Acute Metabolic Influences on the Natriuretic Peptide System in Humans. | Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC)

Arora P, Wu C, Hamid T, Arora G, Agha O, Allen K, Tainsh RE, Hu D, Ryan RA, Domian IJ, Buys ES, Bloch DB, Prabhu SD, Bloch KD, Newton-Cheh C, Wang TJ. Acute Metabolic Influences on the Natriuretic Peptide System in Humans. Journal of the American College of Cardiology. 2016 Feb 23;67(67). 804-12. PMID: 26892417 [PubMed]

Abstract

The cardiac natriuretic peptides (NPs), atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), have central roles in sodium and blood pressure regulation. Extracardiac factors (e.g., obesity and diabetes) influence NP production, potentially altering cardiovascular responses to volume and pressure stress.