The study of acute leukemia has yielded the first demonstration of a genetic alteration in human cancer, the identification of the first oncogene in humans, the first demonstration of impairment of apoptosis in tumorigenesis, and the first demonstration of targeted therapeutics in cancer. Acute leukemia is characterized by chromosomal translocations, which affect master regulatory genes.
At Hiebert Laboratory, we focus on Acute leukemia, tumor suppressors, cell cycle, transcriptional repression, co-repressors,Cell cycle,Chromatin,Chromosome,Gene regulation,Malignancy,Mouse,Signal transduction,Stem cells,Transcription,Transcription factor.
