As an attending in the Cardiac Intensive Care Unit, my overarching career goal is to improve early and late outcomes for children with cardiac disease with a primary focus on sedation and pain management practices during the patient’s intensive care unit stay. Through novel data discovery, pattern recognition and visualizations of large amount of data over time, I have developed recommended age-based analgesia/sedation pathways and metrics for patients in the CICU. With current, accurate and timely clinical reports and dashboarding, I continue to lead scientific processes and analytics leveraging data for quality improvement and excellent care at the bedside for the most fragile patients in the pediatric cardiac intensive care unit.
My research on medication choices and the effect on post-operative mechanical ventilation revealed that meticulous post-operatively pain and sedation management allows for less opioid exposure and early liberation from ventilator support after cardiac surgery, even for the youngest patients. My more recent publications include a novel approach to analyze high fidelity hemodynamic data including millions of beat-to-beat systolic blood pressure measurements surrounding recorded medication administration in our PCICU. The development of algorithms around therapies and interventions in the ICU using expert systems allows the analysis of time-series data. This provides insight to clinicians who can be prepared to intervene and act accordingly, improving outcomes for these critically ill children. This work in big data sets has led to my pursuit of board certification in Clinical Informatics and membership with the Alliance of AI in Medicine and Pediatric Centers of Artificial Intelligence in Medicine (PCAIM).
M.D.
Jefferson Medical College, 1996
Residency
Pediatrics - Children's Hospital of Philadelphia
Fellowships
Pediatric Critical Care - Children's Hospital of Philadelphia
Pediatric Cardiac Critical Care - Children's Hospital of Philadelphia
Board Certification
Clinical Informatics, 2023
Ann Holmes works with Dr. Robert Carroll in the Department of Biomedical Informatics at VUMC on interoperability through the NIH such as the INCLUDE Data Coordinating Center. She is passionate about making the future of research more accessible and collaborative.
Chase J. Webber, DO, is Associate Professor of Clinical Medicine in the Division of General Internal Medicine and Public Health within the Department of Medicine at Vanderbilt University Medical Center. As an academic hospitalist and VUSM Master Clinical Teacher, Dr. Webber has a special interest in the education of residents and medical students. He serves as co-director of the "How Doctors Think" Clinical Reasoning course for VUSM medical students. He received the Outstanding Preceptor Inpatient Award in 2020 and the Hugh J. Morgan Teaching Award for Best Faculty Teacher (VA) from the Internal Medicine Housestaff in 2021. His research interests include clinical reasoning, microlearning, and narrative medicine, and he is a member of the Gold Humanism Honors Society. Dr. Webber grew up in Middle Tennessee and is a graduate of Brentwood High School. He completed his BA in English and German literature at Tufts University in Boston, where he was a Tisch College Public Service and Citizenship Scholar. He attended medical school at Kirksville College of Osteopathic Medicine, and then in 2014 returned to New England for his residency in internal medicine at the University of Massachusetts. He joined the Vanderbilt faculty as Assistant Professor of Clinical Medicine in 2017.
Brent Savoie, MD, JD, is an Assistant Professor at Vanderbilt University School of Medicine in the Department of Radiology and is the Section Chief of Cardiothoracic Imaging for Vanderbilt University Medical Center. He is an affiliate faculty member at the Vanderbilt Center for Latin American Studies (CLAS).
Dr. Savoie is a co-founder of Primeros Pasos, a community health program serving communities in Western Guatemala with preventive and curative medical services since 2002. At Primeros Pasos, he participated in the design and implementation of clinical care, health education, and nutrition programs. The clinic serves as a clinical rotation site for Guatemalan and foreign medical students. Vanderbilt medical students have participated in rotations at the clinic since 2004. Prior to working in Guatemala, Dr. Savoie has conducted research and participated in service initiatives in South Africa, Tanzania, and the Dominican Republic.
Brent has published on topics related to health and human rights law – focusing on the impact of intellectual property law on access to pharmaceuticals and medical technology. As part of his research in this area he worked as a legal fellow with Physicians for Human Rights.
Immediately before returning to Vanderbilt, Brent worked at Evolent Health where he partnered with U.S.-based health systems in the design and implementation of initiatives to improve population health outcomes.
Dr. Savoie earned a MD and BA from Vanderbilt University, and also holds a JD with a focus on health and human rights law from the University of Virginia where he was a Jefferson Scholars Foundation Graduate Fellow. He is proficient in Spanish and French.
Peter Rebeiro, PhD, MHS, is an Associate Professor of Medicine in the Division of Infectious Diseases within the Department of Medicine at Vanderbilt University Medical Center. After growing up in Nashville and working at the Comprehensive Care Center during his summer vacations in high school, Peter received his BA in biology from Yale University and worked as a research assistant and coordinator in the epidemiology/outcomes unit of the Center For AIDS Research at Vanderbilt from 2006 through 2010. He received an ScM in Epidemiology (Infectious Diseases), an MHS in Biostatistics and PhD in Epidemiology (General Epidemiology & Methods) from the Johns Hopkins Bloomberg School of Public Health.
Dr. Rebeiro's research focuses on quantifying measurement error, assessing quality of care, and analyzing spatial and contextual factors related to the HIV Continuum of Care and TB treatment outcomes in North, Central, and South America. He is continuing his collaboration with the epidemiology/outcomes group here, and he now also works with the Caribbean, Central and South American Network for HIV Epidemiology (CCASAnet) and the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium, as well as the Regional Prospective Observational Research for TB (RePORT)-Brazil cohort. He also directs the Vanderbilt Epidemiology PhD program.