErbB family of receptor tyrosine kinases

Leslie J. Crofford, M.D.

Professor of Medicine

Professor of Pathology, Microbiology and Immunology

Director, Division of Rheumatology & Immunology

Wilson Family Chair in Medicine

Innate and acquired immunity in inflammatory arthritis, myositis, scleroderma, fibromyalgia, pain

Rachel Henry Bonami, Ph.D.

Assistant Professor of Medicine

B cell, T cell, autoimmunity, type 1 diabetes, arthritis, microbiome

David Michael Aronoff, M.D.

Director, Division of Infectious Diseases

Professor of Obstetrics & Gynecology

Professor of Pathology, Microbiology and Immunology

Addison B. Scoville Jr. Chair in Medicine

Mechanisms of bacterial immune evasion in the female reproductive tract

Thomas M. Aune, Ph.D.

Professor of Medicine

Associate Professor of Pathology, Microbiology and Immunology

Functional genomic and epigenetic approaches to understand gene regulation

Manuel Ascano, Ph.D.

Assistant Professor of Biochemistry

Assistant Professor of Pathology, Microbiology and Immunology

Post-transcriptional gene regulation in innate immunity and cellular stress

Wonder Puryear Drake, M.D.

Professor of Pathology, Microbiology and Immunology

Molecular biolody and immunopathogenesis of chronic inflammatory states, particularly sarcoidosis

Alyssa H. Hasty, Ph.D.

Associate Dean for Faculty Development for Basic Sciences

Professor of Molecular Physiology and BiophysicsCornelius

Vanderbilt Chair in Molecular Physiology and Biophysics

Mechanisms by which obesity increases risk for disease

David Glenn Harrison, M.D.

Director, Division of Clinical Pharmacology

Professor of Medicine

Betty and Jack Bailey Chair in Cardiology

Professor of Molecular Physiology & Biophysics

Professor of Pharmacology

How inflammation and the adaptive immune response contributes to hypertension

Jonathan M. Irish, Ph.D.

Assistant Professor of Cell & Developmental Biology

Assistant Professor of Pathology, Microbiology and Immunology

Cancer, precision medicine, computational biology, machine learning, cell signaling, chemical biology, single cell tools

Sebastian Joyce, Ph.D.

Professor of Pathology, Microbiology and Immunology

Dorothy B. and Theodore R. Austin Chair in Pathology

Antigen presentation and recognition by immune cells

Jeremy Allen Goettel, Ph.D.

Assistant Professor of Medicine

Assistant Professor of Pathology, Microbiology and Immunology

Mechanisms regulating intestinal immunity

Craig Duvall, Ph.D.

Associate Professor of Biomedical Engineering

Director of Graduate Recruiting in Biomedical Engineering

Surgery and engineering, Nano science and Technology, Regenerative Medicine