CDC Funded Spina Bifida Research Program
Douglass B. Clayton, MD serves as principal investigator for two Spina Bifida research projects funded by grants from the Centers for Disease Control and Prevention: The National Spina Bifida Patient Registry (NSBPR) and the Urologic Management to Preserve Initial Renal Function (UMPIRE). The NSBPR is a nationwide multi-center study to collect data on patient demographics, treatment, and outcomes in order to better understand the associations between medical procedures and health outcomes in patients with spina bifida. UMPIRE is an iterative study that seeks to develop the most effective screening and treatment protocol for spina bifida patients and their long-term kidney health.
Selected Publications
- Diagnostic Test Characteristics of Ultrasound-Based Hydronephrosis for Chronic Kidney Disease in Children and Adolescents With Myelomeningocele: Results From the UMPIRE and NSBPR Cohort Studies. Chu DI, Liu T, Williams T, Mix J, Ahn J, Austin JC, Baum M, Clayton D, Jarosz S, Joseph D, Roth E, Routh J, Tu D, Vasquez E, Wallis MC, Wiener J, Cheng E, Yerkes E, Tanaka S. J Urol. 2024 Dec 9: Epub ahead of print. PMID: 39651652.
- Design and methodological considerations of the National Spina Bifida Patient Registry Urologic and Renal Protocol for the newborn and young child. Routh JC, Cheng EY, Austin JC, Baum MA, Gargollo PC, Grady RW, Herron AR, Kim SS, King SJ, Koh CJ, Paramsothy P, Raman L, Schechter MS, Smith KA, Tanaka ST, Thibadeau JK, Walker WO, Wallis MC, Wiener JS, Joseph DB. J Urol 196(6): 1728-1734, 2016.
- Bowel management and continence in adults with spina bifida: results from the National Spina Bifida Registry 2009-2015. Wiener J, Suson KD, Castillo J, Routh JC, Tanaka S, Liu T, Ward E, Thibadeau J, Joseph D, Registry NSBP. J Pediatr Reabil Med 10(3-4): 335-343, 2017. [PMID: 29125526]
- Bladder management and continence outcomes in adults with spina bifida: results from the National Spina Bifida Registry 2009 to 2015. Wiener JS, Suson KD, Castillo J, Routh JC, Tanaka S, Liu T, Ward E, Thibadeau J, Joseph D; National Spina Bifida Registry. J Urol 200(1): 187-194, 2018. [PMID: 29588216]
