The fields of infection biology, immunobiology and inflammation research is varied and ever-expanding. Researchers the world over are making discoveries that contribute greatly to our collective understanding of health and disease. VI4 is committed to providing our members, students, and community resources to aid in knowledge-building in these core VI4 research areas. Please check out our current curated recommended reading list below from scientists across the country!
Recommended Reading - April 4, 2021
- Metabolic RNA labeling for probing RNA dynamics in bacteria. Meng L, et al. in Nucleic Acids Research, December 16, 2020
- Infection trains the host for microbiota-enhanced resistance to pathogens. Stacy A, et al. in Cell, January 15, 2021
- The Identity of Human Tissue-Emigrant CD8+ T Cells. Buggert M, et al. in Cell, December 10, 2020
- Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes. Bedford J, et al. in Science Immunology, October 9, 2020
- Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells. Baharom F, et al. in Nature Immunology, November 2, 2020
Recommended Reading - March 7, 2021
- Reduced Lymphatic Reserve in Heart Failure With Preserved Ejection Fraction. Rossitto G, et al. in Journal of the American College of Cardiology, December 15, 2020
- Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin. Russo A, et al. in Nature Immunology, January 21, 2021
- Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination. Yu J, et al. in Nature Medicine, January 4, 2021
- Metformin Preserves β-Cell Compensation in Insulin Secretion and Mass Expansion in Prediabetic Nile Rats. Huang H, et al. in International Journal of Molecular Sciences, January 3, 2021
- Local immune response to food antigens drives meal-induced abdominal pain. Aguilera-Lizarraga J, et al. in Nature, January 13, 2021
Recommended Reading - February 1, 2021
- Fusobacterium nucleatum adheres to Clostridioides difficile via the RadD adhesin to enhance biofilm formation in intestinal mucus. Engevik M, et al. in Gastroenterology, November 20, 2020
- Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. Turner J, et al. in Cell Immunity, October 20, 2020
- Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Minhas P, et al. in Nature, January 20, 2021
- Tetracycline Antibiotics Induce Host-Dependent Disease Tolerance to Infection. Colaco H, et al. in Cell Immunity, October 14, 2020
- Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis. Leimkuhler N, et al. in Cell Stem Cell, December 9, 2020
Recommended Reading - January 3rd, 2021
- Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense. Bosch M, et al. in Science, October 16, 2020
- Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms. Beltra JC, et al. in Immunity, May 19, 2020
- T cells with dysfunctional mitochondria induce multimorbidity and premature senescence. Desdin-Mico G, et al. in Science, June 19, 2020
- Commensal Microbiota Modulation of Natural Resistance to Virus Infection. Stefan K, et al. in Cell, November 25, 2020
- The cancer microbiome atlas: a pan-cancer comparative analysis to distinguish tissue-resident microbiota from contaminants. Dohlman A, et al. in Cell Host & Microbe, December 30, 2020
Recommended Reading - October 4th, 2020
- Dendritic cell–derived hepcidin sequesters iron from the microbiota to promote mucosal healing. Bessman N, et al. in Science, April 10, 2020
- Unsupervised machine learning reveals risk stratifying glioblastoma tumor cells. Leelatian N, et al. in eLife, June 23, 2020
- Glycogen metabolism regulates macrophage-mediated acute inflammatory responses. Ma J, et al. in Nature Communications, April 14, 2020
- Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals. Grifoni A, et al. in Cell, June 25, 2020
- Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes. Edner N M, et al. in Nature Immunology, August 3, 2020
Recommended Reading - August 2nd, 2020
- A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii. Luna B, et al. in Nature Microbiology, June 8, 2020
- SARS-CoV-2 infection protects against rechallenge in rhesus macaques. Chandrashekar A, et al. in Science, May 20, 2020
- Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation. Sinha S, et al. in Cell Host & Microbe, April 8, 2020
- The human tumor microbiome is composed of tumor type-specific intracellular bacteria. Nejman D, et al. in Science, May 29, 2020
- Bcl6 and Blimp1 Reciprocally Regulate ST2 + Treg-cell Development in the Context of Allergic Airway Inflammation. Koh B, et al. in The Journal of Allergy and Clinical Immunology, March 13, 2020
Recommended Reading - July 5th, 2020
- An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sheahan T, et al. in Science Translational Medicine, April 6, 2020
- Spatially Distinct Physiology of Bacteroides Fragilis Within the Proximal Colon of Gnotobiotic Mice. Donaldson G, et al. in Nature Microbiology, March 9, 2020
- Evolution of multifunctionality through a pleiotropic substitution in the innate immune protein S100A9. Harman J, et al. in eLife, April 7, 2020
- DNA vaccine protection against SARS-CoV-2 in rhesus macaques. Jingyou Y, et al. in Science, May 20, 2020
- ILC2s Amplify PD-1 Blockade by Activating Tissue-Specific Cancer Immunity. Moral JA, et al. in Nature, February 19, 2020
Recommended Reading - June 7th, 2020
- Sex-specific adipose tissue imprinting of regulatory T cells. Vasanthakumar A, et al. in Nature, February 26, 2020
- Metabolites released from apoptotic cells act as tissue messengers. Medina C, et al. in Nature, March 18, 2020
- Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation. Zhu J, et al. in Cell Metabolism, November 5, 2019
- Decoy exosomes provide protection against bacterial toxins. Keller M D, et al. in Nature, March 4, 2020
- Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity. McGinty J, et al. in Cell Press, March 17, 2020
- Collective Viral Spread Mediated by Virion Aggregates Promotes the Evolution of Defective Interfering Particles.. Andreu-Moreno, Sanjuan, Rafael in American Society for Microbiology Journal, January 7, 2020
- JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor. O'Hara BA, et al. in PLOS Pathogens, March 4, 2020
- Fecal IgA Levels Are Determined by Strain-Level Differences in Bacteroides Ovatus and Are Modifiable by Gut Microbiota Manipulation. Yang C, et al. in Cell Host & Microbe, February 18, 2020
- Long-term dietary intervention reveals resilience of the gut microbiota despite changes in diet and weight. Fragiadais G, et al. in The American Journal of Clinical Nutrition, March 18, 2020
- Commensal Bacteria Modulate Immunoglobulin A Binding in Response to Host Nutrition. Huus K, et al. in Cell Host & Microbe, April 13, 2020
Recommended Reading - May 3rd, 2020
- N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I. Lu M, et al. in Nature, April 5, 2020
- Targeted selection of HIV-specific antibody mutations by engineering B cell maturation. Saunders K, et al. in Science, December 6, 2019
- Transcriptomic and epigenetic mechanisms underlying myeloid diversity in the lung. Sajti E, et al. in Nature Immunology, January 20, 2020
- B cells and tertiary lymphoid structures promote immunotherapy response. Helmink B, et al. in Nature, January 15, 2020
- c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies. Bernink J, et al. in Nature Immunology, November 13, 2019
- Structure‐Guided Design of a Group B Streptococcus Type III Synthetic Glycan–Conjugate Vaccine. Oldrini D, et al. in Chemistry Europe, February 14, 2020
- Antirotavirus IgA seroconversion rates in children who receive concomitant oral poliovirus vaccine: A secondary, pooled analysis of Phase II and III trial data from 33 countries. Baker JM, et al. in PLOS Medicine, December 30, 2019
- An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products. de Los Reyes J M, et al. in Science, April 22, 2020
- Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. Pleguezuelos-Manzano C, et al. in Nature, February 27, 2020
- Antibiotic Degradation by Commensal Microbes Shields Pathogens. Gjonbalaj M, et al. in American Society for Microbiology Journal, January 14, 2020
Recommended Reading - April 5th, 2020
- Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Wrapp D, et al. in Science, March 13, 2020
- MAIT cells are imprinted by the microbiota in early life and promote tissue repair. Constantinides, M, et al. in Science, October 25, 2019
- Optogenetic manipulation of calcium signals in single T cells in vivo. Bohineust A, et al. in Nature, March 2, 2020
- Live-animal imaging of native haematopoietic stem and progenitor cells. Christodoulou C, et al. in Nature, February 5, 2020
- Targeting of temperate phages drives loss of type I CRISPR–Cas systems. Rollie C, et al. in Nature, January 22, 2020
- Combinatorial selection in amoebal hosts drives the evolution of the human pathogen Legionella pneumophila. Park J, et al. in Nature, January 27, 2020
- Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion. Leone R, et al. in Science, Novemeber 22, 2019
- Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells. Wang X, et al. in Immunity, February 11, 2020
- Enhanced immunogenicity of mitochondrial-localized proteins in cancer cells. Prota G, et al. in Cancer Immunology Research, March 12, 2020
- Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism. Duscha A, et al. in ScienceDirect, March 19, 2020
