The fields of infection biology, immunobiology and inflammation research is varied and ever-expanding. Researchers the world over are making discoveries that contribute greatly to our collective understanding of health and disease. VI4 is committed to providing our members, students, and community resources to aid in knowledge-building in these core VI4 research areas. Please check out our current curated recommended reading list below from scientists across the country!
Recommended Reading - January & February 2024
- Synthetic Glycans Reveal Determinants of Antibody Functional Efficacy against a Fungal Pathogen. Crawford C, et al. in ACS Infectious Diseases, October 19, 2023
- Emapalumab for the treatment of refractory cytokine release syndrome in pediatric patients. Schuelke M, et al. in Blood Advances, September 18, 2023
- Molecular jackhammers eradicate cancer cells by vibronic-driven action. Ayala-Orozco C, et al. in Nature Chemistry, December 19, 2023
- Kupffer cell–like syncytia replenish resident macrophage function in the fibrotic liver. Peiseler M, et al. in Science, September 9, 2023
- A geometry-based approach to make viable-cell counting easy and cheap. Meyer C, et al. in Nature Microbiology, November 22, 2023
Recommended Reading - December 17th, 2023
- Probiotic-guided CAR-T cells for solid tumor targeting. Vincent R, et al. in Science, October 12, 2023
- A Candida auris–specific adhesin, Scf1, governs surface association, colonization, and virulence. Santana D, et al. in Science, September 28, 2023
- E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation. Peruenster M, et al. in Nature Immunology, October 30, 2023
- Selection of a de novo gene that can promote survival of Escherichia coli by modulating protein homeostasis pathways. Idan Frumkin & Michael T. Laub. in Nature Ecology & Evolution, November 9, 2023
- Discovery of antibiotics that selectively kill metabolically dormant bacteria. Zheng E, et al . in PNAS, November 28, 2023
Recommended Reading - May 8th, 2022
- Structure of a bacterial Rhs effector exported by the type VI secretion system. Gunther P, et al. in PLOS Pathogen, January 5, 2022
- Maternal inflammation is hard for offspring to stomach. Zengeler KE, Lukens JR. in Immunity, January 11, 2022
- The vulnerable versatility of Salmonella antibiotic persisters during infection. Hill P, et al. in Cell Host & Microbe, December 8, 2021
- Diverse events have transferred genes for edible seaweed digestion from marine to human gut bacteria. Pudlo N, et al. in Cell Host & Microbe, March 9, 2022
- Mechanistic insights into consumption of the food additive xanthan gum by the human gut microbiota. Ostrowski M, et al. in Nature Microbiology, April 1, 2022
Recommended Reading - March 6th, 2022
- T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma. Lozano A, et al. in Nature Medicine, January 13, 2022
- Bacterial gasdermins reveal an ancient mechanism of cell death. Johnson A, et al. in Science, January 13, 2022
- Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Simpson D, et al. in Immunity, February 8, 2022
- Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite. Park SY, et al. in Cell, January 2, 2022
- A SARS-CoV-2 ferritin nanoparticle vaccine elicits protective immune responses in nonhuman primates. Joyce G, et al. in Science Translational Medicine, December 16, 2021
Recommended Reading - February 6th, 2022
- Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis. Hinrichsen F, et al. in Cell Metabolism, December 7, 2021
- Establishment and characterization of stable, diverse, fecal-derived in vitro microbial communities that model the intestinal microbiota. Aranda-Diaz A, et al. in Cell Host & Microbe, January 19, 2022
- Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells. Kim E, et al. in Immunity, January 11, 2022
- An autoimmune stem-like CD8 T cell population drives type 1 diabetes. Gearty S, et al. in Nature, November 30, 2021
- The UGT2A1/UGT2A2 locus is associated with COVID-19-related loss of smell or taste. Shelton J, et al. in Nature Genetics, January 17, 2022
Recommended Reading - September 27, 2021
- Exercise training improves tumor control by increasing CD8+ T-cell infiltration via CXCR3 signaling and sensitizes breast cancer to immune checkpoint blockade. Fukumura K et al. in Cancer Immunology Research, April 10, 2021
- A microRNA expression and regulatory element activity atlas of the mouse immune system. Brown B et al. in Nature Immunology, June 7, 2021
- Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy. Beziat V, et al. in Cell, July 8, 2021
- Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas. Friedrich M, et al. in Nature Cancer, May 24, 2021
- Bifidobacteria-mediated immune system imprinting early in life. Hendrick B, et al. in Cell, July 22, 2021
Recommended Reading - August 15, 2021
- SorTn-seq: a high-throughput functional genomics approach to discovering regulators of bacterial gene expression. Fineran P et al. in Nature Protocols, August 4, 2021
- Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity. Duffy P et al. in Nature, June 30, 2021
- An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer . Thommen D et al. in Nature Medicine, July 8, 2021
- Introducing the Microbes and Social Equity Working Group: Considering the Microbial Components of Social, Environmental, and Health Justice . Morar n et al. in mSystems, July 27, 2021
- Matrix-trapped viruses can prevent invasion of bacterial biofilms by colonizing cells. Nadell C et al. in eLife, July 9, 2021
Recommended Reading - July 18th, 2021
- Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients. Baruch E, et al. in Science, February 5, 2021
- Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid. Heming M, et al. in Cell Immunity, January 12, 2021
- Human NLRP1 is a sensor for double-stranded RNA. Bauernfried S, et al. in Science, January 29, 2021
- Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression. DChen S, et al. in Nature Cell Biology, January 8, 2021
- A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression. Ostuni R et al. in Cell Immunity, June 14, 2021
Recommended Reading - June 6th, 2021
- The gut microbiota is associated with immune cell dynamics in humans. Schluter J, et al. in Nature, December 1, 2020
- Rapid transcriptional and metabolic adaptation of intestinal microbes to host immune activation. Becattini S, et al. in Cell Host & Microbe, March 10, 2021
- Hyperglycemic Memory of Innate Immune Cells Promotes In Vitro Proinflammatory Responses of Human Monocytes and Murine Macrophages. Thiem K, et al. in The Journal of Immunology, January 11, 2021
- Bacterial-driven inflammation and mutant BRAF expression combine to promote murine colon tumorigenesis that is sensitive to immune checkpoint therapy. DeStefano Shields C, et al. in Cancer Discovery, February 25, 2021
- Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling. Hormaechea-Agulla D, et al. in Cell Stem Cell, March 19, 2021
Recommended Reading - May 2nd, 2021
- Exhausted-like CD8 T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects. Diggins K, et al. in JCI Insight, December 22, 2020
- Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity. Montgomery T, et al. in Proceedings of the National Academy of Sciences, November 3, 2020
- Wisp1 is a circulating factor that stimulates proliferation of adult mouse and human beta cells. Fernandez-Ruiz, et al. in Nature Communications, November 25, 2020
- Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage. Johnnidis J, et al. in Science Immunology, January 15, 2021
- Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets. Gong Y, et al. in Cell Metabolism, January 5, 2021
