Prevention of Stroke in Children with Sickle Cell Anemia in Nigeria: A task shifting community hospital approach
Stroke is a devastating complication of sickle cell anemia (SCA) occurring in approximately 11% of children affected with the disease in resource-limited countries, compared to 1% in high-income countries. Nigeria bears 50% of childhood SCA's global burden, and stroke is a frequent complication leading to increased death and disability.
Moderate fixed‐dose hydroxyurea for primary prevention of strokes in Nigerian children with sickle cell disease: Final results of the SPIN trial
Sickle cell disease (SCD), an inherited blood disorder, is prevalent throughout sub-Saharan Africa. Approximately 240,000 children are born with SCD each year across the continent of Africa, and up to 70% of those infants born with sickle cell disease die before the age of five.