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Hellwege JN, Stallings SC, Piekos JA, Jasper EA, Aronoff DM, Edwards TL, Velez Edwards DR. Association of genetically-predicted placental gene expression with adult blood pressure traits. Journal of hypertension. 2023 Jun 1;41(41). 1024-1032. NIHMSID: NIHMS1880334.
Abstract
Blood pressure is a complex, polygenic trait, and the need to identify prehypertensive risks and new gene targets for blood pressure control therapies or prevention continues. We hypothesize a developmental origins model of blood pressure traits through the life course where the placenta is a conduit mediating genomic and nongenomic transmission of disease risk. Genetic control of placental gene expression has recently been described through expression quantitative trait loci (eQTL) studies which have identified associations with childhood phenotypes.