A Vanderbilt University Medical Center pilot study of treating late-life depression in nonsmokers with transdermal nicotine (nicotine patch) has yielded some promising results, but the study’s author cautions that more study is needed. Late-life depression — depression that occurs in adults 60 years or older — is characterized by poor response to antidepressant medications and often memory issues. About half of those treated for late-life depression fail to respond to initial treatments.