Recommended Reading

1. Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes. Friebel, et al. in Cell, June 25, 2020
2. A probiotic yeast-based immunotherapy against Clostridioides difficile infection. Chen K, et al. in Science Translational Medicine, October 28, 2020
3. Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro. Christensen D, et al. in Science, October 9, 2020
4. Fgr Kinase is required for proinflammatory macrophage activation during diet-induced obesity. Acin-Perez R, et al. in Nature Metabolism, September 17, 2020
5. Highly multiplexed spatial mapping of microbial communities. Shi H, et al. in Nature, December 2, 2020

1. Interpersonal Gut Microbiome Variation Drives Susceptibility and Resistance to Cholera Infection. Alavi S, et al. in Cell, June 25, 2020
2. Immunogenomic Landscape of Hematological Malignancies. Dufva O, et al. in Cancer Cell, July 9, 2020
3. Programmable multistage drug delivery to lymph nodes. Schudel A, et al. in Nature Nanotechnology, June 10, 2020
4. Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes. Zakharov P, et al. in Journal of Experimental Medicine, April 6, 2020
5. Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans. Mateus J, et al. in Science, October 2, 2020

1. Dendritic cell–derived hepcidin sequesters iron from the microbiota to promote mucosal healing. Bessman N, et al. in Science, April 10, 2020
2. Unsupervised machine learning reveals risk stratifying glioblastoma tumor cells. Leelatian N, et al. in eLife, June 23, 2020
3. Glycogen metabolism regulates macrophage-mediated acute inflammatory responses. Ma J, et al. in Nature Communications, April 14, 2020
4. Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals. Grifoni A, et al. in Cell, June 25, 2020
5. Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes. Edner N M, et al. in Nature Immunology, August 3, 2020

1. The stepwise assembly of the neonatal virome is modulated by breastfeeding. Liang G, et al. in Nature, May 15, 2020
2. Association between supratentorial pediatric high-grade gliomas involved with the subventricular zone and decreased survival: a multi-institutional retrospective study. Mistry A, et al. in Journal of Nuerosurgery, May 22, 2020
3. Cardiovascular effects of glucagon-like peptide 1 receptor agonists: from mechanistic studies in humans to clinical outcomes. Heuvelman V, et al. in Cardiovascular Research, April 1, 2020
4. The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides. Wan X, et al. in Nature Immunology, March 9, 2020
5. Bacterial polyphosphates interfere with the innate host defense to infection. Roewe J, et al. in Nature Communications, August 12, 2020

1. A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii. Luna B, et al. in Nature Microbiology, June 8, 2020
2. SARS-CoV-2 infection protects against rechallenge in rhesus macaques. Chandrashekar A, et al. in Science, May 20, 2020
3. Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation. Sinha S, et al. in Cell Host & Microbe, April 8, 2020
4. The human tumor microbiome is composed of tumor type-specific intracellular bacteria. Nejman D, et al. in Science, May 29, 2020
5. Bcl6 and Blimp1 Reciprocally Regulate ST2 + Treg-cell Development in the Context of Allergic Airway Inflammation. Koh B, et al. in The Journal of Allergy and Clinical Immunology, March 13, 2020

1. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sheahan T, et al. in Science Translational Medicine, April 6, 2020
2. Spatially Distinct Physiology of Bacteroides Fragilis Within the Proximal Colon of Gnotobiotic Mice. Donaldson G, et al. in Nature Microbiology, March 9, 2020
3. Evolution of multifunctionality through a pleiotropic substitution in the innate immune protein S100A9. Harman J, et al. in eLife, April 7, 2020
4. DNA vaccine protection against SARS-CoV-2 in rhesus macaques. Jingyou Y, et al. in Science, May 20, 2020
5. ILC2s Amplify PD-1 Blockade by Activating Tissue-Specific Cancer Immunity. Moral JA, et al. in Nature, February 19, 2020

1. Sex-specific adipose tissue imprinting of regulatory T cells. Vasanthakumar A, et al. in Nature, February 26, 2020
2. Metabolites released from apoptotic cells act as tissue messengers. Medina C, et al. in Nature, March 18, 2020
3. Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation. Zhu J, et al. in Cell Metabolism, November 5, 2019
4. Decoy exosomes provide protection against bacterial toxins. Keller M D, et al. in Nature, March 4, 2020
5. Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity. McGinty J, et al. in Cell Press, March 17, 2020
6. Collective Viral Spread Mediated by Virion Aggregates Promotes the Evolution of Defective Interfering Particles.. Andreu-Moreno, Sanjuan, Rafael in American Society for Microbiology Journal, January 7, 2020
7. JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor. O'Hara BA, et al. in PLOS Pathogens, March 4, 2020
8. Fecal IgA Levels Are Determined by Strain-Level Differences in Bacteroides Ovatus and Are Modifiable by Gut Microbiota Manipulation. Yang C, et al. in Cell Host & Microbe, February 18, 2020
9. Long-term dietary intervention reveals resilience of the gut microbiota despite changes in diet and weight. Fragiadais G, et al. in The American Journal of Clinical Nutrition, March 18, 2020
10. Commensal Bacteria Modulate Immunoglobulin A Binding in Response to Host Nutrition. Huus K, et al. in Cell Host & Microbe, April 13, 2020

1. N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I. Lu M, et al. in Nature, April 5, 2020
2. Targeted selection of HIV-specific antibody mutations by engineering B cell maturation. Saunders K, et al. in Science, December 6, 2019
3. Transcriptomic and epigenetic mechanisms underlying myeloid diversity in the lung. Sajti E, et al. in Nature Immunology, January 20, 2020
4. B cells and tertiary lymphoid structures promote immunotherapy response. Helmink B, et al. in Nature, January 15, 2020
5. c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies. Bernink J, et al. in Nature Immunology, November 13, 2019
6. Structure‐Guided Design of a Group B Streptococcus Type III Synthetic Glycan–Conjugate Vaccine. Oldrini D, et al. in Chemistry Europe, February 14, 2020
7. Antirotavirus IgA seroconversion rates in children who receive concomitant oral poliovirus vaccine: A secondary, pooled analysis of Phase II and III trial data from 33 countries. Baker JM, et al. in PLOS Medicine, December 30, 2019
8. An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products. de Los Reyes J M, et al. in Science, April 22, 2020
9. Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. Pleguezuelos-Manzano C, et al. in Nature, February 27, 2020
10. Antibiotic Degradation by Commensal Microbes Shields Pathogens. Gjonbalaj M, et al. in American Society for Microbiology Journal, January 14, 2020

1. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Wrapp D, et al. in Science, March 13, 2020
2. MAIT cells are imprinted by the microbiota in early life and promote tissue repair. Constantinides, M, et al. in Science, October 25, 2019
3. Optogenetic manipulation of calcium signals in single T cells in vivo. Bohineust A, et al. in Nature, March 2, 2020
4. Live-animal imaging of native haematopoietic stem and progenitor cells. Christodoulou C, et al. in Nature, February 5, 2020
5. Targeting of temperate phages drives loss of type I CRISPR–Cas systems. Rollie C, et al. in Nature, January 22, 2020
6. Combinatorial selection in amoebal hosts drives the evolution of the human pathogen Legionella pneumophila. Park J, et al. in Nature, January 27, 2020
7. Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion. Leone R, et al. in Science, Novemeber 22, 2019
8. Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells. Wang X, et al. in Immunity, February 11, 2020
9. Enhanced immunogenicity of mitochondrial-localized proteins in cancer cells. Prota G, et al. in Cancer Immunology Research, March 12, 2020
10. Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism. Duscha A, et al. in ScienceDirect, March 19, 2020

1. FPR1 is the plague receptor on host immune cells. Osei-Owusu P, et al. in Nature, September 18, 2019
2. Structure elucidation of colibactin and its DNA cross-links. Xue M, et al. in Science, September 6, 2019
3. Ketogenic diet activates protective γδ T cell responses against influenza virus infection. Goldberg EL, et al. in Science, November 11, 2019
4. Staphylococcus aureus toxin suppresses antigen-specific T cell responses. Lee B, et al. in The Journal of Clinical Investigation, December 24, 2019
5. Peripheral T cell expansion predicts tumour infiltration and clinical response. Wu TD, et al. in Nature, February 26, 2020

Bonus Recs!

1. Peritoneal GATA6+ macrophages function as a portal for Staphylococcus aureus dissemination. Jorch S, et al. in The Journal of Clinical Investigation, September 23, 2019
2. Microbial metabolites control the thymic development of mucosal-associated invariant T cells. Legoux F, et al. in Science, October 10, 2019
3. A metagenomic strategy for harnessing the chemical repertoire of the human microbiome. Sugimoto Y, et al. in Science, December 13, 2019
4. Simulation modelling for immunologists. Handel A, et al. in Nature, December 5, 2019
5. Improved protein structure prediction using potentials from deep learning. Senior A W, et al. in Nature, January 15, 2020