Machine Learning Model Predictors of Intrapleural tPA and DNase Failure in Pleural Infection: A Multicenter Study.

Khemasuwan D, Wilshire C, Reddy C, Gilbert C, Gordon J, Balwan A, Sanchez TM, Bixby B, Sorensen JS, Shojaee S. Machine Learning Model Predictors of Intrapleural tPA and DNase Failure in Pleural Infection: A Multicenter Study. Annals of the American Thoracic Society. 2024 Oct 29. PMID: 39471322 [PubMed]

Abstract

Intrapleural enzyme therapy (IET) with tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) has been shown to reduce the need for surgical intervention for complicated parapneumonic effusion/empyema (CPPE/empyema). Failure of IET may lead to delayed care, and increased length of stay.