2023
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Tao L, Foster P, Russo C, Cassat JE, Humphries RM. The Brief Case: Invasive Ceftriaxone-Resistant Nontyphoidal Salmonella and Antimicrobial Susceptibility Testing Considerations. Journal of clinical microbiology. 2023 May 23;61(61). e0075022.
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Butrico CE, Klopfenstein N, Green ER, Johnson JR, Peck SH, Ibberson CB, Serezani CH, Cassat JE. Hyperglycemia Increases Severity of Staphylococcus aureus Osteomyelitis and Influences Bacterial Genes Required for Survival in Bone. Infection and immunity. 2023 Apr 18;91(91). e0052922.
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Jacobse J, Brown RE, Li J, Pilat JM, Pham L, Short SP, Peek CT, Rolong A, Washington MK, Martinez-Barricarte R, Byndloss MX, Shelton C, Markle JG, Latour YL, Allaman MM, Cassat JE, Wilson KT, Choksi YA, Williams CS, Lau KS, Flynn CR, Casanova JL, Rings EHHM, Samsom JN, Goettel JA. Interleukin-23 receptor signaling impairs the stability and function of colonic regulatory T cells. Cell reports. 2023 Feb 17;42(42). 112128 p.
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Gehrke AE, Mendoza-Bertelli A, Ledo C, Gonzalez CD, Noto Llana M, Blanco C, Sordelli DO, Putman NE, Cassat JE, Delpino MV, Gómez MI. Neutralization of Staphylococcus aureus Protein A Prevents Exacerbated Osteoclast Activity and Bone Loss during Osteomyelitis. Antimicrobial agents and chemotherapy. 2023 Jan 24;67(67). e0114022.
2022
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Petronglo JR, Putnam NE, Ford CA, Cruz-Victorio V, Curry JM, Butrico CE, Fulbright LE, Johnson JR, Peck SH, Fatah SR, Cassat JE. Context-Dependent Roles for Toll-Like Receptors 2 and 9 in the Pathogenesis of Staphylococcus aureus Osteomyelitis. Infection and immunity. 2022 Nov 17;90(90). e0041722.
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Moriarty TF, Metsemakers WJ, Morgenstern M, Hofstee MI, Vallejo Diaz A, Cassat JE, Wildemann B, Depypere M, Schwarz EM, Richards RG. Fracture-related infection. Nature reviews. Disease primers. 2022 Oct 20;8(8). 67 p.
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Perry WJ, Grunenwald CM, Van de Plas R, Witten JC, Martin DR, Apte SS, Cassat JE, Pettersson GB, Caprioli RM, Skaar EP, Spraggins JM. Visualizing Staphylococcus aureus pathogenic membrane modification within the host infection environment by multimodal imaging mass spectrometry. Cell chemical biology. 2022 Jul 21;29(29). 1209-1217.e4. NIHMSID: NIHMS1812992.
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Good CJ, Neumann EK, Butrico CE, Cassat JE, Caprioli RM, Spraggins JM. High Spatial Resolution MALDI Imaging Mass Spectrometry of Fresh-Frozen Bone. Analytical chemistry. 2022 Feb 22;94(94). 3165-3172. NIHMSID: NIHMS1855021.
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Ford CA, Hurford IM, Fulbright LE, Curry JM, Peek CT, Spoonmore TJ, Cruz Victorio V, Johnson JR, Peck SH, Cassat JE. Loss of alters trabecular bone loss during osteomyelitis in a cell-specific manner. Frontiers in cellular and infection microbiology. 12(12). 985467 p.
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Peek CT, Ford CA, Eichelberger KR, Jacobse J, Torres TP, Maseda D, Latour YL, Piazuelo MB, Johnson JR, Byndloss MX, Wilson KT, Rathmell JC, Goettel JA, Cassat JE. Intestinal Inflammation Promotes MDL-1 Osteoclast Precursor Expansion to Trigger Osteoclastogenesis and Bone Loss. Cellular and molecular gastroenterology and hepatology. 14(14). 731-750.
2021
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Ford CA, Spoonmore TJ, Gupta MK, Duvall CL, Guelcher SA, Cassat JE. Diflunisal-loaded poly(propylene sulfide) nanoparticles decrease S. aureus-mediated bone destruction during osteomyelitis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2021 Dec;39(39). 426-437. NIHMSID: NIHMS1656182.
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Cassat JE, Thomsen I. Staphylococcus aureus infections in children. Current opinion in infectious diseases. 2021 Oct 1;34(34). 510-518. NIHMSID: NIHMS1755025.
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Roper PM, Eichelberger KR, Cox L, O'Connor L, Shao C, Ford CA, Fritz SA, Cassat JE, Veis DJ. Contemporary clinical isolates of from pediatric osteomyelitis patients display unique characteristics in a mouse model of hematogenous osteomyelitis. Infection and immunity. 2021 Jun 7. IAI0018021.
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Veis DJ, Cassat JE. Infectious Osteomyelitis: Marrying Bone Biology and Microbiology to Shed New Light on a Persistent Clinical Challenge. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2021 Apr;36(36). 636-643.
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Klopfenstein N, Cassat JE, Monteith A, Miller A, Drury S, Skaar E, Serezani CH. Murine Models for Staphylococcal Infection. Current protocols. 2021 Mar;1(1). e52. NIHMSID: NIHMS1665816.
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Gimza BD, Cassat JE. Mechanisms of Antibiotic Failure During Osteomyelitis. Frontiers in immunology. 12(12). 638085 p.
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Eichelberger KR, Cassat JE. Metabolic Adaptations During and Co-Infection. Frontiers in immunology. 12(12). 797550 p.
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Ford CA, Cassat JE. Measurement of Osteoblast Cytotoxicity Induced by S. aureus Secreted Toxins. Methods in molecular biology (Clifton, N.J.). 2341(2341). 141-152.
2020
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Spoonmore TJ, Ford CA, Curry JM, Guelcher SA, Cassat JE. Concurrent Local Delivery of Diflunisal Limits Bone Destruction but Fails To Improve Systemic Vancomycin Efficacy during Staphylococcus aureus Osteomyelitis. Antimicrobial agents and chemotherapy. 2020 Dec 23;64(64).
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Urish KL, Cassat JE. Staphylococcus aureus Osteomyelitis: Bone, Bugs, and Surgery. Infection and immunity. 2020 Dec 22;88(88).
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Butrico CE, Cassat JE. Quorum Sensing and Toxin Production in Osteomyelitis: Pathogenesis and Paradox. Toxins. 2020 Dec 12;12(12).
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Potter AD, Butrico CE, Ford CA, Curry JM, Trenary IA, Tummarakota SS, Hendrix AS, Young JD, Cassat JE. Host nutrient milieu drives an essential role for aspartate biosynthesis during invasive infection. Proceedings of the National Academy of Sciences of the United States of America. 2020 Dec 2;117(117). 12394-12401.
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Ford CA, Hurford IM, Cassat JE. Antivirulence Strategies for the Treatment of Infections: A Mini Review. Frontiers in microbiology. 11(11). 632706 p.
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Peek CT, Ibberson CB, Cassat JE. Identification of Virulence Determinants During Host-Pathogen Interaction Using Tn-Seq Technology. Methods in molecular biology (Clifton, N.J.). 2069(2069). 155-175.
2019
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Perry WJ, Spraggins JM, Sheldon JR, Grunenwald CM, Heinrichs DE, Cassat JE, Skaar EP, Caprioli RM. Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host. Proceedings of the National Academy of Sciences of the United States of America. 2019 Dec 29;116(116). 21980-21982.
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Krauss JL, Roper PM, Ballard A, Shih CC, Fitzpatrick JAJ, Cassat JE, Ng PY, Pavlos NJ, Veis DJ. Staphylococcus aureus Infects Osteoclasts and Replicates Intracellularly. MBio. 2019 Dec 15;10(10).
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Ryan DJ, Caprioli RM. Patterson NH, Putnam NE, Wilde AD, Weiss A, Perry WJ, Cassat JE, Skaar EP, Spraggins JM. MicroLESA: Integrating Autofluorescence Microscopy, In Situ Micro-Digestions, and Liquid Extraction Surface Analysis for High Spatial Resolution Targeted Proteomic Studies. Analytical chemistry. 2019 May 31.
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Putnam NE. Fulbright LE, Curry JM, Ford CA, Petronglo JR, Hendrix AS, Cassat JE. MyD88 and IL-1R signaling drive antibacterial immunity and osteoclast-driven bone loss during Staphylococcus aureus osteomyelitis. PLoS pathogens. 2019 Apr. e1007744.
2018
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Brandt SL, Putnam NE, Cassat JE, Serezani CH. Innate Immunity to Staphylococcus aureus: Evolving Paradigms in Soft Tissue and Invasive Infections. Journal of immunology. 2018 Jun 15.
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Buenrostro D, Kwakwa KA, Putnam NE, Merkel AR, Johnson JR, Cassat JE, Sterling JA. Early TGF-β inhibition in mice reduces the incidence of breast cancer induced bone disease in a myeloid dependent manner. Bone. 2018 May 16.
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Cassat JE, Moore JL, Wilson KJ, Stark Z, Prentice BM, Van de Plas R, Perry WJ, Zhang Y, Virostko J, Colvin DC, Rose KL, Judd AM, Reyzer ML, Spraggins JM, Grunenwald CM, Gore JC, Caprioli RM, Skaar EP. Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions. Science translational medicine. 2018 Mar 14.
2017
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Frazier SB, Katz S, Wood JB, Cassat JE. An Unusual Source of Sepsis in Two Previously Healthy Children. Clinical pediatrics. 2017 Oct 1. NIHMSID: NIHMS919235.
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Ford CA, Cassat JE. Advances in the local and targeted delivery of anti-infective agents for management of osteomyelitis. Expert review of anti-infective therapy. 2017 Sep. NIHMSID: NIHMS951566.
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Thomsen IP, Sapparapu G, James DB, Cassat JE, Nagarsheth M, Kose N, Putnam N, Boguslawski KM, Jones LS, Wood JB, Creech CB, Torres VJ, Crowe JE. Monoclonal antibodies against the Staphylococcus aureus bicomponent leukotoxin AB (LukAB) isolated following invasive human infection reveal diverse binding and modes of action. The Journal of infectious diseases. 2017 Feb 10.
2016
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Mendoza Bertelli A, Delpino MV, Lattar S, Giai C, Llana MN, Sanjuan N, Cassat JE, Sordelli D, Gómez MI. Staphylococcus aureus protein A enhances osteoclastogenesis via TNFR1 and EGFR signaling. Biochimica et biophysica acta. 2016 Oct.
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Loughran AJ, Gaddy D, Beenken KE, Meeker DG, Morello R, Zhao H, Byrum SD, Tackett AJ, Cassat JE, Smeltzer MS. Impact of sarA and Phenol-Soluble Modulins on the Pathogenesis of Osteomyelitis in Diverse Clinical Isolates of Staphylococcus aureus. Infection and immunity. 2016 Sep.
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Hendrix AS, Spoonmore TJ, Wilde AD, Putnam NE, Hammer ND, Snyder DJ, Guelcher SA, Skaar EP, Cassat JE. Repurposing the nonsteroidal anti-inflammatory drug diflunisal as an osteoprotective, anti-virulence therapy for Staphylococcus aureus osteomyelitis. Antimicrobial agents and chemotherapy. 2016 Jun 20.
2015
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Wilde AD, Snyder DJ, Putnam NE, Valentino MD, Hammer ND, Lonergan ZR, Hinger SA, Aysanoa EE, Blanchard C, Dunman PM, Wasserman GA, Chen J, Shopsin B, Gilmore MS, Skaar EP, Cassat JE. Bacterial Hypoxic Responses Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection. PLoS pathogens. 2015 Dec. e1005341.
2014
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Hammer ND*, Cassat JE*, Noto MJ, Lojek LJ, Chadha AD, Schmitz JE, Creech CB, Skaar EP. Inter- and Intraspecies Metabolite Exchange Promotes Virulence of Antibiotic-Resistant Staphylococcus aureus. Cell host & microbe. 2014 Oct 8.
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Cassat JE, Lee CY, Smeltzer MS. Investigation of biofilm formation in clinical isolates of Staphylococcus aureus. Methods in molecular biology. 2014 Jul. NIHMSID: NIHMS581485.
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Gillon JE, Cassat JE, Di Pentima MC. Validation of two vancomycin nomograms in patients 10 years of age and older. Journal of clinical pharmacology. 2014 Jan.
2013
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Cassat JE, Skaar EP. Recent advances in experimental models of osteomyelitis. Expert review of anti-infective therapy. 2013 Dec.
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Attia AS*, Cassat JE*, Aranmolate SO, Zimmerman LJ, Boyd KL, Skaar EP. Analysis of the Staphylococcus aureus abscess proteome identifies antimicrobial host proteins and bacterial stress responses at the host-pathogen interface. Pathogens and disease. 2013 Jul 11. NIHMSID: NIHMS515082.
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Hammer ND, Reniere ML, Cassat JE, Zhang Y, Hirsch AO, Indriati Hood M, Skaar EP. Two heme-dependent terminal oxidases power Staphylococcus aureus organ-specific colonization of the vertebrate host. MBio. 2013 Jul.
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Cassat JE, Hammer ND, Campbell JP, Benson MA, Perrien DS, Mrak LN, Smeltzer MS, Torres VJ, Skaar EP. A secreted bacterial protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis. Cell host & microbe. 2013 Jun 12. NIHMSID: NIHMS484604.
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Cassat JE, Skaar EP. Iron in infection and immunity. Cell host & microbe. 2013 May 15. NIHMSID: NIHMS470715.
2012
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Cassat JE, Skaar EP. Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity. Seminars in immunopathology. 2012 Mar. NIHMSID: NIHMS519859.
2008
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Tsang LH, Cassat JE, Shaw LN, Beenken KE, Smeltzer MS. Factors contributing to the biofilm-deficient phenotype of Staphylococcus aureus sarA mutants. PloS one. 2008 Oct. e3361.
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Stenz L, François P, Fischer A, Huyghe A, Tangomo M, Hernandez D, Cassat J, Linder P, Schrenzel J. Impact of oleic acid (cis-9-octadecenoic acid) on bacterial viability and biofilm production in Staphylococcus aureus. FEMS microbiology letters. 2008 Oct.
2007
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Rice KC, Mann EE, Endres JL, Weiss EC, Cassat JE, Smeltzer MS, Bayles KW. The cidA murein hydrolase regulator contributes to DNA release and biofilm development in Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America. 2007 May 8.
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Cassat JE, Smeltzer MS, Lee CY. Investigation of biofilm formation in clinical isolates of Staphylococcus aureus. Methods in molecular biology.
2006
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Cassat J, Dunman PM, Murphy E, Projan SJ, Beenken KE, Palm KJ, Yang SJ, Rice KC, Bayles KW, Smeltzer MS. Transcriptional profiling of a Staphylococcus aureus clinical isolate and its isogenic agr and sarA mutants reveals global differences in comparison to the laboratory strain RN6390. Microbiology. 2006 Oct.
2005
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Cassat JE, Dunman PM, McAleese F, Murphy E, Projan SJ, Smeltzer MS. Comparative genomics of Staphylococcus aureus musculoskeletal isolates. Journal of bacteriology. 2005 Jan.
2002
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Kaiser JR, Cassat JE, Lewno MJ. Should antibiotics be discontinued at 48 hours for negative late-onset sepsis evaluations in the neonatal intensive care unit? Journal of perinatology : official journal of the California Perinatal Association. 2002 Sep.