Deep brain stimulation in early-stage Parkinson’s disease
More than one million Americans are living with Parkinson’s disease, a progressive neurodegenerative movement disorder characterized by loss of dopaminergic neurons in the substantia nigra. Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an approved adjunctive therapy for mid- and advanced stage Parkinson’s disease that improves motor symptoms, quality of life, and activities of daily living while also reducing medication burden and associated complications. Vanderbilt University Medical Center completed the only prospective, randomized clinical trial testing DBS in very early stage Parkinson’s disease. Our ongoing line of research aims to investigate DBS in early stage Parkinson’s disease to better understand if this treatment may slow the progression of the disease.
2023
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Hacker ML, Tramontana MG, Pazira K, Meystedt JC, Turchan M, Harper KA, Fan R, Ye F, Davis TL, Konrad PE, Charles D. Long-term neuropsychological outcomes of deep brain stimulation in early-stage Parkinson's disease. Parkinsonism & related disorders. 2023 Aug;113(113). 105479 p.
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Hacker ML, Rajamani N, Neudorfer C, Hollunder B, Oxenford S, Li N, Sternberg AL, Davis TL, Konrad PE, Horn A, Charles D. Connectivity Profile for Subthalamic Nucleus Deep Brain Stimulation in Early Stage Parkinson Disease. Annals of neurology. 2023 Aug;94(94). 271-284.
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Hacker ML, Meystedt JC, Turchan M, Cannard KR, Harper K, Fan R, Ye F, Davis TL, Konrad PE, Charles D. Eleven-Year Outcomes of Deep Brain Stimulation in Early-Stage Parkinson Disease. Neuromodulation : journal of the International Neuromodulation Society. 2023 Feb;26(26). 451-458. NIHMSID: NIHMS1844085.
2022
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Sortwell CE, Hacker ML, Fischer DL, Konrad PE, Davis TL, Neimat JS, Wang L, Song Y, Mattingly ZR, Cole-Strauss A, Lipton JW, Charles PD. BDNF rs6265 Genotype Influences Outcomes of Pharmacotherapy and Subthalamic Nucleus Deep Brain Stimulation in Early-Stage Parkinson's Disease. Neuromodulation : journal of the International Neuromodulation Society. 2022 Aug;25(25). 846-853. NIHMSID: NIHMS1721599.
2021
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Hacker M, Cannard G, Turchan M, Meystedt J, Davis T, Phibbs F, Hedera P, Konrad P, Charles D. Early subthalamic nucleus deep brain stimulation in Parkinson's disease reduces long-term medication costs. Clinical neurology and neurosurgery. 2021 Oct 8;210(210). 106976 p.
2020
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Fischer DL, Auinger P, Goudreau JL, Cole-Strauss A, Kieburtz K, Elm JJ, Hacker ML, Charles PD, Lipton JW, Pickut BA, Sortwell CE. BDNF rs6265 Variant Alters Outcomes with Levodopa in Early-Stage Parkinson's Disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2020 Nov 19.
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Hacker ML, Turchan M, Heusinkveld LE, Currie AD, Millan SH, Molinari AL, Konrad PE, Davis TL, Phibbs FT, Hedera P, Cannard KR, Wang L, Charles D. Deep Brain Stimulation in Early-Stage Parkinson's Disease: Five Year Outcomes. Neurology. 2020 Jun 29.
2018
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Hacker ML, DeLong MR, Turchan M, Heusinkveld LE, Ostrem JL, Molinari AL, Currie AD, Konrad PE, Davis TL, Phibbs FT, Hedera P, Cannard KR, Drye LT, Sternberg AL, Shade DM, Tonascia J, Charles D. Effects of deep brain stimulation on rest tremor progression in early stage Parkinson disease. Neurology. 2018 Dec 31;91(91). e463-e471.
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Heusinkveld LE, Hacker ML, Turchan M, Davis TL, Charles D. Impact of Tremor on Patients With Early Stage Parkinson's Disease. Frontiers in neurology. 9(9). 628 p.
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Grace Cannard K, Hacker ML, Molinari A, Heusinkveld LE, Currie AD, Charles D. Recruitment and Retention in Clinical Trials of Deep Brain Stimulation in Early-Stage Parkinson's Disease: Past Experiences and Future Considerations. Journal of Parkinson's disease. 8(8). 421-428.
2017
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Heusinkveld L, Hacker M, Turchan M, Bollig M, Tamargo C, Fisher W, McLaughlin L, Martig A, Charles D. Patient Perspectives on Deep Brain Stimulation Clinical Research in Early Stage Parkinson's Disease. Journal of Parkinson's disease. 7(7). 89-94.
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Millan SH, Hacker ML, Turchan M, Molinari AL, Currie AD, Charles D. Subthalamic Nucleus Deep Brain Stimulation in Early Stage Parkinson's Disease Is Not Associated with Increased Body Mass Index. Parkinson's disease. 2017(2017). 7163801 p.
2016
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Hacker ML, Currie AD, Molinari AL, Turchan M, Millan SM, Heusinkveld LE, Roach J, Konrad PE, Davis TL, Neimat JS, Phibbs FT, Hedera P, Byrne DW, Charles D. Subthalamic Nucleus Deep Brain Stimulation May Reduce Medication Costs in Early Stage Parkinson's Disease. Journal of Parkinson's disease. 6(6). 125-31.
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Hacker M, Charles D, Finder S. Deep brain stimulation in early stage Parkinson's disease may reduce the relative risk of symptom worsening. Parkinsonism & related disorders. 2016 Jan;22(22). 112-3.
2015
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Hacker ML, Tonascia J, Turchan M, Currie A, Heusinkveld L, Konrad PE, Davis TL, Neimat JS, Phibbs FT, Hedera P, Wang L, Shi Y, Shade DM, Sternberg AL, Drye LT, Charles D. Deep brain stimulation may reduce the relative risk of clinically important worsening in early stage Parkinson's disease. Parkinsonism & related disorders. 2015 Oct;21(21). 1177-83.
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Charles D, Konrad PE, Davis TL, Neimat JS, Hacker ML, Finder SG. Deep brain stimulation in early stage Parkinson's disease. Parkinsonism & related disorders. 2015 Mar;21(21). 347-8.
2012
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Charles PD, Dolhun RM, Gill CE, Davis TL, Bliton MJ, Tramontana MG, Salomon RM, Wang L, Hedera P, Phibbs FT, Neimat JS, Konrad PE. Deep brain stimulation in early Parkinson's disease: enrollment experience from a pilot trial. Parkinsonism & related disorders. 2012 Mar;18(18). 268-73. NIHMSID: NIHMS340519.
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Kahn E, D'Haese PF, Dawant B, Allen L, Kao C, Charles PD, Konrad P. Deep brain stimulation in early stage Parkinson's disease: operative experience from a prospective randomised clinical trial. Journal of neurology, neurosurgery, and psychiatry. 2012 Feb;83(83). 164-70. NIHMSID: NIHMS477546.
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Charles D, Tolleson C, Davis TL, Gill CE, Molinari AL, Bliton MJ, Tramontana MG, Salomon RM, Kao C, Wang L, Hedera P, Phibbs FT, Neimat JS, Konrad PE. Pilot study assessing the feasibility of applying bilateral subthalamic nucleus deep brain stimulation in very early stage Parkinson's disease: study design and rationale. Journal of Parkinson's disease. 2(2). 215-23. NIHMSID: NIHMS600758.