Research and Impact | Vanderbilt Orthopaedic Translational Education & Research (VOTER) Group

Pediatric Elbow Fracture Care

Surgical Technique: Closed Reduction and Percutaneous Pinnin... : Journal of Orthopaedic Trauma (lww.com)

Surgical Technique: Closed Reduction and Percutaneous Pinning of Posterolaterally Displaced Supracondylar Humerus Fractures
Prusick, Vincent W. MDa; Gibian, Joseph T. BSb; Ross, Kirsten E. MDa; Moore-Lotridge, Stephanie N. PhDa; Rees, Andrew B. BSa; Mencio, Gregory A. MDa,c; Stutz, Christopher M. MDd; Schoenecker, Jonathan G. MD, PhDa,e,f,c

Pediatric Variants of the Transolecranon Fracture Dislocation: Recognition and Tension Band Fixation: Report of 3 Cases - ScienceDirect

Pediatric Variants of the Transolecranon Fracture Dislocation: Recognition and Tension Band Fixation: Report of 3 Cases
Author links open overlay panelMatthew A.ButlerMDJeffrey E.MartusMDJonathan G.SchoeneckerMD, PhD

Internal Rotation Stress Testing Improves Radiographic Outcomes of Type 3 Supracondylar Humerus Fractures - PubMed (nih.gov)

Internal Rotation Stress Testing Improves Radiographic Outcomes of Type 3 Supracondylar Humerus Fractures
Jennifer M Bauer 1, Christopher M Stutz 2, Jonathan G Schoenecker 1, Steven A Lovejoy 1, Gregory A Mencio 1, Jeffrey E Martus 1

Basic Science: Fracture Repair

	Bone Fracture Acute Phase Response—A Unifying Theory of Fracture Repair: Clinical and Scientific Implications (nih.gov) Baker CE, Moore-Lotridge SN, Hysong AA, Posey SL, Robinette JP, Blum DM, Benvenuti MA, Cole HA, Egawa S, Okawa A, Saito M, McCarthy JR, Nyman JS, Yuasa M, Schoenecker JG. Bone Fracture Acute Phase Response- A Unifying Theory of Clinical and Scientific Implications. Clinical Reviews in Bone and Mineral Metabolism 2018 Dec. https://doi.org/10.1007/s12018-018-9256-x
	Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification - PubMed (nih.gov) Yuasa M, Mignemi NA, Barnett JV, Cates JM, Obremskey W, Bible J, Nyman JS, Okawa A, Yoshii T, Schwartz HS, Flick M, Degen J, Schoenecker JG. Fibrin is dispensable for fracture healing and fibrinolysis is essential for fracture repair and prevention of heterotopic ossification. J Clin Invest. 2015 Aug 3; 125(8):3117-31. PMID: 26214526 ***This manuscript was featured in Fibrinolysis as a Target to Enhance Fracture Healing, N Engl J Med. 2015 Oct 29;373 - PMID: 26510027 JCI - Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification VUMC study shifts thinking on how bone fractures heal \| VUMC Reporter \| Vanderbilt University Broken Bones Don't Heal Like Doctors Thought They Did; Fibrin's Real Role In Wound Healing (medicaldaily.com) Fibrinolysis as a Target to Enhance Fracture Healing \| NEJM The most popular research stories of 2015 \| VUMC Reporter \| Vanderbilt University
	The temporal and spatial development of vascularity in a healing displaced fracture - PubMed (nih.gov) Yuasa M, Mignemi NA, Barnett JV, Cates JM, Nyman JS, Okawa A, Yoshii A, Schwartz H, Schoenecker JG The Temporal and Spatial Development of Vascularity in a Healing Displaced Fracture. Bone. 2014 Oct;67:208-21. doi: 10.1016/j.bone.2014.07.002. Epub 2014 Jul 10 (Cover of Journal – October 2014) – PMID 25016962 –
	Fracture healing in protease‐activated receptor‐2 deficient mice - O'Neill - 2012 - Journal of Orthopaedic Research - Wiley Online Library O’Neill K, Stutz C, Mignemi N, Cole HA, Murry MR, Nyman JS, Hamm H, Schoenecker JG Fracture Healing in Protease-Activated Receptor -2 Deficient Mice. Journal of Orthopaedic Research 2012 Aug;30(8) PMID:22247070.
	Micro-computed tomography assessment of the progression of fracture healing in mice - ScienceDirect Micro-computed tomography assessment of the progression of fracture healing in mice Author links open overlay panelKevin R.O'NeillaChristopher M.StutzaNicholas A.MignemiabMichael C.BurnsfMatthew R.MurryaJeffry S.NymanacgJonathan G.Schoeneckerabcde

Soft Tissue Repair & Calcification

	Plasmin Prevents Dystrophic Calcification After Muscle Injury - Mignemi - 2017 - Journal of Bone and Mineral Research - Wiley Online Library Mignemi NA, Yuasa M, Baker CE, Moore SN, Ihejirika RC, Oelsner WK, Wallace CS, Yoshii T, Okawa A, Revenko AS, MacLeod AR, Bhattacharjee G, Barnett JV, Schwartz HS, Degen JL, Flick MJ, Cates JM, Schoenecker JG. Plasmin Prevents Dystrophic Calcification After Muscle Injury. J Bone Miner Res. 2017 Feb;32(2):294-308. doi: 10.1002/jbmr.2973. Epub 2016 Dec 5. PubMed PMID: 27530373. From Osteoporosis to Heterotopic Ossification: Plasmin Keeps Hydroxyapatite Where It Should Be - Vanderbilt Discover (vumc.org) Plasmin Prevents Dystrophic Calcification After Muscle Injury - Mignemi - 2017 - Journal of Bone and Mineral Research - Wiley Online Library Plasmin prevents muscle ‘hardening’ after injury: study \| VUMC Reporter \| Vanderbilt University
	Trauma-Induced Nanohydroxyapatite Deposition in Skeletal Muscle is Sufficient to Drive Heterotopic Ossification \| SpringerLink Moore-Lotridge SN, Li Q, Gibson BHY, Martin JT, Hawley GD, Arnold TH, Saito M, Tannouri S, Schwartz HS, Gumina RJ, Cates JMM, Uitto J, Schoenecker JG. Trauma-Induced Nanohydroxyapatite Deposition in Skeletal Muscle is Sufficient to Drive Heterotopic Ossification. Calcif Tissue Int. 2019 Apr;104(4):411-425. doi: 10.1007/s00223-018-0502-5. Epub 2018 Dec 4. PubMed PMID: 30515544; PubMed Central PMCID: PMC6437294. Keeping bone in its place \| VUMC Reporter \| Vanderbilt University
	Severe injury-induced osteoporosis and skeletal muscle mineralization: Are these related complications? - ScienceDirect Moore-Lotridge, SN., Ihejirika, R., Gibson, BHY., Posey, SL., Mignemi, NA., Cole, HA., Hawley, GD., Uppuganti, S., Nyman, JS., Schoenecker, JG. Severe injury-induced Osteoporosis and Skeletal Muscle Mineralization: Are these Related Complications? September 2020. Bone Reports. https://doi.org/10.1016/j.bonr.2020.100743 Calcification after severe injury \| VUMC Reporter \| Vanderbilt University
	Validation of a Radiography-Based Quantification Designed to Longitudinally Monitor Soft Tissue Calcification in Skeletal Muscle (plos.org) Moore SN, Hawley GD, Smith EN, Mignemi NA, Ihejirika RC, Yuasa M, Cates JM, Liu X, Schoenecker JG. Validation of a Radiography-Based Quantification Designed to Longitudinally Monitor Soft Tissue Calcification in Skeletal Muscle. PLoS One. 2016;11(7):e0159624. doi: 10.1371/journal.pone.0159624. eCollection 2016. PubMed PMID: 27438007; PubMed Central PMCID: PMC4954695.
	Bisphosphonates: from softening water to treating PXE (nih.gov) Bisphosphonates: from softening water to treating PXE Stephanie N Moore,1,2 S Bobo Tanner,3 and Jonathan G Schoenecker1
	Novel preclinical murine model of trauma-induced elbow stiffness - PubMed (nih.gov) Moore-Lotridge SN, Oelsner WK, Ihejirika Y, Desai MJ, Gebhart SS, Schoenecker JG. Novel preclinical murine model of trauma-induced elbow stiffness. J Exp Orthop. 2018 Sep 18;5(1):36. doi: 10.1186/s40634-018-0155-3. PubMed PMID: 30229498; PubMed Central PMCID: PMC6143496.
	Autologous chondrocyte grafting promotes bone formation in the posterolateral spine (nih.gov) Autologous chondrocyte grafting promotes bone formation in the posterolateral spine J. Alex Sielatycki, 1 Masanori Saito, 1 , 2 Masato Yuasa, 1 , 2 Stephanie N. Moore‐Lotridge, 1 , 3 Sasidhar Uppuganti, 1 Juan M. Colazo, 4 Alexander A. Hysong, 4 J. Patton Robinette, 4 Atsushi Okawa, 2 Toshitaka Yoshii, 2 Herbert S. Schwartz, 1 Jeffry S. Nyman, 1 , 5 , 6 , 7 and Jonathan G. Schoenecker 1 , 3 , 8 , 9 Autologous Chondrocyte Grafting Promotes Bone Formation in the Posterolateral Spine (vanderbilt.edu) ORS ISFR on Twitter: "#JORSpine: Autologous chondrocyte grafting promotes bone formation in the posterolateral spine https://t.co/c7LgVBaNOo #spine #bone #fracture https://t.co/6Vz2Gsir3K" / Twitter

Skeletal Development

	Differential development of the distal and proximal femoral epiphysis and physis in mice - PubMed (nih.gov) Cole HA, Yuasa M, Hawley G, Cates JM, Nyman JS, Schoenecker JG. Differential Development of the Distal and Proximal Femoral Epiphysis and Physis in Mice. Bone. 2012 Oct 15, PMID:23079139
	Fibrin Accumulation Secondary to Loss of Plasmin-Mediated Fibrinolysis Drives Inflammatory Osteoporosis in Mice (nih.gov) Cole HA, Ohba T, Nyman JS, Haro H, Cates JM, Flick MJ, Degen JL, Schoenecker JG. Fibrin accumulation secondary to loss of plasmin-mediated fibrinolysis drives inflammatory osteoporosis. Arthritis Rheumatol. 2014 Aug;66(8):2222-33. doi: 10.1002/art.38639 PMID – 24664548
	2010 Young Investigator Award winner: Therapeutic aprotinin stimulates osteoblast proliferation but inhibits differentiation and bone matrix mineralization - PubMed (nih.gov) Schoenecker JG, Mignemi N, Stutz C, Liu Q, Edwards J, Lynch C, Holt G, Schwartz H, Mencio G, Hamm H. Therapeutic aprotinin stimulates osteoblast proliferation but inhibits differentiation and bone matrix mineralization. Spine. 35(9):1008-16, 2010 PMID:20407341 2010 young investigator award winner: Therapeutic aprotinin stimulates osteoblast proliferation but inhibits differentiation and bone matrix mineralization — University of Texas Southwestern Medical Center (elsevier.com)

Pediatric Hip Conditions

Leptin Elevation as a Risk Factor for Slipped Capital Femoral Epiphysis Independent of Obesity Status - PubMed (nih.gov)

Halverson S, Martus J, Lovejoy S, Mencio G, Schoenecker JG Leptin Elevation as a Risk Factor for Slipped Capital Femoral Epiphysis Independent of Obesity Status. JBJS. 2017 May 99(10) 865-872. PMID: 28509827

Increased Leptin Level in Slipped Capital Femoral Epiphysis | American Academy of Pediatrics (aappublications.org)

A Deeper Look at SCFE and Obesity - Vanderbilt Discover (vumc.org)

Hypertension As an Independent Risk Factor for Slipped Capital Femoral Epiphysis and Tibia Vara in Obese Children | American Academy of Pediatrics (aappublications.org)

Prevalence of Hypertension in Pediatric Tibia Vara and Slipp... : Journal of Pediatric Orthopaedics (lww.com)

Taussig MD, Powell KP, et al., Schoenecker JG, Prevalence of Hypertension in Pediatric Tibia Vara and Slipped Capital Femoral Epiphysis J Pediatr Orthop. 2015 PMID: 26090984

Highlights from our work on Fracture Repair in the Laboratory:

Osteosarcoma

Micro-Computed Tomography Derived Anisotropy Detects Tumor Provoked Deviations in Bone in an Orthotopic Osteosarcoma Murine Model (plos.org)

Micro-Computed Tomography Derived Anisotropy Detects Tumor Provoked Deviations in Bone in an Orthotopic Osteosarcoma Murine Model
Heather A. Cole ,Tetsuro Ohba ,Jiro Ichikawa,Jeffry S. Nyman,Justin M. M. Cates,Hirotaka Haro,Herbert S. Schwartz,Jonathan G. Schoenecker

Quantifying intra‐osseous growth of osteosarcoma in a murine model with radiographic analysis - Cole - 2011 - Journal of Orthopaedic Research - Wiley Online Library

Quantifying intra‐osseous growth of osteosarcoma in a murine model with radiographic analysis
Heather A. Cole, Jiro Ichikawa, Daniel C. Colvin, Lynda O'Rear, Jonathan G. Schoenecker