Our research in general focuses on developing statistical methods and computational tools for genetics and genomics studies, and applying these tools to identify genetic factors associated with diseases. Our current work focuses on developing methods for inferring genetic variants including de novo mutations in family data and genomic aberrations in cancer genomes from next-generation sequencing data. Our applied work utilizes targeted and whole genome sequencing to identify rare genetic variants associated with psychiatric disorders, and to investigate somatic aberrations in tumors to understand the spectrum of mutations and their implication in personalized treatment of cancer.