2015
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Schulte ML, Dawson ES, Saleh SA, Cuthbertson ML, Manning HC. 2-Substituted Nγ-glutamylanilides as novel probes of ASCT2 with improved potency. Bioorganic & medicinal chemistry letters. 2015 Jan 1;25(25). 113-6.
2014
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Comerford SA, Huang Z, Du X, Wang Y, Cai L, Witkiewicz AK, Walters H, Tantawy MN, Fu A, Manning HC, Horton JD, Hammer RE, McKnight SL, Tu BP. Acetate dependence of tumors. Cell. 2014 Dec 18;159(159). 1591-602. NIHMSID: NIHMS642906.
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Cheung Y, Nickels ML, McKinley ET, Buck JR, Manning HC. High-yielding, automated production of 3'-deoxy-3'-[(18)F]fluorothymidine using a modified Bioscan Coincidence FDG reaction module. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 2014 Dec 15;97C(97C). 47-51.
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Tang D, Nickels ML, Tantawy MN, Buck JR, Manning HC. Preclinical imaging evaluation of novel TSPO-PET ligand 2-(5,7-Diethyl-2-(4-(2-[(18)F]fluoroethoxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide ([ (18)F]VUIIS1008) in glioma. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2014 Dec;16(16). 813-20.
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Han W, Zaynagetdinov R, Yull FE, Polosukhin VV, Gleaves LA, Tanjore H, Young LR, Peterson TE, Manning HC, Prince LS, Blackwell TS. Molecular Imaging of Folate Receptor Beta Positive Macrophages During Acute Lung Inflammation. American journal of respiratory cell and molecular biology. 2014 Nov 6.
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Cheung YY, Nickels ML, Tang D, Buck JR, Manning HC. Facile synthesis of SSR180575 and discovery of 7-chloro-N,N,5-trimethyl-4-oxo-3(6-[(18)F]fluoropyridin-2-yl)-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, a potent pyridazinoindole ligand for PET imaging of TSPO in cancer. Bioorganic & medicinal chemistry letters. 2014 Sep 15;24(24). 4466-71. NIHMSID: NIHMS620016.
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Whisenant JG, McIntyre JO, Peterson TE, Kang H, Sánchez V, Manning HC, Arteaga CL, Yankeelov TE. Utility of [(18) F]FLT-PET to Assess Treatment Response in Trastuzumab-Resistant and Trastuzumab-Sensitive HER2-Overexpressing Human Breast Cancer Xenografts. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2014 Jul 18.
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Powell AE, Vlacich G, Zhao ZY, McKinley ET, Washington MK, Manning HC, Coffey RJ. Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposis. American journal of physiology. Gastrointestinal and liver physiology. 2014 Jul 1;307(307). G16-23.
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Perrone MG, Malerba P, Uddin MJ, Vitale P, Panella A, Crews BC, Daniel CK, Ghebreselasie K, Nickels M, Tantawy MN, Manning HC, Marnett LJ, Scilimati A. PET radiotracer [¹⁸F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation. European journal of medicinal chemistry. 2014 Jun 10;80(80). 562-8.
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Hight MR, Cheung YY, Nickels ML, Dawson ES, Zhao P, Saleh S, Buck JR, Tang D, Washington MK, Coffey RJ, Manning HC. A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells. Clinical cancer research : an official journal of the American Association for Cancer Research. 2014 Apr 15;20(20). 2126-35. NIHMSID: NIHMS571532.
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McKinley ET, Zhao P, Coffey RJ, Washington MK, Manning HC. 3'-Deoxy-3'-[18F]-Fluorothymidine PET imaging reflects PI3K-mTOR-mediated pro-survival response to targeted therapy in colorectal cancer. PloS one. 9(9). e108193.
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Uddin MI, Buck JR, Schulte ML, Tang D, Saleh SA, Cheung YY, Harp J, Manning HC. Microwave-assisted, one-pot reaction of 7-azaindoles and aldehydes: a facile route to novel di-7-azaindolylmethanes. Tetrahedron letters. 2014 Jan 1;55(55). NIHMSID: NIHMS538764.
2013
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Katsha A, Soutto M, Sehdev V, Peng D, Washington MK, Piazuelo MB, Tantawy MN, Manning HC, Lu P, Shyr Y, Ecsedy J, Belkhiri A, El-Rifai W. Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia. Gastroenterology. 2013 Dec;145(145). 1312-22.e1-8. NIHMSID: NIHMS521570.
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Walsh AJ, Cook RS, Manning HC, Hicks DJ, Lafontant A, Arteaga CL, Skala MC. Optical metabolic imaging identifies glycolytic levels, subtypes, and early-treatment response in breast cancer. Cancer research. 2013 Oct 15;73(73). 6164-74. NIHMSID: NIHMS515760.
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Xie J, Wang C, Virostko J, Manning HC, Pham W, Bauer J, Gore JC. A novel reporter system for molecular imaging and high-throughput screening of anticancer drugs. Chembiochem : a European journal of chemical biology. 2013 Aug 19;14(14). 1494-503. NIHMSID: NIHMS520824.
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Tang D, McKinley ET, Hight MR, Uddin MI, Harp JM, Fu A, Nickels ML, Buck JR, Manning HC. Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imaging. Journal of medicinal chemistry. 2013 Apr 25;56(56). 3429-33. NIHMSID: NIHMS464016.
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McKinley ET, Smith RA, Zhao P, Fu A, Saleh SA, Uddin MI, Washington MK, Coffey RJ, Manning HC. 3'-Deoxy-3'-18F-fluorothymidine PET predicts response to (V600E)BRAF-targeted therapy in preclinical models of colorectal cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2013 Mar;54(54). 424-30. NIHMSID: NIHMS459295.
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McKinley ET, Ayers GD, Smith RA, Saleh SA, Zhao P, Washington MK, Coffey RJ, Manning HC. Limits of [18F]-FLT PET as a biomarker of proliferation in oncology. PloS one. 8(8). e58938.
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Thompson MM, Manning HC, Ellacott KL. Translocator protein 18 kDa (TSPO) is regulated in white and brown adipose tissue by obesity. PloS one. 8(8). e79980.
2012
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McKinley ET, Smith RA, Tanksley JP, Washington MK, Walker R, Coffey RJ, Manning HC. [18F]FLT-PET to predict pharmacodynamic and clinical response to cetuximab therapy in Ménétrier's disease. Annals of nuclear medicine. 2012 Nov;26(26). 757-63. NIHMSID: NIHMS432186.
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Yankeelov TE, Peterson TE, Abramson RG, Izquierdo-Garcia D, Garcia-Izquierdo D, Arlinghaus LR, Li X, Atuegwu NC, Catana C, Manning HC, Fayad ZA, Gore JC. Simultaneous PET-MRI in oncology: a solution looking for a problem? Magnetic resonance imaging. 2012 Nov;30(30). 1342-56. NIHMSID: NIHMS387000.
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Wang C, Xie J, Guo J, Manning HC, Gore JC, Guo N. Evaluation of CD44 and CD133 as cancer stem cell markers for colorectal cancer. Oncology reports. 2012 Oct;28(28). 1301-8.
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Buck JR, Saleh S, Uddin MI, Manning HC. Rapid, Microwave-Assisted Organic Synthesis of Selective (V600E)BRAF Inhibitors for Preclinical Cancer Research. Tetrahedron letters. 2012 Aug 8;53(53). 4161-4165. NIHMSID: NIHMS384634.
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Wyatt SK, Manning HC, Bai M, Ehtesham M, Mapara KY, Thompson RC, Bornhop DJ. Preclinical molecular imaging of the translocator protein (TSPO) in a metastases model based on breast cancer xenografts propagated in the murine brain. Current molecular medicine. 2012 May;12(12). 458-66.
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Tang D, Hight MR, McKinley ET, Fu A, Buck JR, Smith RA, Tantawy MN, Peterson TE, Colvin DC, Ansari MS, Nickels M, Manning HC. Quantitative preclinical imaging of TSPO expression in glioma using N,N-diethyl-2-(2-(4-(2-18F-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2012 Feb;53(53). 287-94. NIHMSID: NIHMS387929.
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Myers MV, Manning HC, Coffey RJ, Liebler DC. Protein expression signatures for inhibition of epidermal growth factor receptor-mediated signaling. Molecular & cellular proteomics : MCP. 2012 Feb;11(11). M111.015222.
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Xu J, Li K, Smith RA, Waterton JC, Zhao P, Chen H, Does MD, Manning HC, Gore JC. Characterizing tumor response to chemotherapy at various length scales using temporal diffusion spectroscopy. PloS one. 7(7). e41714.
2011
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Miller TW, Balko JM, Fox EM, Ghazoui Z, Dunbier A, Anderson H, Dowsett M, Jiang A, Smith RA, Maira SM, Manning HC, González-Angulo AM, Mills GB, Higham C, Chanthaphaychith S, Kuba MG, Miller WR, Shyr Y, Arteaga CL. ERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer. Cancer discovery. 2011 Sep;1(1). 338-51. NIHMSID: NIHMS323247.
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Gore JC, Manning HC, Quarles CC, Waddell KW, Yankeelov TE. Magnetic resonance in the era of molecular imaging of cancer. Magnetic resonance imaging. 2011 Jun;29(29). 587-600. NIHMSID: NIHMS292591.
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McKinley ET, Bugaj JE, Zhao P, Guleryuz S, Mantis C, Gokhale PC, Wild R, Manning HC. 18FDG-PET predicts pharmacodynamic response to OSI-906, a dual IGF-1R/IR inhibitor, in preclinical mouse models of lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2011 May 15;17(17). 3332-40. NIHMSID: NIHMS267246.
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Guo N, Xie J, Manning HC, Deane NG, Ansari MS, Coffey RJ, Gore J, Price RR, Baldwin RM, McIntyre JO. A novel in vitro assay to assess phosphorylation of 3'-[(18)F]fluoro-3'-deoxythymidine. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2011 Apr;13(13). 257-64. NIHMSID: NIHMS629772.
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Buck JR, McKinley ET, Hight MR, Fu A, Tang D, Smith RA, Tantawy MN, Peterson TE, Colvin D, Ansari MS, Baldwin RM, Zhao P, Guleryuz S, Manning HC. Quantitative, preclinical PET of translocator protein expression in glioma using 18F-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2011 Jan;52(52). 107-14. NIHMSID: NIHMS265492.
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Smith RA, Guleryuz S, Manning HC. Molecular imaging metrics to evaluate response to preclinical therapeutic regimens. Frontiers in bioscience (Landmark edition). 16(16). 393-410. NIHMSID: NIHMS220879.
2010
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Tang D, Buck JR, Hight MR, Manning HC. Microwave-assisted Organic Synthesis of a High-affinity Pyrazolo-pyrimidinyl TSPO Ligand. Tetrahedron letters. 2010 Sep 1;51(51). 4595-4598. NIHMSID: NIHMS217874.
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Ayers GD, McKinley ET, Zhao P, Fritz JM, Metry RE, Deal BC, Adlerz KM, Coffey RJ, Manning HC. Volume of preclinical xenograft tumors is more accurately assessed by ultrasound imaging than manual caliper measurements. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. 2010 Jun;29(29). 891-901. NIHMSID: NIHMS219894.
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Wyatt SK, Manning HC, Bai M, Bailey SN, Gallant P, Ma G, McIntosh L, Bornhop DJ. Molecular imaging of the translocator protein (TSPO) in a pre-clinical model of breast cancer. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2010 Jun;12(12). 349-58.
2009
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Miller TW, Forbes JT, Shah C, Wyatt SK, Manning HC, Olivares MG, Sanchez V, Dugger TC, De Matos Granja N, Narasanna A, Cook RS, Kennedy JP, Lindsley CW, Arteaga CL. Inhibition of mammalian target of rapamycin is required for optimal antitumor effect of HER2 inhibitors against HER2-overexpressing cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 Dec 1;15(15). 7266-76. NIHMSID: NIHMS151083.
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Yankeelov TE, Avison MJ, Damon BM, Manning HC, Peterson TE, Gore JC. Frontiers of Biomedical Imaging Science 2009: workshop report and research opportunities. Cancer research. 2009 Oct 15;69(69). 7902-4. NIHMSID: NIHMS141005.
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Peterson TE, Manning HC. Molecular imaging: 18F-FDG PET and a whole lot more. Journal of nuclear medicine technology. 2009 Sep;37(37). 151-61. NIHMSID: NIHMS173453.
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Shah C, Miller TW, Wyatt SK, McKinley ET, Olivares MG, Sanchez V, Nolting DD, Buck JR, Zhao P, Ansari MS, Baldwin RM, Gore JC, Schiff R, Arteaga CL, Manning HC. Imaging biomarkers predict response to anti-HER2 (ErbB2) therapy in preclinical models of breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 Jul 15;15(15). 4712-21. NIHMSID: NIHMS170720.
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Manning HC, Shay SD, Mericle RA. Multispectral molecular imaging of capillary endothelium to facilitate preoperative endovascular brain mapping. Journal of neurosurgery. 2009 May;110(110). 975-80. NIHMSID: NIHMS170729.
2008
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Manning HC, Merchant NB, Foutch AC, Virostko JM, Wyatt SK, Shah C, McKinley ET, Xie J, Mutic NJ, Washington MK, LaFleur B, Tantawy MN, Peterson TE, Ansari MS, Baldwin RM, Rothenberg ML, Bornhop DJ, Gore JC, Coffey RJ. Molecular imaging of therapeutic response to epidermal growth factor receptor blockade in colorectal cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2008 Nov 15;14(14). 7413-22. NIHMSID: NIHMS96162.
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Manning HC, Lander A, McKinley E, Mutic NJ. Accelerating the development of novel molecular imaging probes: a role for high-throughput screening. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2008 Sep;49(49). 1401-4. NIHMSID: NIHMS74109.
2007
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Deane NG, Manning HC, Foutch AC, Washington MK, Aronow BJ, Aronow BA, Bornhop DJ, Coffey RJ. Targeted imaging of colonic tumors in smad3-/- mice discriminates cancer and inflammation. Molecular cancer research : MCR. 2007 Apr;5(5). 341-9.
2002
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Manning HC, Goebel T, Marx JN, Bornhop DJ. Facile, efficient conjugation of a trifunctional lanthanide chelate to a peripheral benzodiazepine receptor ligand. Organic letters. 2002 Apr 4;4(4). 1075-8.
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Virostko J, Xie J, Hallahan DE, Arteaga CL, Gore JC, Manning HC. A molecular imaging paradigm to rapidly profile response to angiogenesis-directed therapy in small animals. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 11(11). 204-12. NIHMSID: NIHMS96161.
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Hight MR, Nolting DD, McKinley ET, Lander AD, Wyatt SK, Gonyea M, Zhao P, Manning HC. Multispectral fluorescence imaging to assess pH in biological specimens. Journal of biomedical optics. 16(16). 016007 p.
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Manning HC, Smith SM, Sexton M, Haviland S, Bai M, Cederquist K, Stella N, Bornhop DJ. A peripheral benzodiazepine receptor targeted agent for in vitro imaging and screening. Bioconjugate chemistry. 17(17). 735-40.