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Connection between ATP8B1 gene and Alzheimer's resilience
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Dr. Tim Hohman recently presented findings from a genome-wide association study (GWAS) that confirmed a link between resilience to Alzheimer's disease (AD) pathology and ATP8B1, a gene also involved with bile processing in the liver. Dr. Hohman's approach harmonized data from four different study cohorts, giving his team an exceptionally large sample size (5,108) to work with.
Vanderbilt Memory & Aging Project Grant Renewal
We are excited to announce that funding for the Vanderbilt Memory & Aging Project (VMAP) has been renewed with an $18.2 million, five-year grant from the National Institute on Aging. The size and scope of this grant is a testament to the quality of the data provided by the original research cohort and the dedication of VMAP's investigators and collaborators.
VMAP has supported numerous training grants for early career scientists. Among the project’s higher profile findings to date:
Impact of Childhood Lifestyle Factors on Alzheimer's Disease Prevention
Tim Hohman (Vanderbilt Memory & Alzheimer's Center), PhD, and Catherine Kaczorowski (The Jackson Labratory), PhD, recently co-wrote an editorial for JAMA Neurology entitled "Modifiable Lifestyle Factors in Alzheimer Disease: An Opportunity to Transform the Therapeutic Landscape Through Transdisciplinary Collaboration." The piece discusses existing evidence for early-life lifestyle factors that may contribute to Alzheimer's disease prevention and encourages collaborative research models in the field