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Kurnik D, Muszkat M, Li C, Sofowora GG, Solus J, Xie HG, Harris PA, Jiang L, McMunn C, Ihrie P, Dawson EP, Williams SM, Wood AJ, Stein CM. Variations in the alpha2A-adrenergic receptor gene and their functional effects. Clinical pharmacology and therapeutics. 2006 Mar;79(79). 173-85.
Abstract
The alpha2A-adrenergic receptor (ADRA2A) plays a central role in the regulation of systemic sympathetic activity and hence cardiovascular responses such as heart rate and blood pressure. The objectives of this study were to systematically search for variants in the ADRA2A gene, to define the gene's haplotype structure, and to examine potential functional effects of these variants.