Charles Caskey, Ph.D.
Charles Caskey’s research focuses on diagnostic and therapeutic uses of ultrasound, particularly in image-guided therapy applications. He received his doctoral degree for studies about the bioeffects of ultrasound during microbubble-enhanced drug delivery under Dr. Katherine Ferrara at the University of California at Davis in 2008, and in 2018, he received the Fred Lizzi Early Career Award from the International Society of Therapeutic ultrasound. He currently leads the Laboratory of Acoustic Therapy and Imaging at the Vanderbilt University Institute of Imaging Science where his laboratory focuses on developing new uses for ultrasound, spanning neuromodulation, drug delivery, and functional imaging.
Research Information
Manuel TJ, Kusunose J, Zhan X, Lv X, Kang E, Yang A, Xiang Z, Caskey CF. Ultrasound neuromodulation depends on pulse repetition frequency and can modulate inhibitory effects of TTX. Scientific Reports. 2020 Sep 18;10(1):15347..
Phipps, M.A., Jonathan, S.V., Yang, P.F., Chaplin, V., Chen, L.M., Grissom, W.A. and Caskey, C.F., 2019. Considerations for ultrasound exposure during transcranial MR acoustic radiation force imaging. Scientific reports, 9(1), p.16235.
Yang PF, Phipps MA, Newton AT, Chaplin V, Gore JC, Caskey CF, Chen LM. Neuromodulation of sensory networks in monkey brain by focused ultrasound with MRI guidance and detection. Scientific reports. 2018 May 22;8(1):7993.
Manuel TJ, Sigona MK, Phipps MA, Kusunose J, Luo H, Yang PF, Newton AT, Gore JC, Grissom W, Chen LM, Caskey CF. Small volume blood-brain barrier opening in macaques with a 1 MHz ultrasound phased array. Journal of Controlled Release. 2023 Nov 1;363:707-20.