Jill Simmons Publications

Bone Research:

Articles in Peer-Reviewed Journals:

  1. Simmons J, Chow E, Koehler E, Esbenshade A, Sanders J, Smith LA, Friedman D.  Significant 25-hydroxyvitamin D deficiency in child and adolescent survivors of Acute Lymphoblastic Leukemia:  Treatment with chemotherapy compared with allogeneic stem cell transplant.  Pediatric Blood and Cancer. 56(7), July 2011, 1114-1119. PMID: 21488156 PMCID: PMC3135735

 

  1. Simmons J, Raines M, Ness K, Hall R, Gebretsadik T, Mohan S, Spagnoli A.  Metabolic Control and Bone Health in Adolescents with Type 1 Diabetes.   International Journal of Pediatric Endocrinology. 2011(13), November 2011. PMID: 22029838 PMCID: PMC3215174

 

  1. Whyte M, Greenberg C, Salman N, Bober M, McAlister W, Wenkert D, VanSickle B, Simmons J, Edgar T, Bauer M, Hamdan M, Bishop N, Lutz, R, McGinn M, Craig S, Moore J, Taylor J, Cleveland R, Cranley W, Lim R, Thacher T, Mayhew J, Downs M, Millan J, Skrinar A, Crine P, Landy H. Enzyme Replacement Therapy In Life-Threatening Hypophosphatasia. New England Journal of Medicine. 366 (10), March 2012, 904-913. PMID: 22397652

 

  1. Simmons J, Sheedy C, Lee H, Koh S, Alvarez, J, Koyama T, Friedman D. Prevalence of 25-Hydroxyvitamin D Deficiency in Child and Adolescent Patients Undergoing Hematopoietic Cell Transplantation Compared to a Healthy Population. Pediatric Blood and Cancer. 60 (12), December 2013, 2025-30. PMID: 23868793

 

  1. Esbenshade A, Sopfe J, Zhao Z, Li Z, Campbell C, Simmons J, Friedman D.  Screening for Vitamin D Insufficiency in Pediatric Cancer Survivors. Pediatric Blood and Cancer. 61 (4), April 2014, 723-8. PMID: 24194420

 

  1. Sheedy C, Xu M, Saville B, Simmons J. Vitamin D Abnormalities: More Common in U.S. Children with T1D Than in Healthy Children.  Journal  of Diabetes Mellitus. 4, October 2014, 324-333.

 

Invited Review Articles:

 

  1. Simmons J, Zeitler P.  Osteopenia in Pediatric Patients: When and How to Intervene.  Curr Opin Endocrinol Diabetes. 13, January 2006, 21-25.

 

  1. Simmons J, Zeitler P, and Steelman J.  Advances in the Diagnosis and Treatment of Pediatric Osteoporosis.  Advances in Pediatrics. 54, 2007: 85-114.

 

  1. Simmons J.  Best Practices In: Recognizing and Diagnosis Hypophosphatasia. Clinical Endocrinology News. 8(11), November 2013.

 

Abstracts/ Poster Presentations at Scientific Meetings:

  1. Steelman J, Zeitler P, Simmons J, Schissel D, Giller R, Frangoul H.  Evaluation for Osteoporosis in Pediatric Bone Marrow Transplant Patients. Pediatric Research. 2003;53 (supp4):A858. Presented at the Pediatric Academic Society Annual Meeting (5/03)

 

  1. Raines MD, Spagnoli A, Ness KD, Hall R, Simmons J. Decreased IGF-I Levels Are Associated with Low Bone Mineral Density and Poor Glycemic Control in Adolescents with Type I Diabetes Mellitus. J Clin Endocrinol Metab, 2008, P1-274. Presented at The Endocrine Society’s 90th Annual Meeting (San Francisco, CA 6/08)

 

  1. Simmons J, Chow E, Koehler E, Esbenshade A, Smith LA, Friedman D.  Significant 25-hydroxyvitamin D deficiency in pediatric ALL survivors: treatment with conventional chemotherapy compared with allogeneic hematopoietic stem cell transplant.  Presented at the 11th International Conference on Long-Term Complications of Treatment of Children and Adolescents for Cancer, sponsored by the National Cancer Institute and St. Jude Children’s Research Hospital. (Williamsburg, VA 6/10)
  2. Simmons J, Lee H, Sheedy C, Friedman D. Vitamin D Status, Sun Exposure, and Dietary Intake of Vitamin D in Pediatric Hematopoietic Cell Transplant Patients at Transplant. Presented at the Pediatric Academic Societies National Meeting. (Boston, MA 4/12).

 

  1. Simmons, J,  Greenberg C, Salman N, Bober M, McAlister W, Wenkert D, VanSickle B, Edgar T, Bauer M, Hamdan M, Bishop N, Lutz, R, McGinn M, Craig S, Moore J, Taylor J, Cleveland R, Cranley W, Lim R, Thacher T, Mayhew J, Downs M, Millan J, Skrinar A, Crine P, Landy H, Whyte M.  Improvement in Rickets and Pulmonary Function in Infants with Life-Threatening Hypophosphatasia (HPP) during Bone-Targeted Enzyme Replacement Therapy.  Presented at the Pediatric Academic Societies National Meeting. (Boston, MA 4/12).

 

  1. Whyte M, Bishop N, Simmons J, Lutz R, Vallée M, Melian A, Odrljin T. Asfotase alfa: Sustained efficacy and tolerability in infants and young children with life‐threatening hypophosphatasia.  Presented at the Pediatric Academic Societies National Meeting (Vancouver 5/ 14).
  2. Whyte M, Simmons J, Lutz R, Vallée M, Melian A, Odrljin T, Bishop N. Asfotase alfa: Sustained efficacy and tolerability in infants and young children with life‐threatening hypophosphatasia.  Presented at the European Calcified Tissue Society International Meeting (Prague, CK 5/ 2014)

 

  1. Whyte M, Bishop N, Simmons J, Lutz R, Vallée M, Melian A, Odrljin T. Asfotase alfa: Sustained efficacy and tolerability in infants and young children with life‐threatening hypophosphatasia.  Presented at the Bone Research Society International Meeting (Sheffield, UK 6/ 2014).

 

  1. Dhaliwal R, Foster N, DiMeglio L, Manseau K, Shah V, Kittelsrud J, Simmons J, Mastrandrea L, Styner M, Beck R, Weinstock R. Osteopenia and Osteoporosis in Adult Females with Type 1 Diabetes: Results from the T1D Exchange Registry. Presented at the American Society for Bone and Mineral Research (ASBMR) (Houston, Tx, 9/ 2014)
  2. Simmons J, Bishop N, Lutz R, Zhang H, Fujita K, Whyte M.  Hypophosphatasia:  functional, skeletal and growth Improvements in Infants and Young Children Treated with Asfotase Alfa for 5 Years.  Presented at the American College of Genetics and Metabolism National Meeting (Tampa, FL March 2016)
  3. Garganta M, Jaser S, Lazow M, Hays S, and Simmons J. Cyclic Bisphosphonate Therapy Reduces Bone Pain in Children with Osteogenesis Imperfecta. Presented at the The Endocrine Society National Meeting (Boston, MA April 2016)
  4. Simmons J, Bishop N, Lutz R, Zhang H, Fujita K, Whyte M.  Skeletal, Growth, and Functional Improvements in Infants and Young Children with Life-Threatening Hypophosphatasia Treated with Asfotase Alfa for 5 years.  Accepted for presentation at the American Society for Bone and Mineral Research (Atlanta September 2016)

 

 

National Invited Presentations:

 

April 2012                           “Uncommon Metabolic Bone Diseases in Pediatric Patients: Opportunities

                                             for Improving Diagnosis and Treatment” Satellite Symposium, Pediatric Academic Society National Meeting,  Boston MA

 

March 2015                “Clinical Manifestations of HPP: Genetics and Physiology”, Ancillary Symposium, Endocrine Society National Meeting, San Diego, CA

 

International Invited Presentations:

 

May 2014                     “Clinical Presentation and Pathogenesis of Hypophosphatasia: The Role of Alkaline Phosphatase”. Satellite Symposium, Pediatric Academic Societies and Asian Society for Pediatric Research Meeting , Vancouver, BC 

 

 

October 2015              “The Long-Term Potential for Infants Treated with Asfotase Alpha”  Satellite Symposium, European Society for Pediatric Endocrinology International Meeting, Barcelona, Spain

 

Invited Chair, National:

March 2015                “Avoiding Missteps in the Diagnosis and Management of Hypophosphatasia”  Program Chair, Ancillary Symposium, Endocrine Society National Meeting, San Diego CA

 

April 2016                  “Hypophosphatasia:  New Options in the Management of Alkaline Phosphatase Deficiency” Program Chair, Ancillary Symposium, Endocrine Society National Meeting, Boston MA