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Key Papers

Highlight studies of the APR in Orthopaedic Surgery and Adverse complication

	Plasminogen activation in the musculoskeletal acute phase response: Injury, repair, and disease - Gibson - 2020 - Research and Practice in Thrombosis and Haemostasis - Wiley Online Library Plasminogen activation in the musculoskeletal acute phase response: Injury, repair, and disease Breanne H.Y. Gibson Matthew T. Duvernay PhD Stephanie N. Moore‐Lotridge PhD Matthew J. Flick PhD Jonathan G. Schoenecker MD, PhD

	Characterizing the Acute Phase Response in Healthy Patients Following Total Joint Arthroplasty: Predictable and Consistent - ScienceDirect Characterizing the Acute Phase Response in Healthy Patients Following Total Joint Arthroplasty: Predictable and Consistent Author links open overlay panelWilliam K.OelsnerBSabStephen M.EngstromMDaMichael A.BenvenutiBScThomas J.AnABcRichard A.JacobsonMDdGregory G.PolkowskiMD, MScaJonathan G.SchoeneckerMD, PhDa
	Elevated d-Dimer Is Not Predictive of Symptomatic Deep Venous Thrombosis After Total Joint Arthroplasty - ScienceDirect Elevated d-Dimer Is Not Predictive of Symptomatic Deep Venous Thrombosis After Total Joint Arthroplasty Author links open overlay panelThomas J.AnABaStephen M.EngstromMDbWilliam K.OelsnerBScMichael A.BenvenutiBSaGregory G.PolkowskiMDbJonathan G.SchoeneckerMD, PhDbdef
	Do Corticosteroids Attenuate the Peri-Operative Acute Phase Response After Total Knee Arthroplasty? - ScienceDirect Do Corticosteroids Attenuate the Peri-Operative Acute Phase Response After Total Knee Arthroplasty? Author links open overlay panelAdam C.BrekkeMDaEmilie J.AmaroMDaSamuel L.PoseyBSbStephen M.EngstromMDaGregory G.PolkowskiMDaJonathan G.SchoeneckerMD, PhDacde
	Albumin and the fibrinogen-to-albumin ratio: Biomarkers for the acute phase response following total knee arthroplasty (plos.org) Albumin and the fibrinogen-to-albumin ratio: Biomarkers for the acute phase response following total knee arthroplasty Emilie Amaro,Stephanie N. Moore-Lotridge,Bronson Wessinger,Michael A. Benvenuti,Thomas J. An,William K. Oelsner,Gregory G. Polkowski,Jonathan G. Schoenecker

Highlight APR and Epidemiologic Studies in Cancer

	Autocrine VEGF/VEGFR1 Signaling in a Subpopulation of Cells Associates with Aggressive Osteosarcoma \| Molecular Cancer Research (aacrjournals.org) Ohba T, Cates JM, Cole HA, Slosky DA, Haro H, Ando T, Schwartz HS, Schoenecker JG Autocrine VEGF/VEGFR1 Signaling in a Subpopulation of Cells Associates with Aggressive Osteosarcoma Mol Cancer Res. 2014 Aug;12(8):1100-11. PMID: 24759089- This was featured on the Cover of Journal
	Bisphosphonates Inhibit Osteosarcoma‐Mediated Osteolysis Via Attenuation of Tumor Expression of MCP‐1 and RANKL - Ohba - 2014 - Journal of Bone and Mineral Research - Wiley Online Library Ohba T, Cole HA, Cates JM, Slosky DA, Haro H, Ando T, Schwartz HS, Schoenecker JG. Bisphosphonates Inhibit Osteosarcoma-Mediated Osteolysis Via Attenuation of Tumor Expression of MCP-1 and RANKL. J Bone Miner Res. 2014 Jan 20. PMID:24443409
	Thrombin induces osteosarcoma growth, a function inhibited by low molecular weight heparin in vitro and in vivo - Ichikawa - 2012 - Cancer - Wiley Online Library Ichikawa J, Cole HA, Magnussen RA, Mignemi NA, Butler M, Holt GE, Cates JM, PhD, Hamm HE, O’Rear L, Yuasa M, Pabla B, Haro H, Schwartz HS, Schoenecker JG. Thrombin Induces Osteosarcoma Growth; A Function Inhibited By Low Molecular Weight Heparin in vitro and in vivo. Cancer. 118(9) 2494-2506,2012. PMID:21953059
	Pleiotropic effects of bisphosphonates on osteosarcoma - ScienceDirect Pleiotropic effects of bisphosphonates on osteosarcoma Author links open overlay panelTetsuroOhbaafJustin M.M.CatescHeather A.ColeaDavid A.SloskygHirotakaHarofJiroIchikawafTakashiAndofHerbert S.SchwartzaJonathan G.Schoeneckerabcde
	Proximal location in extremity long bones is a poor prognostic factor for osteosarcoma: A retrospective cohort study of 153 patients (tandfonline.com) Proximal location in extremity long bones is a poor prognostic factor for osteosarcoma: A retrospective cohort study of 153 patients Justin M. M. Cates &Jonathan G. Schoenecker
	Pediatric Musculoskeletal Infection \| JPOSNA Moore-Lotridge, SN., Gibson, BHY., Duvernay, MT., Martus, JE., Thomsen, IP., Schoenecker, JG. Current Concept Review: Pediatric Musculoskeletal Infection- An Update Through the Four Pillars of Critical Care and Immunothrombotic Similarities with COVID-19. July 2020. JPOSNA. Published online Volume 2.
	The Heterogeneity of Pediatric Knee Infections: A Retrospective Analysis - PubMed (nih.gov) Gibian JT, Daryoush JR, Wollenman CC, Johnson SR, Henry A, Koehler RJ, Moore-Lotridge SN, Schoenecker JG. The Heterogeneity of Pediatric Knee Infections: A Retrospective Analysis. J Pediatr Orthop. 2020 Jul;40(6):314-321. doi: 10.1097/BPO.0000000000001425. PubMed PMID: 32501930
	Necrotizing Fasciitis: Pillaging the Acute Phase Response: JBJS (lww.com) Hysong AA, Posey SL, Blum DM, Benvenuti MA, Benvenuti TA, Johnson SR, An TJ, Devin JK, Obremskey WT, Martus JE, Moore-Lotridge SN, Schoenecker JG. Necrotizing Fasciitis: Pillaging the Acute Phase Response. J Bone Joint Surg Am. 2020 Mar 18;102(6):526-537. doi: 10.2106/JBJS.19.00591. PubMed PMID: 31977818
	C-Reactive Protein Predicts Risk of Venous Thromboembolism in Pediatric Musculoskeletal Infection - PubMed (nih.gov) Amaro E, Marvi TK, Posey SL, Benvenuti MA, An TJ, Dale KM, Lovejoy SA, Martus JE, Johnson ME, Mencio GA, Moore-Lotridge SN, Thomsen IP, Schoenecker JG. C-Reactive Protein Predicts Risk of Venous Thromboembolism in Pediatric Musculoskeletal Infection. J Pediatr Orthop. 2019 Jan;39(1):e62-e67. doi: 10.1097/BPO.0000000000001256. PubMed PMID: 30300275
	A Novel Classification System Based on Dissemination of Musculosk...: Ingenta Connect Mignemi ME, Benvenuti MA, An TJ, Martus JE, Mencio GA, Lovejoy SA, Copley LA, Williams DJ, Thomsen IP, Schoenecker JG A Novel Classification System Based on Dissemination of Musculoskeletal Infection is Predictive of Hospital Outcomes. J Pediatr Orthop. 2016 Jun 13. [Epub ahead of print] PMID: 27299780.
	Double-Edged Sword: Musculoskeletal Infection Provoked Acute Phase Response in Children - PubMed (nih.gov) Double-Edged Sword Musculoskeletal Infection Provoked Acute Phase Response in Children Michael Benvenuti, MD 1 Thomas An, MD 1 Emilie Amaro, BS Jeffrey Martus, MD Megan Mignemi, MD Jonathan G. Schoenecker, MD, PhD Show all authors Show footnotes DOI:https://doi.org/10.1016/j.ocl.2016.12.009
	A Clinical Prediction Algorithm to Stratify Pediatric Musculoskeletal Infection by Severity (nih.gov) A Clinical Prediction Algorithm to Stratify Pediatric Musculoskeletal Infection by Severity Michael A Benvenuti, BS,,1 Thomas J An, BA,,1 Megan E Mignemi, MD,2 Jeffrey E Martus, MD,2 Gregory A Mencio, MD,2 Stephen A Lovejoy, MD,2 Isaac P Thomsen, MD, MSCI,3 Jonathan G Schoenecker, MD, PhD,2,5,6 and Derek J Williams, MD, MPH4
	Musculoskeletal Infection: Hijacking the Acute Phase Response - POSNAcademy Infection: Hijacking the Acute Phase Response - POSNAcademy Pediatric Musculoskeletal Infection Hijacking the Acute-Phase Response An, Thomas J. BA1; Benvenuti, Michael A. BS1; Mignemi, Megan E. MD1; Thomsen, Isaac P. MD1; Schoenecker, Jonathan G. MD, PhD1,a
	Vitamin K-Dependent Coagulopathy in Pediatric Osteomyelitis:... : JBJS Case Connector (lww.com) Vitamin K-Dependent Coagulopathy in Pediatric Osteomyelitis A Case Report Mignemi, Megan E. MD1; Langdon, Neal W. BS2; Schoenecker, Jonathan G. MD, PhD3

Highlight Epidemiologic and Clinical Improvement of MSKI

Pediatric Osteomyelitis - POSNAcademy

	Defining the volume of consultations for musculoskeletal infection encountered by pediatric orthopaedic services in the United States (plos.org) Defining the volume of consultations for musculoskeletal infection encountered by pediatric orthopaedic services in the United States Jonathan G. Schoenecker , The Children’s Orthopaedic Trauma and Infection Consortium for Evidence Based Study (CORTICES) Group
	Epidemiology, Diagnosis, and Treatment of Pericapsular Pyomy... : Journal of Pediatric Orthopaedics (lww.com) Epidemiology, Diagnosis, and Treatment of Pericapsular Pyomyositis of the Hip in Children Mignemi, Megan E. MD; Menge, Travis J. MD; Cole, Heather A. BS; Mencio, Gregory A. MD; Martus, Jeffrey E. MD; Lovejoy, Stephen MD; Stutz, Christopher M. MD; Schoenecker, Jonathan G. MD, PhD
	Effects of Antibiotic Timing on Culture Results and Clinical Outcomes in Pediatric Musculoskeletal Infection - PubMed (nih.gov) Effects of Antibiotic Timing on Culture Results and Clinical Outcomes in Pediatric Musculoskeletal Infection Authors: Benvenuti, Michael A. 1 ; An, Thomas J. 1 ; Mignemi, Megan E. 2 ; Martus, Jeffrey E. 2 ; Thomsen, Isaac P. 3 ; Schoenecker, Jonathan G. 4 ;
	Leclercia adecarboxylata Musculoskeletal Infection in an Immune Competent Pediatric Patient: An Emerging Pathogen? (hindawi.com) Leclercia adecarboxylata Musculoskeletal Infection in an Immune Competent Pediatric Patient: An Emerging Pathogen? W. Jeffrey Grantham,1 Shawn S. Funk,1 and Jonathan G. Schoenecker
	Similar Clinical Severity and Outcomes for Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Pediatric Musculoskeletal Infections \| Open Forum Infectious Diseases \| Oxford Academic (oup.com) Similar Clinical Severity and Outcomes for Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Pediatric Musculoskeletal Infections Thomas J. An, Michael A. Benvenuti, Megan E. Mignemi, Jeffrey Martus, James B. Wood, Isaac P. Thomsen, Jonathan G. Schoenecker

Acute Phase Response: Overview of Coagulation

The Woodchipper of Fibrinolysis

Acute Phase Response: Surgery

Acute Phase Response: Overview of Bacterial Hijacking and Infection

Nature's Stone: How the Body Balances Calcification to Bones While Protecting Soft Tissue