The fields of infection biology, immunobiology and inflammation research is varied and ever-expanding. Researchers the world over are making discoveries that contribute greatly to our collective understanding of health and disease. VI4 is committed to providing our members, students, and community resources to aid in knowledge-building in these core VI4 research areas. Please check out our current curated recommended reading list below from scientists across the country!
Recommended Reading - August 7th, 2022
- Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3. Grebinoski S, et al. in Nature Immunology, May 26, 2022
- Mapping the developing human immune system across organs. Suo C, et al. in Science, June 7, 2022
- Pregnancy enables antibody protection against intracellular infection. Erickson J, et al. in Nature, June 8, 2022
- Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1. McCulloch J, et al. in Nature Medicine, February 28, 2022
- Tissue remodeling by an opportunistic pathogen triggers allergic inflammation. Agaronyan K, et al. in Immunity, May 10, 2022
Recommended Reading - July 10th, 2022
- Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice. Hunt A, et al. in Science Translational Medicine, April 12, 2022
- Intramuscular AZD7442 (Tixagevimab– Cilgavimab) for Prevention of Covid-19. Levin MJ, et al. in The New England Journal of Medicine, April 20, 2022
- Neoantigen quality predicts immunoediting in survivors of pancreatic cancer. Luksza M, et al. in Nature, May 19, 2022
- Host hepatic metabolism is modulated by gut microbiota-derived sphingolipids. Le HH, et al. in Cell Host & Microbe, June 8, 2022
- Extracellular vesicles from lung tissue drive bone marrow neutrophil recruitment in inflammation. Liu B, et al. in Journal of Extracellular Vesicles, May 20, 2022
Recommended Reading - June 7th, 2022
- Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation. Cautivo K, et al. in Immunity, February 8, 2022
- Immunosuppression broadens evolutionary pathways to drug resistance and treatment failure during Acinetobacter baumannii pneumonia in mice. Huo W, et al. in Nature Microbiology, May 26, 2022
- Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces. Maeda K, et al. in Cell Host & Microbe, February 9, 2022
- Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus. Shinzawa M, et al. in Nature Immunology, April 29, 2022
- Human gut bacteria produce ΤΗ17-modulating bile acid metabolites. Paik D, et al. in Nature, March 16, 2022
Recommended Reading - May 8th, 2022
- Structure of a bacterial Rhs effector exported by the type VI secretion system. Gunther P, et al. in PLOS Pathogen, January 5, 2022
- Maternal inflammation is hard for offspring to stomach. Zengeler KE, Lukens JR. in Immunity, January 11, 2022
- The vulnerable versatility of Salmonella antibiotic persisters during infection. Hill P, et al. in Cell Host & Microbe, December 8, 2021
- Diverse events have transferred genes for edible seaweed digestion from marine to human gut bacteria. Pudlo N, et al. in Cell Host & Microbe, March 9, 2022
- Mechanistic insights into consumption of the food additive xanthan gum by the human gut microbiota. Ostrowski M, et al. in Nature Microbiology, April 1, 2022
Recommended Reading - April 10, 2022
- Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement. McCallum M, et al. in Science, January 25, 2022
- TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures. Chaurio R, et al. in Immunity, January 11, 2022
- KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19. Jing L, et al. in Science, March 8, 2022
- Single-cell transcriptional profiling informs efficient reprogramming of human somatic cells to cross-presenting dendritic cells. Fabio R, et al. in Science Immunology, March 4, 2022
- Rare and localized events stabilize microbial community composition and patterns of spatial self-organization in a fluctuating environment. Ciccarese D, et al. in The ISME Journal, January 25, 2022
Recommended Reading - March 6th, 2022
- T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma. Lozano A, et al. in Nature Medicine, January 13, 2022
- Bacterial gasdermins reveal an ancient mechanism of cell death. Johnson A, et al. in Science, January 13, 2022
- Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Simpson D, et al. in Immunity, February 8, 2022
- Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite. Park SY, et al. in Cell, January 2, 2022
- A SARS-CoV-2 ferritin nanoparticle vaccine elicits protective immune responses in nonhuman primates. Joyce G, et al. in Science Translational Medicine, December 16, 2021
Recommended Reading - February 6th, 2022
- Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis. Hinrichsen F, et al. in Cell Metabolism, December 7, 2021
- Establishment and characterization of stable, diverse, fecal-derived in vitro microbial communities that model the intestinal microbiota. Aranda-Diaz A, et al. in Cell Host & Microbe, January 19, 2022
- Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells. Kim E, et al. in Immunity, January 11, 2022
- An autoimmune stem-like CD8 T cell population drives type 1 diabetes. Gearty S, et al. in Nature, November 30, 2021
- The UGT2A1/UGT2A2 locus is associated with COVID-19-related loss of smell or taste. Shelton J, et al. in Nature Genetics, January 17, 2022
Recommended Reading - January 9th, 2022
- Mapping the cellular origin and early evolution of leukemia in Down syndrome. Wagenblast E, et al. in Science, July 9, 2021
- Arthritis flares mediated by tissue-resident memory T cells in the joint. Chang M, et al. in Cell Reports, October 26, 2021
- An autoimmune stem-like CD8 T cell population drives type 1 diabetes. Gearty S, et al. in Nature, November 30, 2021
- Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer. Overacre-Delgoffe A, et al. in Immunity, December 2, 2021
- Heme-Dependent Siderophore Utilization Promotes Iron-Restricted Growth of the Staphylococcus aureus hemB Small-Colony Variant. Batko I, et al. in Journal of Bacteriology, November 19, 2021
Recommended Reading - December 19, 2021
- Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy. Bentires-Alj M et al. in Nature, June 2, 2021
- Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis. Jul`e A, et al. in JCI Insight, September 22, 2021
- The lungfish cocoon is a living tissue with antimicrobial functions. Heimroth R, et al. in Science Advances, November 17, 2021
- Human gut bacterial metabolism drives Th17 activation and colitis. Alexander M, et al. in Cell Host & Microbe, November 24, 2021
- γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans. Chu T, et al. in PLOS Pathogens, December 6, 2021
Recommended Reading - November 14, 2021
- Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers. Caushi J, et al. in Nature Biotechnology, July 21, 2021
- An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer. Voabil P, et al. in Nature, July 8, 2021
- Obesity results in adipose tissue T cell exhaustion. Porshe C, et al. in Science, April 22, 2021
- Diet-regulated production of PDGFcc by macrophages controls energy storage. Cox N, et al. in Nature Ecology & Evolution, July 2, 2021
- Maturation of the matrix and viral membrane of HIV-1. Qu K, et al. in Cell Host & Microbe, August 6, 2021
