Metabolomics reveals the impact of type 2 diabetes on local muscle and vascular responses to ischemic stress. | Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC)

Beckman JA, Hu JR, Huang S, Farber-Eger E, Wells Q, Wang TJ, Gerszten R, Ferguson J. Metabolomics reveals the impact of type 2 diabetes on local muscle and vascular responses to ischemic stress. Clinical science (London, England : 1979). 2020 Sep 3. PMID: 32880388 [PubMed]

Abstract

Type 2 Diabetes Mellitus (T2DM) reduces exercise capacity, but the mechanisms are incompletely understood. We probed the impact of ischemic stress on skeletal muscle metabolite signatures and T2DM-related vascular dysfunction.