Targeting adenoviral vectors for enhanced gene therapy of uterine leiomyomas. | Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC)

Nair S, Curiel DT, Rajaratnam V, Thota C, Al-Hendy A. Targeting adenoviral vectors for enhanced gene therapy of uterine leiomyomas. Human reproduction (Oxford, England). 2013 Sep;28(28). 2398-406. PMID: 23820419 [PubMed] PMCID: PMC3748860

Abstract

Is targeted adenovirus vector, Ad-SSTR-RGD-TK (Adenovirus -human somatostatin receptor subtype 2- arginine, glycine and aspartate-thymidine kinase), given in combination with ganciclovir (GCV) against immortalized human leiomyoma cells (HuLM) a potential therapy for uterine fibroids?