Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade.

Understanding resistance to BCL2 inhibition is a critical scientific and clinical challenge. In this issue of , two laboratories use unbiased approaches of large loss-of-function CRISPR/Cas 9 screens to discover targetable liabilities in cell signaling and metabolism to acute myeloid leukemia resistant to BCL2 inhibition...