The fields of infection biology, immunobiology and inflammation research is varied and ever-expanding. Researchers the world over are making discoveries that contribute greatly to our collective understanding of health and disease. VI4 is committed to providing our members, students, and community resources to aid in knowledge-building in these core VI4 research areas. Please check out our current curated recommended reading list below from scientists across the country!
Recommended Reading - October 3, 2021
- MHC class II tetramers engineered for enhanced binding to CD4 improve detection of antigen-specific T cells. Evavold B & Jenkins M et al. in Nature Biotechnology, May 23, 2021
- Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity. Mwakingwe-Omari A, Et al. in Nature, June 30, 2021
- SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell–mediated immunity. Yue T, et al. in Science, May 14, 2021
- Obligate cross-feeding expands the metabolic niche of bacteria. Oña L. Et al. in Nature Ecology & Evolution, July 15, 2021
- Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis. Koehler H, et al. in Cell Host & Microbe, August 11, 2021
Recommended Reading - September 27, 2021
- Exercise training improves tumor control by increasing CD8+ T-cell infiltration via CXCR3 signaling and sensitizes breast cancer to immune checkpoint blockade. Fukumura K et al. in Cancer Immunology Research, April 10, 2021
- A microRNA expression and regulatory element activity atlas of the mouse immune system. Brown B et al. in Nature Immunology, June 7, 2021
- Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy. Beziat V, et al. in Cell, July 8, 2021
- Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas. Friedrich M, et al. in Nature Cancer, May 24, 2021
- Bifidobacteria-mediated immune system imprinting early in life. Hendrick B, et al. in Cell, July 22, 2021
Recommended Reading - August 15, 2021
- SorTn-seq: a high-throughput functional genomics approach to discovering regulators of bacterial gene expression. Fineran P et al. in Nature Protocols, August 4, 2021
- Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity. Duffy P et al. in Nature, June 30, 2021
- An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer . Thommen D et al. in Nature Medicine, July 8, 2021
- Introducing the Microbes and Social Equity Working Group: Considering the Microbial Components of Social, Environmental, and Health Justice . Morar n et al. in mSystems, July 27, 2021
- Matrix-trapped viruses can prevent invasion of bacterial biofilms by colonizing cells. Nadell C et al. in eLife, July 9, 2021
Recommended Reading - July 18th, 2021
- Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients. Baruch E, et al. in Science, February 5, 2021
- Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid. Heming M, et al. in Cell Immunity, January 12, 2021
- Human NLRP1 is a sensor for double-stranded RNA. Bauernfried S, et al. in Science, January 29, 2021
- Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression. DChen S, et al. in Nature Cell Biology, January 8, 2021
- A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression. Ostuni R et al. in Cell Immunity, June 14, 2021
Recommended Reading - June 6th, 2021
- The gut microbiota is associated with immune cell dynamics in humans. Schluter J, et al. in Nature, December 1, 2020
- Rapid transcriptional and metabolic adaptation of intestinal microbes to host immune activation. Becattini S, et al. in Cell Host & Microbe, March 10, 2021
- Hyperglycemic Memory of Innate Immune Cells Promotes In Vitro Proinflammatory Responses of Human Monocytes and Murine Macrophages. Thiem K, et al. in The Journal of Immunology, January 11, 2021
- Bacterial-driven inflammation and mutant BRAF expression combine to promote murine colon tumorigenesis that is sensitive to immune checkpoint therapy. DeStefano Shields C, et al. in Cancer Discovery, February 25, 2021
- Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling. Hormaechea-Agulla D, et al. in Cell Stem Cell, March 19, 2021
Recommended Reading - May 2nd, 2021
- Exhausted-like CD8 T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects. Diggins K, et al. in JCI Insight, December 22, 2020
- Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity. Montgomery T, et al. in Proceedings of the National Academy of Sciences, November 3, 2020
- Wisp1 is a circulating factor that stimulates proliferation of adult mouse and human beta cells. Fernandez-Ruiz, et al. in Nature Communications, November 25, 2020
- Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage. Johnnidis J, et al. in Science Immunology, January 15, 2021
- Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets. Gong Y, et al. in Cell Metabolism, January 5, 2021
Recommended Reading - April 4, 2021
- Metabolic RNA labeling for probing RNA dynamics in bacteria. Meng L, et al. in Nucleic Acids Research, December 16, 2020
- Infection trains the host for microbiota-enhanced resistance to pathogens. Stacy A, et al. in Cell, January 15, 2021
- The Identity of Human Tissue-Emigrant CD8+ T Cells. Buggert M, et al. in Cell, December 10, 2020
- Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes. Bedford J, et al. in Science Immunology, October 9, 2020
- Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells. Baharom F, et al. in Nature Immunology, November 2, 2020
Recommended Reading - March 7, 2021
- Reduced Lymphatic Reserve in Heart Failure With Preserved Ejection Fraction. Rossitto G, et al. in Journal of the American College of Cardiology, December 15, 2020
- Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin. Russo A, et al. in Nature Immunology, January 21, 2021
- Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination. Yu J, et al. in Nature Medicine, January 4, 2021
- Metformin Preserves β-Cell Compensation in Insulin Secretion and Mass Expansion in Prediabetic Nile Rats. Huang H, et al. in International Journal of Molecular Sciences, January 3, 2021
- Local immune response to food antigens drives meal-induced abdominal pain. Aguilera-Lizarraga J, et al. in Nature, January 13, 2021
Recommended Reading - February 1, 2021
- Fusobacterium nucleatum adheres to Clostridioides difficile via the RadD adhesin to enhance biofilm formation in intestinal mucus. Engevik M, et al. in Gastroenterology, November 20, 2020
- Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. Turner J, et al. in Cell Immunity, October 20, 2020
- Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Minhas P, et al. in Nature, January 20, 2021
- Tetracycline Antibiotics Induce Host-Dependent Disease Tolerance to Infection. Colaco H, et al. in Cell Immunity, October 14, 2020
- Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis. Leimkuhler N, et al. in Cell Stem Cell, December 9, 2020
Recommended Reading - January 3rd, 2021
- Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense. Bosch M, et al. in Science, October 16, 2020
- Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms. Beltra JC, et al. in Immunity, May 19, 2020
- T cells with dysfunctional mitochondria induce multimorbidity and premature senescence. Desdin-Mico G, et al. in Science, June 19, 2020
- Commensal Microbiota Modulation of Natural Resistance to Virus Infection. Stefan K, et al. in Cell, November 25, 2020
- The cancer microbiome atlas: a pan-cancer comparative analysis to distinguish tissue-resident microbiota from contaminants. Dohlman A, et al. in Cell Host & Microbe, December 30, 2020
