Location-specific epigenetic regulation of the metallothionein 3 gene in esophageal adenocarcinomas. | Cooperative Human Tissue Network Western Division

Peng D, Hu TL, Jiang A, Washington MK, Moskaluk CA, Schneider-Stock R, El-Rifai W. Location-specific epigenetic regulation of the metallothionein 3 gene in esophageal adenocarcinomas. PloS one. 6(6). e22009. PMID: 21818286 [PubMed] PMCID: PMC3139601

Abstract

Metallothionein 3 (MT3) maintains intracellular metal homeostasis and protects against reactive oxygen species (ROS)-induced DNA damage. In this study, we investigated the epigenetic alterations and gene expression of the MT3 gene in esophageal adenocarcinomas (EACs).