Recommended Reading

1. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Wrapp D, et al. in Science, March 13, 2020
2. MAIT cells are imprinted by the microbiota in early life and promote tissue repair. Constantinides, M, et al. in Science, October 25, 2019
3. Optogenetic manipulation of calcium signals in single T cells in vivo. Bohineust A, et al. in Nature, March 2, 2020
4. Live-animal imaging of native haematopoietic stem and progenitor cells. Christodoulou C, et al. in Nature, February 5, 2020
5. Targeting of temperate phages drives loss of type I CRISPR–Cas systems. Rollie C, et al. in Nature, January 22, 2020
6. Combinatorial selection in amoebal hosts drives the evolution of the human pathogen Legionella pneumophila. Park J, et al. in Nature, January 27, 2020
7. Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion. Leone R, et al. in Science, Novemeber 22, 2019
8. Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells. Wang X, et al. in Immunity, February 11, 2020
9. Enhanced immunogenicity of mitochondrial-localized proteins in cancer cells. Prota G, et al. in Cancer Immunology Research, March 12, 2020
10. Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism. Duscha A, et al. in ScienceDirect, March 19, 2020

1. FPR1 is the plague receptor on host immune cells. Osei-Owusu P, et al. in Nature, September 18, 2019
2. Structure elucidation of colibactin and its DNA cross-links. Xue M, et al. in Science, September 6, 2019
3. Ketogenic diet activates protective γδ T cell responses against influenza virus infection. Goldberg EL, et al. in Science, November 11, 2019
4. Staphylococcus aureus toxin suppresses antigen-specific T cell responses. Lee B, et al. in The Journal of Clinical Investigation, December 24, 2019
5. Peripheral T cell expansion predicts tumour infiltration and clinical response. Wu TD, et al. in Nature, February 26, 2020

Bonus Recs!

1. Peritoneal GATA6+ macrophages function as a portal for Staphylococcus aureus dissemination. Jorch S, et al. in The Journal of Clinical Investigation, September 23, 2019
2. Microbial metabolites control the thymic development of mucosal-associated invariant T cells. Legoux F, et al. in Science, October 10, 2019
3. A metagenomic strategy for harnessing the chemical repertoire of the human microbiome. Sugimoto Y, et al. in Science, December 13, 2019
4. Simulation modelling for immunologists. Handel A, et al. in Nature, December 5, 2019
5. Improved protein structure prediction using potentials from deep learning. Senior A W, et al. in Nature, January 15, 2020

1. Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus. Kim S, et al. in Nature, August 21, 2019
2. Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis. Dai J, et al. in Journal of Experimental Medicine, September 23, 2019
3. Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche. Lewin G, et al. in Cell Press, September 24, 2019
4. Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation. Nagashima H, et al. in Science Direct, October 15, 2019
5. Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens. Carfrae L, et al. in Nature, October 28, 2019

1. Long-Distance Cooperative and Antagonistic RNA Polymerase Dynamics via DNA Supercoiling. Sangjin Kim, et al. in Cell Press, September 19, 2019
2. TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors. Guerin M, et al. in Nature, September 11, 2019
3. Large-scale identification of pathogen essential genes during coinfection with sympatric and allopatric microbes. Lewin G, et al. in PNAS, September 24, 2019
4. Bulk tissue cell type deconvolution with multi-subject single-cell expression reference. Wang X, et al. in Nature, January 22, 2019
5. Migratory DCs activate TGF-β to precondition naïve CD8+ T cells for tissue-resident memory fate. Mani V, et al. in Science, October 11, 2019

1. Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory. Blelloch R, Poggio M, et al. in Cell Reports, April 4, 2019
2. Viral complementation of immunodeficiency confers protection against enteric pathogens via interferon-λ. Baldridge MT, Ingle H, et al. in Nature, April 1, 2019
3. Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade. Jacquelot N, et al. in Nature, September 3, 2019
4. Stochastic Variation in Expression of the Tricarboxylic Acid Cycle Produces Persister Cells. Zalis E, et al. in American Society for Microbiology, September 17, 2019
5. The evolution of antibiotic resistance: Clinically relevant evolution studies are needed to help fight the spread of antibiotic resistance. Rekdal V, et al in Science, September 13, 2019

1. Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial. Voorwerk L, et al in Nature, May 13, 2019
2. Human Influenza A Virus Hemagglutinin Glycan Evolution Follows a Temporal Pattern to a Glycan Limit. Yewdell JW, Altman MO, et al in American Society for Microbiology, April 1, 2019
3. Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization. Huggins M, et al in Cell Reports, August 13, 2019
4. Altered immunity of laboratory mice in the natural environment is associated with fungal colonization. Yeung F, et al in bioRxiv, August 21, 2019
5. Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism. Rekdal V, et al in Science, June 14, 2019

1. In Vivo Structures of the Helicobacter pylori cag Type IV Secretion System. Chang YW, Jensen G, et al in Cell Reports, April 17, 2019
2. p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells. Ihry R, Kaykas A, et al in Nature Medicine, June 11, 2018
3. Vesicle-Cloaked Virus Clusters Are Optimal Units for Inter-organismal Viral Transmission. Santiana M, Altan-Bonnet N, et al in Cell Host & Microbe, August 8, 2018
4. Unique Patterns and Biogeochemical Relevance of Two-Component Sensing in Marine Bacteria. Held NA, Saito MA, et al in M Systems - ASM, February 5, 2019
5. Neutrophils: New insights and open questions. Ley K, Catz SD, et al in Science Immunology, December 7, 2018

1. The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet. Olson C, Hsiao EY, et al in Cell, June 14, 2018

2. Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity. Kornberg MD, Snyder SH, et al in Science, April 27, 2018

3. Single-cell bioluminescence imaging of deep tissue in freely moving animals. Iwano S, Miyawaki A, et al in Science, February 23, 2018

4. Identification of Near-Pan-neutralizing Antibodies against HIV-1 by Deconvolution of Plasma Humoral Responses. Sajadi MM, DeVico AL, et al in Cell, June 14, 2018

5. Septal secretion of protein A in Staphylococcus aureus requires SecA and lipoteichoic acid synthesis. Yu W, Schneewind O, et al in eLIFE, May 14, 2018

1. Disruption of staphylococcal aggregation protects against lethal lung injury. Hook J, Bhattacharya J, et al in The Journal of Clinical Investigation, February 12, 2018

2. Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles. Kayama H, Takeda K, et al in PNAS, August 14, 2018

3. Precision editing of the gut microbiota ameliorates colitis. Zhu W, Winter SE, et al in Nature, January 11, 2018

4. Dietary Fiber Confers Protection against Flu by Shaping Ly6c− Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism. Trompette A, Marsland BJ, et al in Cell Immunity, May 15, 2018

5. Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination. Burnett D, Goodnow CC, et al in Science, April 13, 2018

1. Salt-responsive gut commensal modulates Th17 axis and disease. Wilck N, Müller DN, et al in Nature, November 15, 2017
2. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Routy B, Zitvogel L, et al in Science, November 2, 2017
3. Redox-Sensing Under Hypochlorite Stress and Infection Conditions by the Rrf2-Family Repressor HypR in Staphylococcus aureus. Van Loi V, Antelmann H, et al in Antioxidants & Redox Signaling, September 1, 2018
4. Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses. Iyer s, Blumberg RS, et al in Cell, May 17, 2018
5. Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis. Cochain C, Zernecke A, et al in Circulation Research, June 8, 2018