Kevin Harkins, Ph.D.
Kevin Harkins, PhD, earned his PhD in Biomedical Engineering from the University of Arizona in 2009. He completed a postdoctoral research fellowship at the Vanderbilt University Institute of Imaging Science and joined the faculty in VUMC Radiology in 2021. Dr Harkins’ research is focused on measuring tissue microstructure with magnetic resonance imaging (MRI), and includes diffusion MRI, quantitative MRI, relaxometry, pulse sequence development, and advanced numerical simulation.
PUBLICATIONS:
JS Nyman, T Ketsiri, EA Louie, KD Harkins, MKate Manhard, DF Gochberg, DH Lee, MJ Desai, J Maslow, SB Tanner, MD Does, “Toward the use of MRI measurements of bound and pore water in fracture risk assessment”, Bone 2023; 116863
G Lee, MD Does, R Avila, J Kang, KD Harkins, Y Wu, WE Banks, M Park, D Lu, X Yan, J Uk Kim, S Min Won, AG Evans, JT Joseph, CL Kalmar, AC Pollins, H Karagoz, WP Thayer, Y Huang, JA Rogers, “Implantable, Bioresorbable Radio Frequency Resonant Circuits for Magnetic Resonance Imaging”, Advanced Science 2023; 202301232
BM Hardy, Y Zhu, KD Harkins, B Dhakal, JB Martin, J Xie, J Xu, MD Does, AW Anderson, JC Gore, “Experimental demonstration of diffusion limitations on resolution and SNR in MR microscopy, Journal of Magnetic Resonance 2023; 352, 107479
Z Zu, F Adelnia, KD Harkins, F Wang, J Ostenson, JC Gore, “Correction of errors in estimates of T1ρ at low spin-lock amplitudes in the presence of B0 and B1 inhomogeneities”, NMR in Biomedicine 2023, e4951
F Wang, SY Lee, F Adelnia, K Takahashi, KD Harkins, L He, Z Zu, P Ellinger, M Grundmann, RC Harris, T Takahashi, JC Gore, “Severity of Polycystic Kidney Disease Revealed by Multiparametric MRI”, Magnetic Resonance in Medicine 2023; 90(3), 1151-1165
T Ketsiri, S Uppuganti, KD Harkins, DF Gochberg, JS Nyman, MD Does, “T1 Relaxation of Bound and Pore Water in Cortical Bone”, NMR in Biomedicine 2023; 36(5), e4878
KD Harkins, T Ketsiri, JS Nyman, MD Does, “Fast Bound and Pore Water Mapping of Cortical Bone with Arbitrary Slice Oriented 2D UTE” Magnetic Resonance in Medicine 2023; 89(2), 767-773
F Adelnia, T Davis, LM Acosta, A Puckett, F Wang, Z Zu, KD Harkins, JC Gore, “R1p Dispersion in White Matter Correlates with Cognitive Impairment in Older Adults”, Innovation in Aging 2022; 6(1), 347-347
F Wang, T Otsuka, F Adelnia, K Takahashi, R Delgado, KD Harkins, Z Zu, MP de Caestecker, RC Harris, JC Gore, T Takahashi, “Multiparametric magnetic resonance imaging in diagnosis of long‐term renal atrophy and fibrosis after ischemia reperfusion induced acute kidney injury in mice”, NMR in Biomedicine 2022; 35(10), e4786
D Xie, J Murray, R Lartey, S Gaj, J Kim, M Li, BL Eck, C S Winalski, F Altahawi, MH Jones, NA Obuchowski, LJ Huston, KD Harkins, HT Friel, BM Damon, MV Knopp, CC Kaeding, KP Spindler, X Li, “Multi-vendor Multi-site Quantitative MRI Analysis of Cartilage Degeneration 10 Years after Anterior Cruciate Ligament Reconstruction: MOON-MRI Protocol and Preliminary Results”, Osteoarthritis and Cartilage 2022; 30(12), 1647-1657
T Ketsiri, S Uppuganti, KD Harkins, DF Gochberg, JS. Nyman, MD Does, “Finite Element Analysis of Bone Mechanical Properties using MRI-derived Bound and Pore Water Concentration Maps”, Computer Methods in Biomechanics and Biomedical Engineering 2022
F Adelnia, Z Zu, JT Spear, F Weng, KD Harkins, JC Gore, “Tissue characterization using R1rho dispersion imaging at low locking fields”, Magnetic Resonance Imaging 2021; 84, 1-11
KD Harkins, MD Does, “Efficient gradient waveform measurements with variable-prephasing”, Journal of Mangetic Resonance 2021; 106945
KD Harkins, C Beaulieu, J Xu, JC Gore, MD Does, “A simple estimate of axon size with diffusion MRI”, Neuroimage 2021; 227, 117619
KJ Petersen, M Garza, PMC Donahue, KD Harkins, A Marton, J Titze, J Donahue, R Crescenzi, “Neuroimaging of Cerebral Blood Flow and Sodium in Women with Lipedema”, Obesity 2020; 28(7), 1292-1300
P Tétreault, KD Harkins, CA Baron, R Stobbe, MD Does, C Beaulieu, “Diffusion time dependency along the human corpus callosum and exploration of age and sex differences as assessed by oscillating gradient spin-echo diffusion tensor imaging”, NeuroImage 2020; 210, 116533
MD Does, JL Olesen, KD Harkins, T Serradas-Duarte DF Gochberg, SN Jespersen, N Shemesh, “Evaluation of Principal Component Analysis Image Denoising on Multi-Exponential MRI Relaxometry”, Magnetic Resonance in Medicine 2019; 81(6), 3503-3514
MK Manhard, KD Harkins, DF Gochberg, JS Nyman, MD Does, “30-Second bound and pore water concentration mapping of cortical bone using 2D UTE with optimized half-pulses”, Magnetic Resonance in Medicine 2017; 77 (3), 945-950
KD Harkins, MD Does, “Simulations on the influence of myelin water in diffusion-weighted imaging” Physics in Medicine and Biology 2016; 61(13):4729-4745
J Xu, H Li, K Li, KD Harkins, X Jiang, J Xie, H Kang, RD Dortch, AW Anderson, MD Does, JC Gore, “Fast and simplified mapping of mean axon diameter using temporal diffusion spectroscopy” NMR in Biomedicine 2016; 29 (4), 400-410
KD Harkins, J Xu, AN Dula, K Li, WM Valentine, DF Gochberg, JC Gore, MD Does, “The Microstructural Correlates of T1 in White Matter” Magnetic Resonance in Medicine 2015; 75(3):1341-5;
KD Harkins, RA Horch, MD Does, “Simple and Robust Slice Selection for Ultra-Short Echo Time MRI” Magnetic Resonance in Medicine 2015; 73(6):2204-221
KD Harkins, MD Does, WA Grissom, “Iterative Method for Predistortion of MRI Gradient Waveforms” IEEE Transactions on Medical Imaging 2014; 33(8):1641-1647
J Xu, H Li, KD Harkins, X Jiang, J Xie, H Kang, MD Does, JC Gore, “Mapping mean axon diameter and axonal volume fraction by MRI using temporal diffusion spectroscopy” NeuroImage 2014; 103:10-19
MK Manhard, RA Horch, KD Harkins, DF Gochberg, JS Nyman, MD Does, “Validation of quantitative bound- and pore-water imaging in cortical bone” Magnetic Resonance in Medicine 2014; 71(6):2166-2171
KD Harkins, WM Valentine, DF Gochberg, MD Does, “In-vivo multi-exponential T2, magnetization transfer and quantitative histology in a rat model of intramyelinic edema” NeuroImage: Clinical 2013; 2:810-817
RD Dortch, KD Harkins, MR Juttukonda, JC Gore, MD Does, “Characterizing inter-compartmental water exchange in myelinated tissue using relaxation exchange spectroscopy” Magnetic Resonance in Medicine 2013; 70(5):1450-1459
KD Harkins, AN Dula, MD Does, “The effect of inter-compartmental water exchange on the apparent myelin water fraction in multi-exponential T2 measurements of rat spinal cord” Magnetic Resonance in Medicine 2012; 67(3):793–800
G Russell, KD Harkins, TW Secomb, JP Galons, TP Trouard, “A finite difference method with periodic boundary conditions for simulations of diffusion-weighted magnetic resonance experiments in tissue”, Physics in Medicine and Biology 2012; 57(4): 35-46
KD Harkins, JP Galons, JL Divijak, TP Trouard, "Changes in intracellular water diffusion and energetic metabolism in response to ischemia in perfused C6 rat glioma cells" Magnetic Resonance in Medicine 2011; 66(3):859-867
KD Harkins, JP Galons, TW Secomb, TP Trouard, "Assessment of the Effect of Cellular Tissue Properties on ADC Measurements by Numerical Simulation of Water Diffusion" Magnetic Resonance in Medicine 2009; 62(6):1414-1422
TP Trouard, KD Harkins, JL Divijak, RJ Gillies, J-P Galons, “Ischemia-induced changes of intracellular water diffusion in rat glioma cell cultures” Magnetic Resonance in Medicine 2008; 60(2):258-264