Mitochondrial DNA haplogroups and weight gain following switch to integrase strand transfer inhibitor-based antiretroviral therapy.

Erlandson KM, Wu K, Lake JE, Samuels DC, Bares SH, Tassiopoulos K, Koethe JR, Brown TT, Leonard M, Benson CA, Haas DW, Hulgan T. Mitochondrial DNA haplogroups and weight gain following switch to integrase strand transfer inhibitor-based antiretroviral therapy. AIDS (London, England). 2021 Dec 1;35(35). 439-445. PMID: 33252493 [PubMed] PMCID: PMC7951953 NIHMSID: NIHMS1656549.

Abstract

Integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) has been associated with excess weight gain in some adults, which may be influenced by genetic factors. We assessed mitochondrial DNA (mtDNA) haplogroups and weight gain following switch to INSTI-based ART.