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Van Kaer L, JOYCE S. The hunt for iNKT cell antigens: alpha-galactosidase-deficient mice to the rescue? Immunity. 33(33). 143-514.
Abstract
The endogenous lipids that control the functions of invariant natural killer T (iNKT) cells remain enigmatic. In this issue of Immunity, Darmoise et al. (2010) report that lysosomal alpha-galactosidase A destroys self-antigens recognized by iNKT cells.
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