Circulating Proneurotensin Concentrations and Cardiovascular Disease Events in the Community: The Framingham Heart Study. | Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC)

Januzzi JL, Lyass A, Liu Y, Gaggin H, Trebnick A, Maisel AS, D'Agostino RB, Wang TJ, Massaro J, Vasan RS. Circulating Proneurotensin Concentrations and Cardiovascular Disease Events in the Community: The Framingham Heart Study. Arteriosclerosis, thrombosis, and vascular biology. 2016 Aug;36(36). 1692-7. PMID: 27312221 [PubMed] PMCID: PMC4965295 NIHMSID: NIHMS793656.

Abstract

Neurotensin is a peptide whose receptor (sortilin receptor 1) is linked to cardiovascular disease (CVD) development. We hypothesized concentrations of proneurotensin (stable profragment of neurotensin) would predict incident cardiovascular events in community-based subjects.