John Jeffrey Carr, MD
My research is focused on developing quantitative imaging based biomarkers that can be used for to predict future disease risk or to support clinical decision making in populations or for personalized medicine applications.
Longitudinal Changes in Pericardial Adiposity and Subclinical Atherosclerosis - R01 HL 098445
Obesity in early life in African American and white adults is a factor in premature heart disease and cardiovascular death. We will leverage an existing study of 5,115 individuals with 25 years of follow-up to make new measurements with CT and echocardiography and determine how fat located in the heart and abdomen changes over 10 years of early adult life and influences subsequent heart disease. We are making novel measures related to the remodeling of the coronary arteries from atherosclerosis.
The Cardiovascular Research Grid (CVRG) Project - R24 HL085343
The CVRG is a national resource providing the capability to store, manage, and analyze data on the structure and function of the cardiovascular system in health and disease. The CVRG Project will develop new tools that will enhance the ability of researchers to explore and analyze their data to understand the cause and treatment of heart disease.
Skeletal Muscle Adiposity in Black Men with High Type 2 Diabetes Risk--TOBAGO
We are obtaining and analyzing 1600 CT scans from men of African origin living on the island of Tobago for coronary artery calcium, aortic artery calcium, abdominal adipose tissue volumes, abdominal muscle volumes and composition, pericardial adipose tissue, and liver attenuation. These data will be combined with clinical variables and genetic data to determine how lifestyle, environmental and genetic factors influence cardiovascular disease and diabetes.
Research Information
Reis JP, Launer LJ, Terry JG, Loria CM, Zeki Al Hazzouri A, Sidney S, Yaffe K, Jacobs DR Jr, Whitlow CT, Zhu N, Carr JJ.Subclinical atherosclerotic calcification and cognitive functioning in middle-aged adults: the CARDIA study. Atherosclerosis. 2013 Nov;231(1):72-7. doi: 10.1016/j.atherosclerosis.2013.08.038. Epub 2013 Sep 10. PubMed PMID: 24125414; PubMed Central PMCID: PMC3828555.
Messier SP, Mihalko SL, Legault C, Miller GD, Nicklas BJ, DeVita P, Beavers DP, Hunter DJ, Lyles MF, Eckstein F, Williamson JD, Carr JJ, Guermazi A, Loeser RF. Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. JAMA. 2013 Sep 25;310(12):1263-73. doi: 10.1001/jama.2013.277669. PubMed PMID: 24065013.
Reis JP, Loria CM, Lewis CE, Powell-Wiley TM, Wei GS, Carr JJ, Terry JG, Liu K. Association between duration of overall and abdominal obesity beginning in young adulthood and coronary artery calcification in middle age. JAMA. 2013 Jul 17;310(3):280-8. doi: 10.1001/jama.2013.7833. PubMed PMID: 23860986.
Carr JJ, Hendel RC, White RD, Patel MR, Wolk MJ, Bettmann MA, Douglas P, Rybicki FJ, Kramer CM, Woodard PK, Shaw LJ, Yucel EK. 2013 appropriate utilization of cardiovascular imaging: a methodology for the development of joint criteria for the appropriate utilization of cardiovascular imaging by the American College of Cardiology Foundation and American College of Radiology. J Am Coll Cardiol. 2013 May 28;61(21):2199-206. doi: 10.1016/j.jacc.2013.02.010. Epub 2013 Mar 5. Review. PubMed PMID: 23500292.
Barr RG, Bluemke DA, Ahmed FS, Carr JJ, Enright PL, Hoffman EA, Jiang R, Kawut SM, Kronmal RA, Lima JA, Shahar E, Smith LJ, Watson KE. Percent emphysema, airflow obstruction, and impaired left ventricular filling. N Engl J Med. 2010 Jan 21;362(3):217-27. doi: 10.1056/NEJMoa0808836. PubMed PMID: 20089972; PubMed Central PMCID: PMC2887729.