Daniel Gochberg, Ph.D. | Vanderbilt University Institute of Imaging Science

Our research focuses on the development, characterization, and application of MRI methods for quantifying tissue parameters, most importantly exchange between tissue water and macromolecules and metabolites. Such methods have their greatest application in imaging multiple sclerosis (MS).

We are currently working on developing and applying methods for measuring spin exchange, including developing new methods to detect tissue exchange sites (such as amides) using chemical exchange saturation transfer (CEST) and T1p. Also, we are applying quantitative magnetization transfer (qMT) methods to a rat model of multiple sclerosis in order to determine the method's sensitivity to myelin. This work may result in improved methods for research and clinical imaging.

Research Information

C.L. Lankford, E.A. Louie, Z. Zu, M.D. Does, D.F. Gochberg. A hybrid numeric-analytic solution for pulsed CEST. NMR in Biomedicine, 35(1), e4610, 2022. http://doi.org/10.1002/nbm.4610

Y. Zhao, Z. Zu, J. Xu, J.C. Gore, M.D. Does, J. Li, D.F. Gochberg. Mapping pH using stimulated echoes formed via chemical exchange. Magn. Reson. Imaging, 92: 100-107, 2022.

Z. Zu, E.C. Lin, E.A. Louie, X. Jiang, C.L. Lankford, B. Damon, M.D. Does, J.C. Gore, D.F. Gochberg. Chemical exchange rotation transfer imaging of phosphocreatine in muscle. NMR in Biomedicine, 34(2), e4437, 2021. http://doi.org/10.1002/nbm.4437

Z. Zu, E.C. Lin, E.A. Louie, J. Xu, H. Li, J. Xie, C.L. Lankford, E.Y. Chekmenev, S.D. Swanson, M.D. Does, J.C. Gore, D.F. Gochberg. Relayed nuclear Overhauser enhancement sensitivity to membrane Cho phospholipids. Magn. Reson. Med., 84(4):1961-1976, 2020: http://doi.org/10.1002/mrm.28258

Z. Zu, K. Li, V.A. Janve, M.D. Does, D.F. Gochberg. Optimizing pulsed-chemical exchange saturation transfer imaging sequences; Magnetic Resonance in Medicine, 66(4): 1100-1108, 2011;