PUBLICATIONS

2023

• Danielli S, Ma Z, Pantazi E, Kumar A, Demarco B, Fisher F, V U, Weissenrieder J, Lee R, JOYCE S, Foskett J, Bezbradica J. CALHM6 is an immunological synapse ion channel required for macrophage-natural killer cell communication upon bacterial infection EMBO J. 42(42). in press.
• JOYCE S, Okoye D, Driver P. Die Kämpfe únd schláchten—The Struggles and Battles of Innate-Like Effector T Lymphocytes with Microbes Frontiers in Immunology. 14(14). in press.
• JOYCE S. Cancer Antigens: Sources, Generation & Presentation Methods in Molecular Biology. in press.

2022

• JOYCE S. Life in-between: bridging innate & adaptive immunity Journal of Immunology. 2022 Jul 15;209(209). 193--195. http://www.jimmunol.org/content/209/2/193
• Gu W, Madrid D, JOYCE S, Driver J. A single-cell analysis of thymopoiesis and thymic iNKT cell development in pigs Cell Reports. 2022 Jul 5;40(40). 111050 p. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00844-0?_returnURL=https%3A//linkinghub.elsevier.com/retrieve/pii/S2211124722008440%3Fshowall%3Dtrue
• Carson S, Becker W, Garland M, Pagendarm M, Stone T, Arora K, Wang-Bishop L, Baljon J, Cruz D, JOYCE S, Wilson T. A nanovaccine platform for enhancing cellular immunity via cytosolic co-delivery of antigen and immunostimulatory poly(IC) RNA J Controled Release. 345(345). 354--370.
• Suryadevara N, Kumar A, Ye X, Rogers M, Williams V, Wilson J, Karijolich J, JOYCE S. A molecular signature of lung-resident CD8+ T cells elicited by subunit vaccination Scientific Reports. 12(12). 19101 p. https://www.nature.com/articles/s41598-022-21620-7
• JOYCE S. Cancer Antigens: Sources, Generation & Presentation In: Handbook of Cancer and Immunology. Springer Nature; in press.
• Sharma J, Carson C, Douglas T, Wilson J, JOYCE S. Nano-particulate platforms for vaccine delivery to enhance antigen-specific CD8+ T cell response Methods in Molecular Biology. 2412(2412). 367-398. https://link.springer.com/protocol/10.1007%2F978-1-0716-1892-9_19

2021

• JOYCE SEBASTIAN, Okoye G, Van Kaer L. Natural killer T lymphocytes integrate innate sensory information & relay context to effector immune responses Critical Reviews in Immunology. 2021 Dec;41(41). 55--88. https://www.dl.begellhouse.com/journals/2ff21abf44b19838,256bb987559bc247,4eb326212f45ca2d.html
• Miranda-Katz M, Erickson J, Lan J, Ecker A, Yu Z, JOYCE S, Williams J. Novel HLA-B7-restricted human metapneumovirus epitopes enhance viral clearance in mice and are recognized by human CD8+ T cells Scientific Reports. 2021 Oct;11(11). https://www.nature.com/articles/s41598-021-00023-0
• JOYCE S, Ternette N. Know Thy Immune Self & Non-Self: Proteomics informs on the expanse of self and non-self, and how and where they arise Proteomics. 21(21). 2000143 p.

2020

• Shae D, Baljon J, Wehbe M, Christov P, Becker K, Kumar A, Suryadevara N, Carson C, Palmer C, Knight F, JOYCE S, Wilson J. Co-delivery of peptide neoantigens and stimulator of interferon genes (STING) agonists enhances response to cancer vaccines ACS Nano. 2020 Jul 23;14(14). 9904—9916 . https://pubs.acs.org/doi/10.1021/acsnano.0c02765
• Kumar A, Suryadevara N, Wolf K, Wilson J, DiPaolo R, Brien J, JOYCE S. Heterotypic immunity against vaccinia virus in an HLA-B*07:02 transgenic mousepox infection model Scientific Reports. 2020 Jul;10(10). 13167 p. https://www.nature.com/articles/s41598-020-69897-w
• Van Kaer L, JOYCE S. Survivre et vivre: when NKT cells met a Hippo Journal of Experimental Medicine. 2020 Jun; 217 ( 217 ). e20200343. https://doi.org/10.1084/jem.20200343
• Kumar A, Hill T, Gordy L, Suryadevara N, Wu L, Flyak A, Bezbradica J, Van Kaer L, JOYCE S. Nur77 controls tolerance induction, terminal differentiation, and effector functions in semi-invariant natural killer T cells Proceedings of the National Academy of Sciences USA. 2020 Jun;117(117). 17156-17165. https://www-pnas-org.proxy.library.vanderbilt.edu/content/117/29/17156.long
• Bezbradica S., JOYCE S. NKT cells join the two step for inflammasome-independent IL-1β release Cell Reports. 2020 Apr 7;31(31). 107481-1 -- 107481-2. https://doi.org/10.1016/j.celrep.2020.03.045 File

2019

• Knight FC, Gilchuk P, Kumar A, Becker KW, Sevimli S, Jacobson ME, Suryadevara N, Wang-Bishop L, Boyd KL, Crowe JE, JOYCE S, Wilson JT. Mucosal Immunization with a pH-Responsive Nanoparticle Vaccine Induces Protective CD8 Lung-Resident Memory T Cells. ACS nano. 2019 Sep 25;13(13). 10939—10960. 10.1021/acsnano.9b00326 PMID: 31553872 [PubMed]
• JOYCE S, Spiller W, Van Kaer L. NKT CELLS: What one lipid giveth, another taketh away Nature Immunology. 20 (20 ). 1559—1561. http://dx.doi.org/10.1038/s41590-019-0525-8

2018

• Rogers M, Lamens K, Shafagati N, Johnson M, Oury T, JOYCE S, Williams J. CD4+ regulatory T cells exert differential functions during early and late stages of the immune response to respiratory viruses Journal of Immunology. 2018 Aug 15;201(201). 1253-1266. CD4+ regulatory T cells exert differential functions during early and late stages of the immune response to respiratory viruses PMCID: PMC6089537
• Yang J, Kumar A, Vilgelm A, Chen S, Ayers G, Novitskiy S, JOYCE S, Richmond A. Loss of CXCR4 in myeloid cells enhances antitumor immunity and reduces melanoma growth through NK cell and FASL mechanisms Cancer Immunology Research. 2018 Aug. pii: canimm.0045.2018. Loss of CXCR4 in myeloid cells enhances antitumor immunity and reduces melanoma growth through NK cell and FASL mechanisms
• Qiu F, Becker K, Knight F, Baljon J, Sevimli S, Shae D, Gilchuk P, JOYCE S, Wilson JT. Poly(propylacrylic acid)-peptide nanoplexes as a platform for enhancing the immunogenicity of neoantigen cancer vaccines Biomaterials. 2018 Jul 30;182(182). 82-91. Poly(propylacrylic acid)-peptide nanoplexes as a platform for enhancing the immunogenicity of neoantigen cancer vaccines

2017

• Kumar A, Gordy L, Bezbradica J, Stanic A, Hill T, Boothby M, Van Kaer L, JOYCE S. NF-κB PROTECTS NKT CELLS FROM TUMOR NECROSIS FACTOR RECEPTOR 1-INDUCED DEATH Scientific Reports. 2017 Nov 15;7(7). 15594 p. NF- κ B Protects NKT Cells from Tumor Necrosis Factor Receptor 1-induced Death File
• Galassie A, Goll J, Samir P, Jensen T, Hoek K, Howard L, Allos T, Niu X, Gordy L, Creech B, Hill H, JOYCE S, Link A, Edwards K. Proteomics show antigen presentation processes in human immune cells after AS03-H5N1 vaccination Proteomics. 2017 Jun;17(17). 1600453 p. Proteomics show antigen presentation processesin human immune cells after AS03-H5N1 vaccination
• Kumar A, Bezbradica J, Stanic A, JOYCE S. Characterization and Functional Analysis of Mouse Semi-invariant Natural Killer T Cells Current Protocols in Immunology. 2017 Apr 3. 14.13.01--14.13.55. Characterization and Functional Analysis of Mouse Semi-invariant Natural Killer T Cells
• Kumar A, Suryadevara N, Hill T, Bezbradica J, Van Kaer L, JOYCE S. Natural Killer T Cells: an ecological evolutionary developmental biology perspective Frontiers in Immunology. 8(8). 1858 p. Natural Killer T Cells: An Ecological Evolutionary Developmental Biology Perspective
• Sevimli S, Knight F, Gilchuk P, JOYCE S, Wilson J. Fatty acid-mimetic micelles for dual-delivery of antigens and imidazoquinoline adjuvants ACS Biomaterials Science & Engineering. 3(3). 179—194. Fatty acid-mimetic micelles for dual-delivery of antigens and imidazoquinoline adjuvants File
• Howard L, Hoek K, Goll J, Samir P, Galassie A, Allos T, Niu X, Gordy L, Creech C, Prasad N, Jensen T, Hill H, Levy S, JOYCE S, Link A, Edwards K. Cell-based systems biology analysis of AS03-adjuvanted H5N1 avian influenza vaccine in humans PLoS ONE. 12(12). e0167488. Cell-Based Systems Biology Analysis of Human AS03-Adjuvanted H5N1 Avian Influenza Vaccine Responses File PMID: 28099485 [PubMed]

2016

• Gilchuk I, Gilchuk P, Sapparapu G, Lampley R, Singh V, Kose N, Blum D, Hughes L, Satheshkumar P, Townsend M, Kondas A, Reed Z, Weiner Z, Olson V, Hammarlund E, Raue H, Slifka M, Slaughter J, Graham B, Edwards K, Eisenberg R, Cohen G, JOYCE S, Crowe, Jr. J. Cross-Neutralizing and Protective Antibody Specificities of the Human B Cell Response to Poxvirus Infections Cell. 2016 Oct 21;167(167). 684-694. Cross-Neutralizing and Protective Antibody Specificities of the Human B Cell Response to Poxvirus Infections File
• Hill TM, Bezbradica JS, Van Kaer L, JOYCE S. A21653: CD1d-restricted natural killer T cells Encyclopedia of Life Sciences. A20180(A20180). File
• Gilchuk P, Knight FC, Wilson JT, JOYCE S. Eliciting epitope-specific CD8+ T cell response by immunization with microbial protein antigens formulated with alpha-galactosylceramide: theory, practice, & protocols In: Methods in Molecular Biology: Vaccine Adjuvant — Methods and Protocols. Springer Science & Business Media, LLC; 1494(1494). 321-352. Eliciting Epitope-Specific CD8+ T Cell Response by Immunization with Microbial Protein Antigens Formulated with α-Galactosylcera File
• Hastings AK, Gilchuk P, JOYCE S, Williams JV. HLA-A2-restricted MPV epitopes are functional in mice and recognized by human T cells Vaccine. 34(34). 2663-2670. HLA-A2-restricted MPV epitopes are functional in mice and recognized by human T cells File
• Gilchuk P, Hill T, Guy C, McMaster S, Boyd K, Rabacal W, Lu P, Shyr Y, Kohlmeier J, Sebzda E, Green D, JOYCE S. A distinct lung interstitium-resident memory CD8+ T cell subset confers enhanced protection to lower respiratory tract infection Cell Reports. 16(16). 1800-1809. A distinct lung interstitium-resident memory CD8+ T cell subset confers enhanced protection to lower respiratory tract infection File
• Van Kaer L, Wu L, JOYCE S. Mechanisms and Consequences of Antigen Presentation by CD1 Trends in Immunology. 37(37). 738-754. Mechanisms and Consequences of Antigen Presentation by CD1 File
• Li B, Siuta M, Bright V, Koktysh D, Matlock B, Dumas M, Zhu M, Holt A, Stec D, Deng S, Savage P, JOYCE S, Pham W. Improved proliferation of antigen-specific cytolytic T lymphocytes using a multimodal nanovaccine International Joyrnal of Nanomedicine. 11(11). 6103—6121. Improved proliferation of antigen-specific cytolytic T lymphocytes using a multimodal nanovaccine

2015

• Stengel K, Zhao Y, Klus NJ, Kaiser JE, Gordy LE, JOYCE S, Hebert SW, Summers AR. Histone deacetylase 3 is required for efficient T-cell development Molecualr and Cellular Biology. 35(35). 3854–3865. Histone deacetylase 3 is required for efficient T-cell development File
• Erickson JJ, Lu P, Wen S, Hastiangs AK, Gilchuk P, JOYCE S, Shyr Y, Williams JV. The infected lung rapidly induces a CD8+ T cell exhaustion-like phenotype The Journal of Immunology. 195(195). 4319-4330. Acute Viral Respiratory Infection Rapidly Induces a CD8+ T Cell Exhaustion–like Phenotype File
• Hoek L, Samir P, Niu X, Howard M, Prasad N, Galassie A, Liu Q, Allos M, Guo Y, Shyr Y, Levy S, JOYCE S, Edwards E, Link J. A Cell-based Systems Biology Assessment of Human Blood to Monitor Immune Responses After Influenza Vaccination PLoS ONE. 10(10). e0118528. File
• Spencer CT, Bezbradica JS, Ramos MG, Arico CD, Gilchuk P, Conant SB, Gray JJ, Zheng M, Nu X, Hildebrand W, Link AJ, JOYCE S. Viral infection causes a shift in the self peptide repertoire presented by human MHC class I molecules Proteomics Clinical Applications. 9(9). 1035--1052. Viral infection causes a shift in the self peptide repertoire presented by human MHC class I molecules File
• Gilchuk P, Hill T, Wilson J, JOYCE S. Discovering Protective CD8 T Cell Epitopes—no single immunologic property predicts it! Current Opinion in Immunology. 34(34). 43-51. Discovering Protective CD8 T Cell Epitopes—no single immunologic property predicts it! File
• JOYCE S. Immunoproteasomes edit tumours, which then escapes immune recognition European Journal of Immunology. 45(45). 3241-3245. Immunoproteasomes edit tumours, which then escapes immune recognition File
• Hastings AK, Erickson JJ, Schuster JE, Boyd KL, Tollefson SJ, Johnson M, Gilchuk P, JOYCE S, Williams JV . Role of type I interferon signaling in human metapneumovirus pathogenesis and control of viral replication Journal of Virology. 89(89). 4405-4420. File
• Hill T, Gilchuk P, Cicek B, Osina M, Boyd K, Durrant D, Metzger D, Khanna K, JOYCE S. Border patrol gone awry: lung NKT cell activation by Francisella tularensis exacerbates tularemia-like disease PLoS Pathogens. 11(11). e1004975. Border Patrol Gone Awry: Lung NKT Cell Activation by Francisella tularensis Exacerbates Tularemia-Like Disease File
• Wen S, Schuster J, Gilchuk P, Boyd K, JOYCE S, Williams J. Lung CD8+ T cell impairment occurs during human metapneumovirus infection despite virus-like particle (VLP) induction of functional CD8+ T cells Journal of Virology. 89(89). 8713-8726. File

2014

• Wen SC, Tollefson SJ, Johnson M, Gilchuk P, Boyd KL, Shepherd B, Joyce S, Williams JV. Acute clearance of human metapneumovirus occurs independently of natural killer cells. Journal of virology. 2014 Sep 15;88(88). 10963-9. PMID: 24965465 [PubMed]
• Wen SC, Tollefson SJ, Johnson M, Gilchuk P, Boyd KL, Shepherd B, JOYCE S, Williams J. Acute clearance of human metapneumovirus occurs independently of natural killer cells Journal of Virology. 88(88). 10963-10969. PMID: 24965465 [PubMed]
• Yang J, Hawkins O, Barham W, Gilchuk P, Boothby M, Ayers, G, JOYCE S, Karin M, Yull F, Richmond A. Myeloid IKKβ promotes anti-tumor immunity by modulating CCL11 and the innate immune response Cancer Research. 74(74). 7274-7284.

2013

• Gilchuk P, Spencer CT, Conant SB, Hill T, Gray JJ, Niu X, Zheng M, Erickson JJ, Boyd KL, McAfee KJ, Oseroff C, Hadrup SR, Bennink JR, Hildebrand W, Edwards KM, Crowe JE, Williams JV, Buus S, Sette A, Schumacher TN, Link AJ, JOYCE S. Discovering naturally processed antigenic determinants that confer protective T cell immunity. The Journal of Clinical Investigation. 123(123). 1976-1987. PMID: 23543059 [PubMed] PMCID: PMC3635741
• Spencer CT, Dragovic SM, Conant SB, Gray JJ, Zheng M, Samir P, Niu X, Moutaftsi M, Van Kaer L, Sette A, Link AJ, JOYCE S. Sculpting MHC class II-restricted self and non-self peptidome by the class I Ag-processing machinery and its impact on Th-cell responses. European Journal of Immunology. 43(43). 1162-1172. PMID: 23386199 [PubMed] PMCID: PMC3798073 NIHMSID: NIHMS502300.

2012

• Erickson JJ, Gilchuk P, Hastings AK, Tollefson SJ, Johnson M, Downing MB, Boyd KL, Johnson JE, Kim AS, JOYCE S, Williams JV. Viral acute lower respiratory infections impair CD8+ T cells through PD-1. Journal of Clinical Investigation. 122(122). 2967-2982. PMID: 22797302 [PubMed] PMCID: PMC3408742

2011

• Gordy LE, Bezbradica JS, Flyak AI, Spencer CT, Dunkle A, Sun J, Stanic AK, Boothby MR, He YW, Zhao Z, Van Kaer L, JOYCE S. IL-15 regulates homeostasis and terminal maturation of NKT cells. Journal of Immunology. 187(187). 6335-6345. PMID: 22084435 [PubMed] PMCID: PMC3237743 NIHMSID: NIHMS333842.
• JOYCE S, Girardi E, Zajonc DM. NKT cell ligand recognition logic: molecular basis for a synaptic duet and transmission of inflammatory effectors. Journal of Immunology. 187(187). 1081-1089. PMID: 21772035 [PubMed] PMCID: PMC3166221 NIHMSID: NIHMS296831.
• Dragovic SM, Hill T, Christianson GJ, Kim S, Elliott T, Scott D, Roopenian DC, Van Kaer L, JOYCE S. Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigens. Journal of Immunology. 186(186). 6683-6692. PMID: 21572029 [PubMed] PMCID: PMC3537507 NIHMSID: NIHMS430044.
• Aiken C, JOYCE S. Immunology: TRIM5 does double duty. Nature. 472(472). 305-306. PMID: 21512569 [PubMed]
• Boelte KC, Gordy LE, JOYCE S, Thompson MA, Yang L, Lin PC. Rgs2 mediates pro-angiogenic function of myeloid derived suppressor cells in the tumor microenvironment via upregulation of MCP-1. PloS one. 6(6). e18534. PMID: 21494556 [PubMed] PMCID: PMC3073977

2010

• Van Kaer L, JOYCE S. The hunt for iNKT cell antigens: alpha-galactosidase-deficient mice to the rescue? Immunity. 33(33). 143-514. PMID: 20732635 [PubMed]
• Hoek KL, Gordy LE, Collins PL, Parekh VV, Aune TM, JOYCE S, Thomas JW, Van Kaer L, Sebzda E. Follicular B cell trafficking within the spleen actively restricts humoral immune responses. Immunity. 33(33). 254-265. PMID: 20691614 [PubMed] PMCID: PMC2929658 NIHMSID: NIHMS226567.
• Lee K, Gudapati P, Dragovic S, Spencer C, JOYCE S, Killeen N, Magnuson MA, Boothby M. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity. 32(32). 743-753. PMID: 20620941 [PubMed] PMCID: PMC2911434 NIHMSID: NIHMS213641.
• Spencer CT, Gilchuk P, Dragovic SM, JOYCE S. Minor histocompatibility antigens: presentation principles, recognition logic and the potential for a healing hand. Current Opinion in Organ transplantation. 15(15). 512-525. PMID: 20616723 [PubMed]
• JOYCE S, Gordy LE. Natural killer T cell-a cat o' nine lives! The EMBO journal. 29(29). 1475-1476. PMID: 20442728 [PubMed] PMCID: PMC2876948
• Escande-Beillard N, Washburn L, Zekzer D, Wu ZP, Eitan S, Ivkovic S, Lu Y, Dang H, Middleton B, Bilousova TV, Yoshimura Y, Evans CJ, JOYCE S, Tian J, Kaufman DL. Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented. Journal of Immunology. 184(184). 816-823. PMID: 20018625 [PubMed] PMCID: PMC2997386 NIHMSID: NIHMS177779.

2009

• Florence WC, Xia C, Gordy LE, Chen W, Zhang Y, Scott-Browne J, Kinjo Y, Yu KO, Keshipeddy S, Pellicci DG, Patel O, Kjer-Nielsen L, McCluskey J, Godfrey DI, Rossjohn J, Richardson SK, Porcelli SA, Howell AR, Hayakawa K, Gapin L, Zajonc DM, Wang PG, JOYCE S. Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands. EMBO Journal. 28(28). 3579-3590. PMID: 19816402 [PubMed] PMCID: PMC2782097

2008

• Florence WC, Bhat RK, JOYCE S. CD1d-restricted glycolipid antigens: presentation principles, recognition logic and functional consequences. Expert Reviews in Molecular Medicine. 10(10). e20. PMID: 18601810 [PubMed]
• JOYCE S, Van Kaer L. Lung NKT cell commotion takes your breath away. Nature Medicine. 14(14). 609-610. PMID: 18535574 [PubMed]
• Ni CY, Wu ZH, Florence WC, Parekh VV, Arrate MP, Pierce S, Schweitzer B, Van Kaer L, JOYCE S, Miyamoto S, Ballard DW, Oltz EM. Cutting edge: K63-linked polyubiquitination of NEMO modulates TLR signaling and inflammation in vivo. Journal of Immunology. 180(180). 7107-7111. PMID: 18490708 [PubMed] PMCID: PMC2601684 NIHMSID: NIHMS58993.
• JOYCE S, Van Kaer L. Invariant natural killer T cells trigger adaptive lymphocytes to churn up bile. Cell Host & Microbe. 3(3). 275-277. PMID: 18474352 [PubMed]
• Villarino AV, Artis D, Bezbradica JS, Miller O, Saris CJ, JOYCE S, Hunter CA. IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD. International Immunology. 20(20). 739-752. PMID: 18375937 [PubMed]

2007

• Torres VJ, Stauff DL, Pishchany G, Bezbradica JS, Gordy LE, Iturregui J, Anderson KL, Dunman PM, JOYCE S, Skaar EP. A Staphylococcus aureus regulatory system that responds to host heme and modulates virulence. Cell Host & Microbe. 1(1). 109-119. PMID: 18005689 [PubMed] PMCID: PMC2083280 NIHMSID: NIHMS28913.
• Jing Y, Gravenstein S, Chaganty NR, Chen N, Lyerly KH, JOYCE S, Deng Y. Aging is associated with a rapid decline in frequency, alterations in subset composition, and enhanced Th2 response in CD1d-restricted NKT cells from human peripheral blood. Experimental Gerontology. 42(42). 719-732. PMID: 17368996 [PubMed]

2006

• Bezbradica JS, Stanic AK, JOYCE S. Characterization and functional analysis of mouse invariant natural T (iNKT) cells. Current Protocols in Immunology / edited by John E Coligan et al.. Unit 14.13. PMID: 18432968 [PubMed]
• Bezbradica JS, Gordy LE, Stanic AK, Dragovic S, Hill T, Hawiger J, Unutmaz D, Van Kaer L, JOYCE S. Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny. Immunity. 25(25). 487-497. PMID: 16949316 [PubMed]
• Van Kaer L, JOYCE S. Viral evasion of antigen presentation: not just for peptides anymore. Nature Immunology. 7(7). 795-797. PMID: 16855602 [PubMed]
• Major AS, Singh RR, JOYCE S, Van Kaer L. The role of invariant natural killer T cells in lupus and atherogenesis. Immunologic Research. 34(34). 49-66. PMID: 16720898 [PubMed] PMCID: PMC2291524 NIHMSID: NIHMS42596.
• Major AS, JOYCE S, Van Kaer L. Lipid metabolism, atherogenesis and CD1-restricted antigen presentation. Trends in Molecular Medicine. 12(12). 270-278. PMID: 16651026 [PubMed]
• Yan J, Parekh VV, Mendez-Fernandez Y, Olivares-Villagómez D, Dragovic S, Hill T, Roopenian DC, JOYCE S, Van Kaer L. In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules. The Journal of Experimental Medicine. 203(203). 647-659. PMID: 16505142 [PubMed] PMCID: PMC2118255

2005

• Singh AK, Yang JQ, Parekh VV, Wei J, Wang CR, JOYCE S, Singh RR, Van Kaer L. The natural killer T cell ligand alpha-galactosylceramide prevents or promotes pristane-induced lupus in mice. European Journal of Immunology. 35(35). 1143-1154. PMID: 15761849 [PubMed] PMCID: PMC2291523 NIHMSID: NIHMS42598.
• Parekh VV, Wilson MT, Olivares-Villagómez D, Singh AK, Wu L, Wang CR, JOYCE S, Van Kaer L. Glycolipid antigen induces long-term natural killer T cell anergy in mice. The Journal of Clinical Investigation. 115(115). 2572-2583. PMID: 16138194 [PubMed] PMCID: PMC1193878
• Van Kaer L, JOYCE S. Innate immunity: NKT cells in the spotlight. Current Biology. 15(15). R429-431. PMID: 15936267 [PubMed]
• Bezbradica JS, Stanic AK, Matsuki N, Bour-Jordan H, Bluestone JA, Thomas JW, Unutmaz D, Van Kaer L, JOYCE S. Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo. Journal of Immunology. 174(174). 4696-4705. PMID: 15814694 [PubMed]
• Bezbradica JS, Hill T, Stanic AK, Van Kaer L, JOYCE S. Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny. Proceedings of the National Academy of Sciences of the United States of America. 102(102). 5114-5119. PMID: 15792999 [PubMed] PMCID: PMC555981

2004

• Nakai Y, Iwabuchi K, Fujii S, Ishimori N, Dashtsoodol N, Watano K, Mishima T, Iwabuchi C, Tanaka S, Bezbradica JS, Nakayama T, Taniguchi M, Miyake S, Yamamura T, Kitabatake A, Joyce S, Van Kaer L, Onoé K. Natural killer T cells accelerate atherogenesis in mice. Blood. 2004 Oct 1;104(104). 2051-9. PMID: 15113755 [PubMed]
• Parekh VV, Singh AK, Wilson MT, Olivares-Villagómez D, Bezbradica JS, Inazawa H, Ehara H, Sakai T, Serizawa I, Wu L, Wang CR, Joyce S, Van Kaer L. Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids. Journal of immunology (Baltimore, Md. : 1950). 2004 Sep 15;173(173). 3693-706. PMID: 15356115 [PubMed]
• Saito T, Okumura A, Watanabe H, Asano M, Ishida-Okawara A, Sakagami J, Sudo K, Hatano-Yokoe Y, Bezbradica JS, Joyce S, Abo T, Iwakura Y, Suzuki K, Yamagoe S. Increase in hepatic NKT cells in leukocyte cell-derived chemotaxin 2-deficient mice contributes to severe concanavalin A-induced hepatitis. Journal of immunology (Baltimore, Md. : 1950). 2004 Jul 1;173(173). 579-85. PMID: 15210819 [PubMed]
• Stanic AK, Bezbradica JS, Park JJ, Van Kaer L, Boothby MR, Joyce S. Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B. Journal of immunology (Baltimore, Md. : 1950). 2004 Apr 15;172(172). 4667-71. PMID: 15067039 [PubMed]
• Stanic AK, Bezbradica JS, Park JJ, Matsuki N, Mora AL, Van Kaer L, Boothby MR, Joyce S. NF-kappa B controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). 2004 Feb 15;172(172). 2265-73. PMID: 14764695 [PubMed]
• Park JJ, Kang SJ, De Silva AD, Stanic AK, Casorati G, Hachey DL, Cresswell P, Joyce S. Lipid-protein interactions: biosynthetic assembly of CD1 with lipids in the endoplasmic reticulum is evolutionarily conserved. Proceedings of the National Academy of Sciences of the United States of America. 2004 Jan 27;101(101). 1022-6. PMID: 14722359 [PubMed] PMCID: PMC327144
• Major AS, Wilson MT, McCaleb JL, Ru Su Y, Stanic AK, JOYCE S, Van Kaer L, Fazio S, Linton MF. Quantitative and qualitative differences in proatherogenic NKT cells in apolipoprotein E-deficient mice. Arteriosclerosis, Thrombosis, and Vascular biology. 24(24). 2351-2357. PMID: 15472130 [PubMed]

2003

• Yang JQ, Singh AK, Wilson MT, Satoh M, Stanic AK, Park JJ, Hong S, Gadola SD, Mizutani A, Kakumanu SR, Reeves WH, Cerundolo V, Joyce S, Van Kaer L, Singh RR. Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis. Journal of immunology (Baltimore, Md. : 1950). 2003 Aug 15;171(171). 2142-53. PMID: 12902521 [PubMed]
• Motsinger A, Azimzadeh A, Stanic AK, Johnson RP, Van Kaer L, Joyce S, Unutmaz D. Identification and simian immunodeficiency virus infection of CD1d-restricted macaque natural killer T cells. Journal of virology. 2003 Jul;77(77). 8153-8. PMID: 12829854 [PubMed] PMCID: PMC161937
• Chun T, Page MJ, Gapin L, Matsuda JL, Xu H, Nguyen H, Kang HS, Stanic AK, Joyce S, Koltun WA, Chorney MJ, Kronenberg M, Wang CR. CD1d-expressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cells. The Journal of experimental medicine. 2003 Apr 7;197(197). 907-18. PMID: 12682110 [PubMed] PMCID: PMC2193895
• Yang L, Yamagata N, Yadav R, Brandon S, Courtney RL, Morrow JD, Shyr Y, Boothby M, JOYCE S, Carbone DP, Breyer RM. Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor. The Journal of Clinical Investigation. 111(111). 727-735. PMID: 12618527 [PubMed] PMCID: PMC151895
• Stanic AK, De Silva AD, Park JJ, Sriram V, Ichikawa S, Hirabyashi Y, Hayakawa K, Van Kaer L, Brutkiewicz RR, JOYCE S. Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta-D-glucosylceramide synthase deficiency. Proceedings of the National Academy of Sciences of the United States of America. 100(100). 1849-1854. PMID: 12576547 [PubMed] PMCID: PMC149922
• JOYCE S, Van Kaer L. CD1-restricted antigen presentation: an oily matter. Current Opinion in Immunology. 15(15). 95-104. PMID: 12495740 [PubMed]
• Stanic AK, Shashidharamurthy R, Bezbradica JS, Matsuki N, Yoshimura Y, Miyake S, Choi EY, Schell TD, Van Kaer L, Tevethia SS, Roopenian DC, Yamamura T, JOYCE S. Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T(iNKT) cell receptor [corrected]. Journal of Immunology. 171(171). 4539-4551. PMID: 14568927 [PubMed]
• Wilson MT, Johansson C, Olivares-Villagómez D, Singh AK, Stanic AK, Wang CR, JOYCE S, Wick MJ, Van Kaer L. The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion. Proceedings of the National Academy of Sciences of the United States of America. 100(100). 10913-10918. PMID: 12960397 [PubMed] PMCID: PMC196902
• Mora AL, Corn RA, Stanic AK, Goenka S, Aronica M, Stanley S, Ballard DW, JOYCE S, Boothby M. Antiapoptotic function of NF-kappaB in T lymphocytes is influenced by their differentiation status: roles of Fas, c-FLIP, and Bcl-xL. Cell Death and Differentiation. 10(10). 1032-1044. PMID: 12934078 [PubMed]
• Matsuki N, Stanic AK, Embers ME, Van Kaer L, Morel L, JOYCE S. Genetic dissection of Va14Ja18 natural T cell number and function in autoimmune-prone mice. Journal of Immunology. 170(170). 5429-5437. PMID: 12759418 [PubMed]
• Stanic AK, Park JJ, JOYCE S. Innate self recognition by an invariant, rearranged T-cell receptor and its immune consequences. Immunology. 109(109). 171-184. PMID: 12757612 [PubMed] PMCID: PMC1782955
• Yadav R, Yoshimura Y, Boesteanu A, Christianson GJ, Ajayi WU, Shashidharamurthy R, Stanic AK, Roopenian DC, JOYCE S. The H4b minor histocompatibility antigen is caused by a combination of genetically determined and posttranslational modifications. Journal of Immunology. 170(170). 5133-5142. PMID: 12734360 [PubMed]

2002

• Motsinger A, Haas DW, Stanic AK, Van Kaer L, JOYCE S, Unutmaz D. CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection. The Journal of Experimental Medicine. 195(195). 869-879. PMID: 11927631 [PubMed] PMCID: PMC2193731
• De Silva AD, Park JJ, Matsuki N, Stanic AK, Brutkiewicz RR, Medof ME, JOYCE S. Lipid protein interactions: the assembly of CD1d1 with cellular phospholipids occurs in the endoplasmic reticulum. Journal of Immunology. 168(168). 723-733. PMID: 11777966 [PubMed]

2001

• Serreze DV, Johnson EA, Chapman HD, Graser RT, Marron MP, DiLorenzo TP, Silveira P, Yoshimura Y, Nathenson SG, Joyce S. Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool. Diabetes. 2001 Sep;50(50). 1992-2000. PMID: 11522664 [PubMed]
• Singh AK, Wilson MT, Hong S, Olivares-Villagómez D, Du C, Stanic AK, JOYCE S, Sriram S, Koezuka Y, Van Kaer L. Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. The Journal of Experimental Medicine. 194(194). 1801-1811. PMID: 11748281 [PubMed] PMCID: PMC2193577
• JOYCE S. Immune recognition, response, and regulation: how T lymphocytes do it. Immunologic Research. 23(23). 215-228. PMID: 11444386 [PubMed]
• JOYCE S. CD1d and natural T cells: how their properties jump-start the immune system. Cellular and Molecular Life Sciences. 58(58). 442-469. PMID: 11315191 [PubMed]

2000

• Mylin LM, Schell TD, Roberts D, Epler M, Boesteanu A, Collins EJ, Frelinger JA, Joyce S, Tevethia SS. Quantitation of CD8(+) T-lymphocyte responses to multiple epitopes from simian virus 40 (SV40) large T antigen in C57BL/6 mice immunized with SV40, SV40 T-antigen-transformed cells, or vaccinia virus recombinants expressing full-length T antigen or epitope minigenes. Journal of virology. 2000 Aug;74(74). 6922-34. PMID: 10888631 [PubMed] PMCID: PMC112209
• JOYCE S. Natural T cells: cranking up the immune system by prompt cytokine secretion. Proceedings of the National Academy of Sciences of the United States of America. 97(97). 6933-6935. PMID: 10860950 [PubMed] PMCID: PMC34363

1999

• De Silva AD, Boesteanu A, Song R, Nagy N, Harhaj E, Harding CV, JOYCE S. Thermolabile H-2Kb molecules expressed by transporter associated with antigen processing-deficient RMA-S cells are occupied by low-affinity peptides. Journal of Immunology. 163(163). 4413-4420. PMID: 10510382 [PubMed]

1998

• Boesteanu A, Brehm M, Mylin LM, Christianson GJ, Tevethia SS, Roopenian DC, JOYCE S. A molecular basis for how a single TCR interfaces multiple ligands. Journal of Immunology. 161(161). 4719-4727. PMID: 9794402 [PubMed]
• JOYCE S, Woods AS, Yewdell JW, Bennink JR, De Silva AD, Boesteanu A, Balk SP, Cotter RJ, Brutkiewicz RR. Natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol. Science. 279(279). 1541-1544. PMID: 9488653 [PubMed]
• Goyarts EC, Vegh Z, Kalergis AM, Hörig H, Papadopoulos NJ, Young AC, Thomson CT, Chang HC, JOYCE S, Nathenson SG. Point mutations in the beta chain CDR3 can alter the T cell receptor recognition pattern on an MHC class I/peptide complex over a broad interface area. Molecular Immunology. 35(35). 593-607. PMID: 9823758 [PubMed]

1997

• Boesteanu A, Silva AD, Nakajima H, Leonard WJ, Peschon JJ, JOYCE S. Distinct roles for signals relayed through the common cytokine receptor gamma chain and interleukin 7 receptor alpha chain in natural T cell development. The Journal of Experimental Medicine. 186(186). 331-336. PMID: 9221763 [PubMed] PMCID: PMC2198975
• Mendiratta SK, Martin WD, Hong S, Boesteanu A, JOYCE S, Van Kaer L. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity. 6(6). 469-477. PMID: 9133426 [PubMed]
• JOYCE S. Traffic control of completely assembled MHC class I molecules beyond the endoplasmic reticulum. Journal of Molecular Biology. 266(266). 993-1001. PMID: 9086276 [PubMed]

1996

• JOYCE S, Negishi I, Boesteanu A, DeSilva AD, Sharma P, Chorney MJ, Loh DY, Van Kaer L. Expansion of natural (NK1+) T cells that express alpha beta T cell receptors in transporters associated with antigen presentation-1 null and thymus leukemia antigen positive mice. The Journal of Experimental Medicine. 184(184). 1579-1584. PMID: 8879233 [PubMed] PMCID: PMC2192848
• JOYCE S, Nathenson SG. Alloreactivity, antigen recognition and T-cell selection: three diverse T-cell recognition problems with a common solution. Immunological Reviews. 154(154). 59-103. PMID: 9034864 [PubMed]

1994

• JOYCE S, Kuzushima K, Kepecs G, Angeletti RH, Nathenson SG. Characterization of an incompletely assembled major histocompatibility class I molecule (H-2Kb) associated with unusually long peptides: implications for antigen processing and presentation. Proceedings of the National Academy of Sciences of the United States of America. 91(91). 4145-4149. PMID: 8183884 [PubMed] PMCID: PMC43741
• JOYCE S, Tabaczewski P, Angeletti RH, Nathenson SG, Stroynowski I. A nonpolymorphic major histocompatibility complex class Ib molecule binds a large array of diverse self-peptides. The Journal of Experimental Medicine. 179(179). 579-588. PMID: 8294869 [PubMed] PMCID: PMC2191392
• JOYCE S, Nathenson SG. Methods to study peptides associated with MHC class I molecules. Current opinion in immunology. 6(6). 24-31. PMID: 7513524 [PubMed]

1992

• Shibata K, Imarai M, Van Bleek GM, JOYCE S, Nathenson SG. Vesicular stomatitis virus antigenic octapeptide N52-59 is anchored into the groove of the H-2Kb molecule by the side chains of three amino acids and the main-chain atoms of the amino terminus. Proceedings of the National Academy of Sciences of the United States of America. 89(89). 3135-3139. PMID: 1313583 [PubMed] PMCID: PMC48819
• JOYCE S, Sun R, Nathenson SG. Mapping the orientation of an antigenic peptide bound in the antigen binding groove of H-2Kb using a monoclonal antibody. Biochemical and Biophysical Research Communications. 186(186). 1449-1454. PMID: 1380802 [PubMed]